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24 Oct 16:03

Rhodium-Catalyzed Direct Ortho C–H Arylation Using Ketone as Directing Group with Boron Reagent

by Bing Zhang, Huai-Wei Wang, Yan-Shang Kang, Ping Zhang, Hua-Jin Xu, Yi Lu and Wei-Yin Sun

TOC Graphic

Organic Letters
DOI: 10.1021/acs.orglett.7b02931
05 Sep 01:08

Rhodium-Catalyzed Regioselective C7-Functionalization of Indole Derivatives with Acrylates by Using an N-Imino Directing Group

by Xu, Lanting

DOI: 10.1055/s-0036-1588530

An efficient rhodium-catalyzed method for C–H olefination at the C7 position of indoles has been developed. The N-imino directing group was shown to be crucial for high regioselectivity and reactivity of the metal catalyst. The utility of this protocol was further demonstrated through a concise, four-step synthesis of pyroquilon from indole.

© Georg Thieme Verlag Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

28 Jul 13:35

Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects

by Kevin Wu


Nature Chemistry 9, 779 (2017). doi:10.1038/nchem.2741

Authors: Kevin Wu & Abigail G. Doyle

Ligand development underlies many advances in Pd-catalysed cross coupling but has seen limited application in the growing field of Ni catalysis. Now, a phosphine framework is shown to enable Ni-catalysed Suzuki coupling of acetals. Parameterization studies provide structural insight into ligand success and a quantitative model to facilitate further ligand design.

02 Nov 09:16

Enantioselective Synthesis of α-Allyl-α-aryldihydrocoumarins and 3-Isochromanones via Pd-Catalyzed Decarboxylative Asymmetric Allylic Alkylation

by Ramulu Akula and Patrick J. Guiry

TOC Graphic

Organic Letters
DOI: 10.1021/acs.orglett.6b02584