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26 Oct 14:41

pumpkinpienix: igperish: (x) EVERY TIME I SEE HIM SAYING...













pumpkinpienix:

igperish:

(x)

EVERY TIME I SEE HIM SAYING SOMETHING I LOVE HIM MORE UGH

FUCK YEAH DANIEL RADCLIFFE

26 Oct 14:40

[camperjohn64]

26 Oct 14:38

"My daughter has not seen her biological dad since she was four. She’s 11 now. When she was two he..."

“My daughter has not seen her biological dad since she was four. She’s 11 now. When she was two he contacted me and asked if I would allow him to terminate his parental rights so he could stop paying child support and I agreed.. I wanted to spare her the heartache of a revolving door father and the sacrifice of the financial support was well worth him never being able to disappoint her again. I never lied to her about where he went or who her dad was.. I have always answered her questions in the most age appropriate way possible. When she was four he contacted me and told me he has been diagnosed with cancer and would like to see her. I set aside a day and we met in the park. He had asked for two hours. He stayed 20 minutes and we never heard from him again.. Over the summer we ran into somebody that knows him and they commented on how she looks like his other children. They elaborated that he has settled down and has a family now. My stomach tied itself in knots thinking of how hurtful that must be to my daughter.. I cut the conversation short and we got in the car to leave and that’s when I saw her smiling. She said “mom.. He figured out how to be a dad. That’s such a nice thing. I’m happy for his kids.” And that’s the day an 11 year old taught me all I need to know about forgiveness”

- A comment on this Humans of New York post (via aboutme-g)
26 Oct 14:33

Wet Steel

http://oglaf.com/wetsteel/

15 Oct 20:01

Subway, Line 3

by boulet
10 Oct 19:36

The Sake of Argument

'It's not actually ... it's a DEVICE for EXPLORING a PLAUSIBLE REALITY that's not the one we're in, to gain a broader understanding about it.' 'oh, like a boat!' '...' 'Just for the sake of argument, we should get a boat! You can invite the Devil, too, if you want.'
08 Oct 20:07

Photo



25 Sep 19:25

A Softer World: 1156


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22 Sep 19:51

En Garde

'Touch!' 'Nope, I sighed and stared at you with resignation, so I regained emotional right-of-way.'
21 Sep 17:18

breelandwalker: *HIC-BLORP*



breelandwalker:

*HIC-BLORP*

18 Sep 21:26

Photo



18 Sep 17:55

Inventing Invented Stuff

by communitychannel
Because all the good ideas are already taken. What have you invented that's already been invented? Let me know! Also, don't forget to subscribe for new vids every week and follow me on Facebook,...
Views: 518110
21393 ratings
Time: 03:32 More in Entertainment
15 Sep 18:07

Let me fight for you Khaleesi

by Negative0
13 Sep 17:30

A Softer World: 1152


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13 Sep 17:30

Watches

Old people used to write obnoxious thinkpieces about how people these days always wear watches and are slaves to the clock, but now they've switched to writing thinkpieces about how kids these days don't appreciate the benefits of an old-fashioned watch. My position is: The word 'thinkpiece' sounds like a word made up by someone who didn't know about the word 'brain'.
08 Sep 21:48

H.I. #20: Reverse Finger Trap

by CGP Grey
03 Sep 23:42

A Softer World: 1148


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03 Sep 22:23

Ballooning

Time to dance in front of Mary Jane! If I'm lucky, she'll turn out not to practice pre-copulatory sexual cannibalism!
27 Aug 20:14

Race Car Driver Trolls His Opponent During Race

27 Aug 19:57

Unlocking the Mystery of Limb Regeneration: Genes for Lizard Tail Regrowth Determined

by Arlington Hewes

genes regeneration

For people who’ve lost a limb, advances in materials and 3D printing have produced a slew of new prosthetics that deliver greater mobility, custom fitting, and sleek designs. Yet the ability to completely regrow a lost limb remains daunting, despite the growing research on limb regeneration in reptiles, amphibians, and fish.

Now a team led by researchers at Arizona State University have take a significant step in understanding the process of tail regeneration in green anole lizards.

tail-regeneration

[Image from PLOS ONE]

When lizards lose their tails, at least 326 genes (302 of which are also in humans) are activated over the course of regeneration. These genes are involved in the process of embryonic development, would healing, and hormone response. Additionally, genes triggered in the regeneration of a lizard’s tail are in the ‘Wnt pathway’, which also controls stem cells in organs such as the brain and blood vessels.

“Lizards form a complex regenerating structure with cells growing into tissues at a number of sites along the tail,” said co-author and graduate student Elizabeth Hutchins.

After the tail has fallen off, a scab forms on the wound and cells begin to divide underneath it. Satellite cells (a form of stem cell) regrow muscle tissue as new skin, blood vessels, and cartilage regenerate as well.

