biologists will be like this is a very simplified diagram of a mammalian cell
chemists will be like this is a molecule
okay but this is what the best render of a human cell looks like
They are not kidding
We are full of so many fuckign guys
This is actually a full on interactive map! You can put your cursor over any structure to focus on it and see its name, you can focus on all the structures that are part of a specific pathway and, when you click on proteins, you open it up on PhosphoSitePlus, which is a curated database of proteins and their post-translational modifications. It has a helpful description and summary for each protein!
This is a HUGE complementary resource for learning molecular biology! It really helps to make sense of each individual pathway and it puts everything into perspective. It only focuses on human, rat and certain other animal cells, so it won’t have all the pathways one would wish to see… But for the pathways it does include, consider opening the image and accompanying it as you learn or revise them!
oh wow, thank you for the additional information, i had no idea, that’s so much cooler than just the flat picture.
my family is fucking addicted to macgyvering and it’s becoming a problem. every time something in this house breaks, instead of doing the sensible thing of replacing it or calling someone qualified to fix it, we all group around the offending object with a manic look in our eyes and everyone gets a try at fixing it while being cheered on or ridiculed by the rest.
it’s a beautiful bonding activity, but the “creative” fixes have turned our house into a quasihaunted escape room like contraption where everything works, but only in the wonkiest of ways. you need a huge block of iron to turn on the stove. the oven only works if a specific clock is plugged in. the bread machine has a huge wood block just stapled to it that has become foundational to its function. sometimes when you use the toaster the doorbell rings. and that’s just the kitchen.
it’s all fun and games until you have guests over and you have to lay out the rules of the house like it’s a fucking board game. welcome to the beautiful guest room. don’t pull out the couch yourself you need a screwdriver for that, and that metal rod makes the lamp work so don’t move it. it also made me a terrifying roommate in college, because it makes me think i can fix anything with enough hubris and a drill. you want to call the landlord about a leaky faucet? as if. one time my dad made me install a new power socket because we ran our of extension cords
to the people saying this isn’t safe in the tags: my dad has a engineering degree and my brother is a mechanic this is like. state sanctioned macgyvering. safe sane and consensual macgyvering. our house will not burn down. in fact, i think it has made us all better in approaching problems from all angles when they arise, which has served me well in life, especially in high stress situations.
does our hot water switch off every thirty seconds making showers an exiting exercise in counting and resilience? yes. but one time the door of the train toilet broke, trapping me inside, and i went “well i can either succumb to the panic of claustrophobia or do this family-style” and then spent twenty minutes breaking down the lock with my shoelace and the belt i was wearing. so i’ll take the cold water any day
Never have I wanted to see inside a stranger’s home more
Hana-Rawhiti Kareariki Maipi-Clarke, the youngest MP in Aotearoa, starts a haka to protest the first vote on a bill reinterpreting the 1840 Treaty of Waitangi
From here. If you think arachnids with long legs are just scary please watch this solifugid dig her nest (or try to) like SUCH a goofy little person creature. Look how she shoves dirt with her mouth and then gives it a little pat. Is she even making any progress?!
In addition to gas lighting, there should be something called moon shining, I don’t know what it would be for.
Moon shining, when you convince yourself an option is worth trying despite the many obvious potential drawbacks.
Also horse girl should be a descriptor for a type of anxiety not an affinity. Horse moments when you’re suddenly on high alert for threats everywhere and everything looks like a danger.
There should be a horse girl wizard who exclusively knows protection spells.
Horse girl wizard with hyper vigilance and her the cat girl who follows her around and falls asleep leaning on her and generally makes a nuisance of herself
Horse girl: “We need to GO now, everyone is STARING and they are mad at us.”
Cat girl: Asleep on her shoulder in the restaurant booth seat, drooling, snoring loudly.
Cat girl having a mad cat moment: !!!!!
Horse girl: What?
Cat girl, running: !!!!!!!
Horse girl, chasing: What!! What’s wrong???
Cat girl running in circles: AHHH! WAUGH!
Horse girl: AAAUGH! AARRRGHHHH!
Both running in around in a circle: YAHH! AHHH! YARRRGHH! AHHH!!!
They are alone in a wide open field running around a solitary, small tree.
Horse girl,casts a magic fortress spell, puts a forcefield around it, puts a wall of magical trees around it, casts invisibility, creates a thousand magical traps, and a second forcefield: Whew, finally safe.
Cat girl, sad face.
Horse girl: What.
Cat girl, scratching at the fortress door, looking over her shoulder with a sad face.
Horse girl: NO.
Horse girl: How… how did you do that?
Cat girl: He was a punk! He wasn’t shit!
Horse girl: He- he was a dragon, a huge-
Cat girl, holding up her arms, making finger claws: You gotta make yourself look big! Rarr!
