31 Jan 17:25
by Yao Zhou, Zhonghe Tang, Qiuling Song
A direct and single-step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid-promoted [3+3] annulation between 3-ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope.
18 Jan 09:35
by Artem’ev, Alexander V.
The original four-component reaction between secondary phosphines, primary amines, aldehydes, and elemental sulfur or selenium occurs chemoselectively under mild conditions (60 °C, benzene, 3–9 h) to afford the hitherto unknown functionalized α-aminophosphine sulfides and selenides in good to excellent yields.
© Georg Thieme Verlag Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
09 Dec 16:13
by Nicholas D. Measom, Kenneth D. Down, David J. Hirst, Craig Jamieson, Eric S. Manas, Vipulkumar K. Patel and Don O. Somers
ACS Medicinal Chemistry Letters