Shared posts
Oxford Malaria vaccine proves highly effective in trials
Languishing
Adam Grant, There’s a Name for the Blah You’re Feeling: It’s Called Languishing:
At first, I didn’t recognize the symptoms that we all had in common. Friends mentioned that they were having trouble concentrating. Colleagues reported that even with vaccines on the horizon, they weren’t excited about 2021. A family member was staying up late to watch “National Treasure” again even though she knows the movie by heart. And instead of bouncing out of bed at 6 a.m., I was lying there until 7, playing Words with Friends.
It wasn’t burnout - we still had energy. It wasn’t depression — we didn’t feel hopeless. We just felt somewhat joyless and aimless. It turns out there’s a name for that: languishing.
Languishing is a sense of stagnation and emptiness. It feels as if you’re muddling through your days, looking at your life through a foggy windshield. And it might be the dominant emotion of 2021.
Yeeeeeep. Yep. Yep. 1000% how I’ve been feeling today and on and off for months now.
Tags: Adam GrantDerek Chauvin found guilty on all counts of George Floyd’s murder
A Helicopter Flies on Mars
Deployed from NASA’s Perseverance rover, the Ingenuity helicopter took off and hovered for about 30 seconds in its first flight early this morning.
The solar-powered helicopter first became airborne at 3:34 a.m. EDT (12:34 a.m. PDT) — 12:33 Local Mean Solar Time (Mars time) — a time the Ingenuity team determined would have optimal energy and flight conditions. Altimeter data indicate Ingenuity climbed to its prescribed maximum altitude of 10 feet (3 meters) and maintained a stable hover for 30 seconds. It then descended, touching back down on the surface of Mars after logging a total of 39.1 seconds of flight. Additional details on the test are expected in upcoming downlinks.
Ingenuity’s initial flight demonstration was autonomous — piloted by onboard guidance, navigation, and control systems running algorithms developed by the team at JPL. Because data must be sent to and returned from the Red Planet over hundreds of millions of miles using orbiting satellites and NASA’s Deep Space Network, Ingenuity cannot be flown with a joystick, and its flight was not observable from Earth in real time.
NASA livestreamed the team in Mission Control as the test results were transmitted back to Earth. The photo above is of Ingenuity’s shadow taken while in flight by its onboard camera.
Update: Here’s video footage of the first flight:
And there’s always room for a little Great Span on this site. Alex Knapp:
Tags: astronomy Ingenuity Mars NASA Perseverance science spaceThe world’s oldest living person was alive when the Wright Brothers flew at Kitty Hawk and when the first helicopter flew on Mars.
Katalin Kariko, the Scientist Behind the Groundbreaking mRNA Vaccines
The NY Times has a profile of Dr. Katalin Kariko, who struggled for decades against a system unwilling to consider and fund her ideas about how messenger RNA could be used to instruct cells inside human bodies to “make their own medicines”. Her work has culminated in two highly effective vaccines for Covid-19 and is being extended to produce possible vaccines for HIV, the flu, tuberculosis, and malaria.
Now Katalin Kariko, 66, known to colleagues as Kati, has emerged as one of the heroes of Covid-19 vaccine development. Her work, with her close collaborator, Dr. Drew Weissman of the University of Pennsylvania, laid the foundation for the stunningly successful vaccines made by Pfizer-BioNTech and Moderna.
For her entire career, Dr. Kariko has focused on messenger RNA, or mRNA — the genetic script that carries DNA instructions to each cell’s protein-making machinery. She was convinced mRNA could be used to instruct cells to make their own medicines, including vaccines.
Stat also wrote a piece about Kariko and the development of the mRNA vaccines. It seems like Kariko will be strongly considered for a Nobel Prize in Chemistry for her achievements. The Covid vaccines will save hundreds of thousands of lives alone, and if mRNA can indeed be harnessed to protect against HIV and malaria, the effect on the world will be immense. Give Kariko all the prizes and whatever she wants to be happy in life — she’s earned it and more.
Update: From Derek Thompson at The Atlantic, How mRNA Technology Could Change the World.