Horse girl: Look b… He was a hunded foot long dragon!
Cat girl: Then I gave it to him. Pow! Right in the snoot!
Horse girl: You… you made a dragon run away by stabbing his nose.
Cat girl: No way! I just popped him one, boom, closed fist! Punk!
Horse girl, shaking: That was an ancient monster of incomprehensible arcane power.
Cat girl: Make scary sounds too! Rawr! Mrow! That’ll show ‘em what’s what.
Meeting for the first time.
Cat girl: Hey bestie!
Horse girl: What?
Cat girl: Scoot over, gimme some room to sit.
Horse girl: Hello?
Cat girl, curls up in a ball.
Horse girl: Pardon me, has anyone lost a- What’s your name?
Tiger found caged in abandoned home gets second chance at wildlife sanctuary: ‘He seems to be so happy’
The estimated 350-pound tiger was transported to the facility, an
affiliate of the Humane Society of the United States, on Wednesday
afternoon, and is settling in well, Almrud said. There, he will have the
chance to roam in enclosures of up to three acres.
Almrud, who estimates him to be about 2 years old, described the
moment he first walked onto the grass at the sanctuary as remarkable.
“It was just amazing to see him walk out on grass and to see him explore
and have that freedom of movement,” she said. “It was just such a
reward and fulfilling to us.”
Now, he spends his days rolling around the grass in glee, Almrud said.
“He comes right up to the fence every time a staff member is present,” she said. “He seems very amenable to our presence.”
The tiger is eating well – a combination of chicken, humanely raised
non-processed beef and whole prey complete with organs and bones. It
appears that he was being fed chicken, which is what owners of exotic
cats often feed them, but chicken alone does not provide the complete
nutrition they need to thrive, Almrud said.
In addition, caregivers are tasked with keeping the tiger mentally
stimulated by creating “pretend hunting” games and rotating him through
different areas so he has access to new smells and environments to
explore.
“He seems to happy and content,” Almrud said. “Our staff is just falling in love with him.”
Wormweirds are delicate, dangerous creatures, resembling nothing so much as large, fragile slugs. They don’t move much, and almost never around other people, as their glomphing, oozing method of locomotion is rather undignified, and wormweirds are very, very conscious of their dignity. They prefer to perch in one place, often for years at a time. Roads have occasionally been built with previously unplanned corkscrews and roundabouts to avoid disturbing a settled wormweird. They are capable of digesting startling things, including wood and rock, and deriving nutrients from them.
Highly intelligent, capable of performing complex calculations both mathematical and political, wormweirds are valued as accountants, advisors, astronomers, theoretical physicists, and other such cerebral occupations, and held in an almost superstitious awe. The protruding head appendages are tied around with beads and charms, and serve as a symbol of age and rank—the more impressive the pigtails, the older and more highly esteemed the wormweird.
How these creatures reproduce is unknown, and their genders are obscure. While some use the male pronoun, and some the female, it’s not consistent across languages—a given wormweird might be “he” in one language and “she” in the next. If there is a wormweird language, nobody but the wormweirds speak it. Nobody has ever seen a baby wormweird, or if they have, they haven’t recognized it as such. At least one naturalist wrote a paper proposing that they might reproduce, as some slugs do, via a hermaphroditic dance with dueling, sword-like genitalia. They found the body eventually.
Well, most of it, anyway.
Research into that area has been pursued only carefully, and with utmost discretion, ever since.
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Just a doodle of a critter based on the one from the painting “It Gnaws the Walls” which was in turn based on this freaky dream I had once about these giant silkworms with women’s faces living under my office building and eating people when they tried to move their desks. In retrospect, I don’t think I liked that job very much. - Ursula Vernon
A stunning image by the Landscape photographer of the year for 2022, featuring the Dragon's Back landforms of the Peak District in the UK. Photo from a gallery at The Guardian.
"An Ohio sheriff’s lieutenant has apologized – and been merely reprimanded – after authoring social media posts boasting about how he would refuse to assist people who voted for Democrats during Tuesday’s elections and would require proof of a person’s voting choice before providing aid.
John Rodgers, a veteran lieutenant with the Clark county sheriff’s office, reportedly posted on Facebook that he would consider a person’s voting record when responding to calls for service in his jurisdiction, which includes the city of Springfield that has recently been at the center of conservative conspiracy theories, according to the Ohio news outlet WHIO.
In a series of posts, Rodgers reportedly wrote: “I am sorry. If you support the Democrat Party I will not help you.”
In another post, he reportedly said: “The problem is that I know which of you supports the Democratic Party, and I will not help you survive the end of days.”
And in another, WHIO reported, Rodgers indicated people would need to “provide proof of who you voted for” if they asked him for help."
