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31 Jan 17:25

Lewis Acid-Mediated [3+3] Annulation for the Construction of Substituted Pyrimidine and Pyridine Derivatives

by Yao Zhou, Zhonghe Tang, Qiuling Song


A direct and single-step procedure towards substituted pyrimidine and pyridine derivatives via Lewis acid-promoted [3+3] annulation between 3-ethoxycyclobutanones and enamines or amidines is presented. Diverse substituted pyrimidine and pyridine derivatives were obtained in good to high yields with a wide substrate scope.

Thumbnail image of graphical abstract
18 Jan 09:35

Four-Component Reaction between Secondary Phosphines, Primary Amines, Aldehydes, and Chalcogens: A Facile Access to Functionalized α-Aminophosphine Chalcogenides

by Artem’ev, Alexander V.

DOI: 10.1055/s-0036-1588127

The original four-component reaction between secondary phosphines, primary amines, aldehydes, and elemental sulfur or selenium occurs chemoselectively under mild conditions (60 °C, benzene, 3–9 h) to afford the hitherto unknown functionalized α-aminophosphine sulfides and selenides in good to excellent yields.

© Georg Thieme Verlag Stuttgart · New York

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

17 Jan 09:43

Organocatalytic activation of isocyanides: N-heterocyclic carbene-catalyzed enaminone synthesis from ketones

Chem. Sci., 2017, 8,2401-2406
DOI: 10.1039/C6SC05266E, Edge Article
Open Access Open Access
Jungwon Kim, Soon Hyeok Hong
The first NHC-catalyzed C-C bond formation reaction between ketones and isocyanides was achieved via activation of the isocyanide into an imidoyl intermediate.
The content of this RSS Feed (c) The Royal Society of Chemistry
09 Dec 16:13

Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor

by Nicholas D. Measom, Kenneth D. Down, David J. Hirst, Craig Jamieson, Eric S. Manas, Vipulkumar K. Patel and Don O. Somers

TOC Graphic

ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.6b00281
10 May 14:56

Silicone Brushes: Omniphobic Surfaces with Low Sliding Angles

Silicone Brushes: Omniphobic Surfaces with Low Sliding Angles

Losing contact: Omniphobic surfaces can be readily produced by acid-catalyzed graft polycondensation of dimethyldimethoxysilane (PDMS). Droplets show a very small contact angle hysteresis as well as a low sliding angle of only a few degrees. The nm-thick PDMS layer is neither easily washed away nor depleted. This method offers a novel approach towards the preparation of super-liquid-repelling surfaces.

Sanghyuk Wooh, Doris Vollmer
Angew. Chem. Int. Ed., May 09, 2016, DOI: 10.1002/anie.201511895. Read article