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28 Apr 21:40

Protecting group free radical C-H trifluoromethylation of peptides

Naoko Ichiishi

first author paper:)

Chem. Sci., 2018, 9,4168-4175
DOI: 10.1039/C8SC00368H, Edge Article
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Naoko Ichiishi, John P. Caldwell, Melissa Lin, Wendy Zhong, Xiaohong Zhu, Eric Streckfuss, Hai-Young Kim, Craig A. Parish, Shane W. Krska
Two radical-based approaches enable the efficient trifluoromethylation of aromatic sidechains in fully unprotected peptides under mild, biocompatible conditions.
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26 Mar 14:16

[ASAP] Reagent Controlled Stereoselective Synthesis of a-Glucans

by Liming Wang, Herman S. Overkleeft, Gijsbert A. van der Marel, Jeroen D. C. Codée

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.8b00669
21 Mar 13:11

[ASAP] Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs

by Jinxu Gao, Adelphe Mfuh, Yuka Amako and Christina M. Woo

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b11639
21 Mar 13:10

[ASAP] Elucidating the Role of the Boronic Esters in the Suzuki–Miyaura Reaction: Structural, Kinetic, and Computational Investigations

by Andy A. Thomas, Andrew F. Zahrt, Connor P. Delaney and Scott E. Denmark

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Journal of the American Chemical Society
DOI: 10.1021/jacs.8b00400
23 Jan 01:57

No Passport or Ticket: How a Woman Evaded Airport Security and Flew to London

by CHRISTINA CARON
Marilyn Hartman has successfully sneaked onto three flights since 2014 and attempted to breach airport security at least a dozen times.
23 Jan 01:56

Philippines Raises Alert Level as Mayon Volcano Eruption Intensifies

by FELIPE VILLAMOR
The volcano is in a stage of “intense unrest” that could trigger a hazardous eruption at any time.
23 Jan 01:53

Naomi Parker Fraley, the Real Rosie the Riveter, Dies at 96

by MARGALIT FOX
Mrs. Fraley’s connection to Rosie was made public in 2016, ending years of speculation over who was the model for the fictional 1940s war worker.
17 Dec 03:24

Enantiospecific and Iterative Suzuki–Miyaura Cross-Couplings

by Jason P. G. Rygus and Cathleen M. Crudden

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b08326
30 Nov 13:55

Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins

by Samuel I. Mann, Tillmann Heinisch, Thomas R. Ward and A. S. Borovik

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b10452
30 Nov 13:49

Irradiation-Induced Heck Reaction of Unactivated Alkyl Halides at Room Temperature

by Guang-Zu Wang, Rui Shang, Wan-Min Cheng and Yao Fu

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b10009
30 Nov 13:49

Concise Synthesis of (−)-Hodgkinsine, (−)-Calycosidine, (−)-Hodgkinsine B, (−)-Quadrigemine C, and (−)-Psycholeine via Convergent and Directed Modular Assembly of Cyclotryptamines

by Petra Lindovska and Mohammad Movassaghi

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b09929
30 Nov 01:51

Total Syntheses of (−)-Majucin and (−)-Jiadifenoxolane A, Complex Majucin-Type Illicium Sesquiterpenes

by Matthew L. Condakes, Kevin Hung, Stephen J. Harwood and Thomas J. Maimone

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b11493
30 Nov 01:47

Simplifying Assays by Tableting Reagents

by Buddhisha Udugama, Pranav Kadhiresan, Amila Samarakoon and Warren C. W. Chan

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07055
16 Nov 15:24

Transition-Metal-Catalyzed Cross-Couplings through Carbene Migratory Insertion

by Ying Xia, Di Qiu and Jianbo Wang
Naoko Ichiishi

carbenoid chemistry

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Chemical Reviews
DOI: 10.1021/acs.chemrev.7b00382
16 Nov 15:19

Chemoselective One-Pot Synthesis of Functionalized Amino-azaheterocycles Enabled by COware

by Thomas A. Clohessy, Alastair Roberts, Eric S. Manas, Vipulkumar K. Patel, Niall A. Anderson and Allan J. B. Watson
Naoko Ichiishi

interesting use of CO ware:)

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Organic Letters
DOI: 10.1021/acs.orglett.7b03214
19 Oct 17:15

Photoredox-Catalyzed Cross-Coupling of Enamides for the Assembly of β-Difluoroimine Synthons

by Jicheng Wu, Ming Lang and Jian Wang

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Organic Letters
DOI: 10.1021/acs.orglett.7b02809
19 Oct 17:10

Directed γ-C(sp3)–H Alkylation of Carboxylic Acid Derivatives through Visible Light Photoredox Catalysis

by Dian-Feng Chen, John C. K. Chu and Tomislav Rovis

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b09306
19 Oct 17:09

Through-Space Activation Can Override Substituent Effects in Electrophilic Aromatic Substitution

by Liangyu Guan, Maxwell Gargiulo Holl, Cody Ross Pitts, Mark D. Struble, Maxime A. Siegler and Thomas Lectka