After the 60 days of regrowth, the new tail isn’t identical to the original. Instead of a spine, a hollow cartilage tube now makes up the internal structure and the muscle groups are distinctly different.

The results were published recently in PLOS ONE.

While complex, the hope of course is that by unraveling the mechanism of tail regeneration, a method for regenerating human limbs might be revealed.

“Lizards basically share the same toolbox of genes as humans.” stated Professor Kenro Kusumi, who led the study. “[They] are the most closely-related animals to humans that can regenerate entire appendages.” He added, “By following the genetic recipe for regeneration that is found in lizards, and then harnessing those same genes in human cells, it may be possible to regrow new cartilage, muscle or even spinal cord in the future.”

While the reality of human limb regeneration is in the distant future, prosthetics will likely continue to become more advanced and smarter as they become less of a medical device and more of a cybernetic enhancement.

With enough success, the research on limb regeneration might ultimately prove more useful in the generation of new kinds of limbs for people, a future that even sci-fi authors struggle to imagine.

[Image credits: PLOS ONEAnole lizard courtesy of Shutterstock]

27 Aug 19:54

Photo



27 Aug 19:54

A Softer World: 1146


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27 Aug 19:05

Nope, Go Again

uno,reverse card,texting,sexting

Submitted by:

25 Aug 23:20

Lego head business man

by Negative0
24 Aug 04:38

WHOA! Spoilers!

bathrooms restrooms

Submitted by:

Tagged: bathrooms , restrooms
21 Aug 18:33

Everyone Knows That's Pearl Jam

Everyone Knows That's Pearl Jam

Submitted by:

Tagged: Hanson , shirts , nirvana
19 Aug 18:22

22 SECONDS

by boulet

















15 Aug 18:26

A Softer World: 1139


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11 Aug 19:19

Laptop girl stock photo

by Negative0
10 Aug 15:37

The Formula For An Episode Of Murder, She Wrote

by Pentadact

My life has changed in many ways since working for my own company, but perhaps the biggest is that I can now watch Murder, She Wrote over breakfast and/or lunch. This is great, but it’s also ingrained the show’s weirdly specific formula in my brain, and now I feel I must write it down. The following is how about 70% of its episodes go – the exceptions are kind of nuts.

Office, day

NEEDLESSLY DICKISH BUSINESSMAN:
Your company is garbage, Desperate! Once I buy it despite hating it, I will change everything you like about it!

DESPERATE BUSINESSMAN:
Go to hell, Needlessly! The merger’s off!

NEEDLESSLY DICKISH BUSINESSMAN:
Without me your company is nothing (but I still want to acquire it)!

DESPERATE BUSINESSMAN:
That’s for me to tearfully acknowledge later and for you to shut up!

NEEDLESSLY DICKISH BUSINESSMAN:
I’m a jerk in my personal life too! (Leaves)

Office, day

REASONABLE SUBORDINATE:
Dammit Desperate, we need this merger or we’re done for!

DESPERATE BUSINESSMAN:
Shut up, closest friend with my best interests at heart! Besides, soon we won’t need Needlessly Dickish OR his money.

REASONABLE SUBORDINATE:
Dammit Desperate, don’t do anything desperate!

DESPERATE BUSINESSMAN:
I don’t have a CHOICE except the one you just mentioned!!

Car, day

JESSICA:
I’m so glad you invited me to Place Where You Live.

JESSICA’S LOVELY FRIEND:
It’s so lovely to see you Jessica! How is your book tour going?

JESSICA:
Very well, thank you. I am a literary titan known to over 75% of humanity and my work is to everyone’s taste.

JESSICA’S LOVELY FRIEND:
That’s great. I just hope you don’t get wrapped up in the FLASHPOINT OF LOCAL TENSIONS going on while you’re here.

JESSICA:
(Raises quizzical eyebrow)

Apartment, day

HANDSOME YOUNG MAN WHO WORKS FOR SOMEONE BUT IS OTHERWISE NOT REALLY INVOLVED:
I love you PRETTY YOUNG WOMAN WHO IS RELATED TO SOMEONE.

PRETTY YOUNG WOMAN WHO IS RELATED TO SOMEONE BUT OTHERWISE NOT REALLY INVOLVED:
Oh, but it’s no use HANDSOME YOUNG MAN WHO WORKS FOR SOMEONE! In some obtuse way this business merger makes our love impossible!

HANDSOME YOUNG MAN WHO WORKS FOR SOMEONE BUT IS OTHERWISE NOT REALLY INVOLVED:
This is weird but accurate.

Docks, night

SHADY CONTACT:
I got the stuff, where’s the money?

DESPERATE BUSINESSMAN:
I didn’t think this through.

SHADY CONTACT:
Hey, you’d BETTER have my money!

