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23 Jan 12:24

Iron-Mediated Azidomethylation or Azidotrideuteromethylation of Active Alkenes with Azidotrimethylsilane and Dimethyl Sulfoxide

by Rui Zhang, Haifei Yu, Zejiang Li, Qinqin Yan, Pan Li, Jilai Wu, Jing Qi, Menglu Jiang, Lixian Sun

Abstract

A radical azidomethylation of various alkenes with azidotrimethylsilane and dimethyl sulfoxide has been achieved under mild reaction conditions, and the method efficiently introduces common and valuable azide and methyl groups into organic compounds. It offers a convenient method for preparing organic azides, which can be easily transformed into related amine derivatives and N-heterocycles. Control experiments such as capturing of the intermediate and gram-scale reactions of the developed system as well as further transformations of the products of the reaction are presented. And a free radical is involved in the reaction process.

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06 Dec 14:42

Highly Substituted Cyclohexenes via Phosphine-Catalyzed [4+2] Annulation of Electron-deficient Dienes and Vinyl Ketones

by Junliang Zhang, Peng Chen, Junyou Zhang

Abstract

A highly efficient phosphine-catalyzed [4+2] annulation of electron-deficient diene and alkyl vinyl ketone was developed for the first time, which provides an easy access to functionalized cyclohexenes. This method has the advantages of mild reaction conditions, widely functional group tolerance, high yields and transition metal free.

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04 Oct 07:49

Visible-Light-Mediated Aerobic Oxidation of N-Alkylpyridinium Salts under Organic Photocatalysis

by Yunhe Jin, Lunyu Ou, Haijun Yang and Hua Fu

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07883
16 Sep 13:20

Ruthenium-Catalyzed ortho/meta-Selective Dual C–H Bonds Functionalizations of Arenes

by Gang Li, Biao Zhu, Xingxing Ma, Chunqi Jia, Xulu Lv, Junjie Wang, Feng Zhao, Yunhe Lv and Suling Yang

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Organic Letters
DOI: 10.1021/acs.orglett.7b02439
28 Jul 12:45

Cu-Catalyzed Hydrocarbonylative C–C Coupling of Terminal Alkynes with Alkyl Iodides

by Li-Jie Cheng and Neal P. Mankad

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Journal of the American Chemical Society
DOI: 10.1021/jacs.7b05205
07 May 02:44

Fe(II)/Au(I) Relay Catalyzed Propargylisoxazole to Pyridine Isomerization: Access to 6-Halonicotinates

by Alexey V. Galenko, Firuza M. Shakirova, Ekaterina E. Galenko, Mikhail S. Novikov and Alexander F. Khlebnikov

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.7b00736
24 Jan 02:34

Chemo- and Regioselective Distal Heteroaryl ipso-Migration: A General Protocol for Heteroarylation of Unactivated Alkenes

by Zhen Wu, Dongping Wang, Yuan Liu, Leitao Huan and Chen Zhu

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Journal of the American Chemical Society
DOI: 10.1021/jacs.6b11234
02 Mar 14:26

C-H functionalization of terminal alkynes towards stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones

Chem. Commun., 2015, 51,5013-5016
DOI: 10.1039/C4CC10438B, Communication
Shekaraiah Devari, Arvind Kumar, Ramesh Deshidi, Bhahwal Ali Shah
An efficient metal free self-sorting tandem protocol for stereospecific synthesis of (E) or (Z) 2-methylthio-1,4-ene-diones has been developed.
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