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b09792
19 Oct 17:07

Direct mapping of the angle-dependent barrier to reaction for Cl + CHD3 using polarized scattering data

by Huilin Pan

Nature Chemistry. doi:10.1038/nchem.2858

Authors: Huilin Pan, Fengyan Wang, Gábor Czakó & Kopin Liu

Two important properties in an activated chemical reaction are the barrier height and its geometrical dependence. Now, a method has been developed to directly map the angle-dependent barrier to reaction from polarized scattering data for the Cl + CHD3 reaction. The method should be applicable to many other direct reactions with a colinear barrier.

19 Oct 17:05

Synthesis and the Nobel Prize in Chemistry

by Jeffrey I. Seeman

Synthesis and the Nobel Prize in Chemistry

Nature Chemistry, Published online: 22 September 2017; doi:10.1038/nchem.2864

The question often arises as to who may have deserved a Nobel Prize but was not awarded one. Rarely is this discussion extended to who should have received more than one Nobel Prize, but in the field of organic synthesis there are some compelling candidates.

04 Oct 02:34

Photoinhibition of FeFe Hydrogenase

by Matteo Sensi, Carole Baffert, Laura Fradale, Charles Gauquelin, Philippe Soucaille, Isabelle Meynial-Salles, Hervé Bottin, Luca de Gioia, Maurizio Bruschi, Vincent Fourmond, Christophe Léger and Luca Bertini

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ACS Catalysis
DOI: 10.1021/acscatal.7b02252
04 Oct 02:27

Design, Syntheses, and in Vitro Evaluation of New Fluorine-18 Radiolabeled Tau-Labeling Molecular Probes

by Luka Rejc, Lojze Šmid, Vladimir Kepe, Črtomir Podlipnik, Amalija Golobič, Mara Bresjanac, Jorge R. Barrio, Andrej Petrič and Janez Košmrlj

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.7b00764
04 Oct 02:21

Free-Radical-Promoted Site-Selective C–H Silylation of Arenes by Using Hydrosilanes

by Zhengbao Xu, Li Chai and Zhong-Quan Liu

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Organic Letters
DOI: 10.1021/acs.orglett.7b02717
04 Oct 02:11

Late-stage chemoselective functional-group manipulation of bioactive natural products with super-electrophilic silylium ions

by Trandon A. Bender

Nature Chemistry. doi:10.1038/nchem.2863

Authors: Trandon A. Bender, Philippa R. Payne & Michel R. Gagné

Determining the structure­–activity relationships for complex structures can be quite challenging, but it is often the method by which many natural products are optimized for use as drugs. Now, the combination of a fluoroaryl borane catalyst, a phosphine additive and a silane reducing agent enables the late-stage selective modification of complex bioactive natural products in order to provide rapid access to a wide array of structures, and therefore functions.

04 Oct 01:55

Manganese(I)-Catalyzed Direct C–H Allylation of Arenes with Allenes

by Shi-Yong Chen, Qingjiang Li and Honggen Wang

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.7b02220
26 Sep 17:12

Enantiospecific Solvolytic Functionalization of Bromochlorides

by Alexander J. Burckle, Bálint Gál, Frederick J. Seidl, Vasil H. Vasilev and Noah Z. Burns
Naoko Ichiishi

Bromonium ion is my favorite three membered ring:)

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07792
26 Sep 17:11

Visible-Light-Promoted C–S Cross-Coupling via Intermolecular Charge Transfer

by Bin Liu, Chern-Hooi Lim and Garret M. Miyake
Naoko Ichiishi

neat transformation.

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07390
26 Sep 17:11

Total Synthesis of Unsymmetrically Oxidized Nuphar Thioalkaloids via Copper-Catalyzed Thiolane Assembly

by Jacob J. Lacharity, Jeremy Fournier, Ping Lu, Artur K. Mailyan, Aaron T. Herrmann and Armen Zakarian
Naoko Ichiishi

Nice approach

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07685
31 Aug 19:48

Drumroll please ... DowDuPont emerges

by Alexander H. Tullo
The next big task for the massive new firm will be to split into three
31 Aug 18:18

Ketones as directing groups in photocatalytic sp3 C-H fluorination

Naoko Ichiishi

Clever!!

Chem. Sci., 2017, 8,6918-6923
DOI: 10.1039/C7SC02703F, Edge Article
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Desta Doro Bume, Cody Ross Pitts, Fereshte Ghorbani, Stefan Andrew Harry, Joseph N. Capilato, Maxime A. Siegler, Thomas Lectka
Visible light-sensitization allows conformationally rigid ketones to act as "directing groups" for aliphatic fluorination using Selectfluor, catalytic benzil, and LEDs.
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