DESPERATE BUSINESSMAN:
I didn’t think this through.

SHADY CONTACT:
You messed with the wrong Shady Contact, Desperate! I will definitely and literally kill you! Not a figure of speech! If you’re murdered soon, it was me! You hear that, witnesses who heard the victim arguing with someone around this time?

Docks, day

POLICE IDIOT stands over DESPERATE BUSINESSMAN’S BODY. JESSICA arrives immediately somehow.

POLICE IDIOT:
Looks like an open-and-shut case, Mrs F. Witnesses heard Shady Contact threatening to kill him, and as a police officer I don’t like to look for further evidence or consider any other possibilities.

JESSICA:
I’m not so sure, Idiot! Can you get me his phone records?

POLICE IDIOT:
OK, for some reason it’s fine for me to share that private data. But I’m telling you Mrs F, this time you’re wrong. I know I have a 0% success rate and you solve all of the 22 murders that happen near you every year, but

Office, day

NEEDLESSLY DICKISH BUSINESSMAN:
With Desperate out of the way, this merger will definitely go through! Yes, I had a motive to kill him alright.

IRRELEVANT CHARACTER WHO LOOKS CONFUSINGLY FAMILIAR:
I reply, but say nothing of substance and never become relevant to the plot, although I look enough like someone who is that you’re no longer completely sure of what’s happening.

Lovely house, day

JESSICA’S LOVELY FRIEND:
What’s that?

JESSICA:
Hm? Oh, just Desperate’s phone records from the night he died. Do you know, he didn’t make a single call to his wife that night? Don’t you think that’s odd?

JESSICA’S LOVELY FRIEND:
I like you but no.

JESSICA:
All the same, I’m going to keep looking through these records.

JESSICA’S LOVELY FRIEND:
Well, this isn’t at all the right context for this phrase, but a rolling stone gathers no moss.

JESSICA:
Moss… that’s it!

JESSICA’S LOVELY FRIEND:
That’s what?

JESSICA:
The missing piece of the puzzle!

JESSICA’S LOVELY FRIEND:
What puzzle?

JESSICA:
The puzzle of who killed Desperate Businessman!

JESSICA’S LOVELY FRIEND:
It’s getting weird that you won’t just tell me what you know.

JESSICA:
I have to get to the police station immediately! (leaves)

JESSICA’S LOVELY FRIEND:
Jessica, for fuck’s sake!

Docks, night

SOMEONE’S WIFE, YOU FORGET WHOSE is rummaging through a bin at the crime scene.

JESSICA:
Looking for this? (She holds up an earring)

SOMEONE’S WIFE, YOU FORGET WHOSE:
Jessica! No, I was just… I thought I heard a dog, in the bin.

JESSICA:
I’m afraid it’s over, Someone’s Wife. You killed Desperate for basically the same mundane, practical reason as one of the male suspects, but you didn’t get much screen time so it still seems like a surprise. I found your earring at the crime scene, and when I give it to the police I’m sure they’ll prove it was yours.

SOMEONE’S WIFE, YOU FORGET WHOSE:
Not if I happen to have a gun on me and draw it now, honestly planning to kill an old lady over some fairly flimsy evidence but for some reason wanting to warn her first!

POLICE IDIOT:
(Emerging from the shadows) Drop it, Someone’s Wife!

SOMEONE’S WIFE, YOU FORGET WHOSE:
Oh for God’s sake. Why do you let her do these things as a weird piece of theatre?

POLICE IDIOT:
Her chain of evidence is always hopelessly weak, so we just have to hope you’ll either kill her or confess.

JESSICA:
It’s true. I have no reason to mention this beyond simple smarm now, but I never found any earring.

SOMEONE’S WIFE, YOU FORGET WHOSE:
Then how?!

JESSICA:
Oh, it was quite simple, really. The moss. When I saw you at the funeral earlier, the camera focused weirdly on a piece of moss on your shoe. I happened to remember that this moss only grows in one place in the world, the crime scene, and it only sticks to murderers.

But I had to wait for someone to mention the word ‘moss’ in a different context before I made this trivial extra step as if it was a moment of serendipitous inspiration, which for some reason is how we want crimes to be solved.

SOMEONE’S WIFE, YOU FORGET WHOSE:
I regret stepping in the murder moss.

Always an elevator for some reason, day

HANDSOME YOUNG MAN WHO WORKS FOR SOMEONE:
Jessica, we wanted you to be the first to know: we’ve set a date!

JESSICA:
Oh, that’s wonderful!

PRETTY YOUNG WOMAN WHO IS RELATED TO SOMEONE:
I hope you’ll come to the ceremony!

JESSICA:
Oh, I wouldn’t miss it for the world. Just so long as you don’t expect ALL of your guests to survive!

(All laugh)

JESSICA:
Hundreds of people have died around me.

(Freeze frame)