Tags: COVID-19 Katalin Kariko medicine science vaccinesBut mRNA’s story likely will not end with COVID-19: Its potential stretches far beyond this pandemic. This year, a team at Yale patented a similar RNA-based technology to vaccinate against malaria, perhaps the world’s most devastating disease. Because mRNA is so easy to edit, Pfizer says that it is planning to use it against seasonal flu, which mutates constantly and kills hundreds of thousands of people around the world every year. The company that partnered with Pfizer last year, BioNTech, is developing individualized therapies that would create on-demand proteins associated with specific tumors to teach the body to fight off advanced cancer. In mouse trials, synthetic-mRNA therapies have been shown to slow and reverse the effects of multiple sclerosis. “I’m fully convinced now even more than before that mRNA can be broadly transformational,” Özlem Türeci, BioNTech’s chief medical officer, told me. “In principle, everything you can do with protein can be substituted by mRNA.”
The Cursed Computer Iceberg Meme
MerijnFantastic list of computer oddities, sorted from well-known to obscure & horrifying.
Have I Been Zucked?
NYT on the Trump campaign’s dark design patterns for fundraising
Stop Motion Lego Chocolate Cake
Watch as YouTuber tomosteen makes a Lego chocolate cake out of Lego ingredients, from cracking the eggs to the frosting on top. The little details here are *chef’s kiss*: the transitions from food to Lego brick, the way the chocolate bar breaks imperfectly, the little peaky dollop left after piping the chocolate frosting out of the pastry bag.
Don’t care for chocolate cake? How about a Japanese breakfast (featuring tamagoyaki) or churros instead?
See also Lego In Real Life or search for Lego in real life on YouTube. (via colossal)
Tags: Legos stop motion videoPirating the Oscars: Pandemic Edition
For nearly two decades, I’ve tracked the illicit distribution of Oscar-nominated films online to learn how the film industry’s new and innovative ways of thwarting pirates inevitably fail.
The end result is this spreadsheet, now documenting 611 Oscar nominees from the last 19 years, with metadata for every aspect of their online journey from handheld camcorder recordings in the theater to 4K Blu-Ray rips, and everything in between.
I used to do analysis every year, but after a five-year break, I thought it was worth coming back to revisit this incredibly strange year.
The pandemic touched every aspect of our lives and the film industry was no exception. As theaters closed nationwide, theatrical releases were delayed, forcing some studios to release their films as rentals, while others partnered with streaming services like Disney+, Hulu, and Netflix for exclusive streaming rights.
With theaters closed, a common source of low-quality camcorder leaks dried up, and the floodgates opened to a new one: theatrical releases in our homes on release day.
This year, the pandemic spawned two trends that shattered all records since I started tracking this data in 2003, seemingly in conflict with one another:
- Fewer screeners leaked online than ever, with only 9% of screeners leaking compared to 32% the previous year.
- Nominated films leaked online faster than ever, in a median 7 days between first release to leak, compared to 73 days the previous year.
At first glance, it seems like the MPAA finally beat the pirates at the screener game. The blue line in the chart below shows that a record low of 9% of this year’s nominees had Oscar screeners leaked online, continuing a downward trend.
But the red line tells a different story: that fully 97% of nominees, all but one film, have already leaked online in a high-quality format.
So what’s going on here? Let’s take a look at the data to understand the unique impact of the Covid-19 pandemic on how movies were released and leaked online.
Death of the Screener
When I first started tracking this data, DVD screeners were highly desirable because they were an opportunity to leak a high-quality version of the film months before its home video release, often while it was still in theaters.
Five years ago, I wrote about how screener desirability was changing as pirates were increasingly getting access to higher-quality 720p/1080p versions of films than Academy voters, who were stuck with 480p DVDs. In 2015, I wrote that “a staggering 44% of this year’s crop of nominees leaked as a high-quality rip from some source outside of traditional screeners or retail releases — the highest percentage since I started tracking films in 2003.”
For the second year in a row, most screeners were available digitally. Instead of just Best Picture nominees this year, virtually every nominated film was available for streaming by Oscar voters this year. But as far as I can tell, only three of those easier-to-access digital screeners leaked online. Why?
This year, the vanishing window between theatrical and streaming release dates made screeners completely meaningless. Why would anyone risk waiting to pirate an Academy screener when they could get the exact same quality sooner from Netflix, Hulu, Amazon Prime Video, or a streaming rental service?
The key chart is below, showing how the median number of days between the U.S. theatrical release date to its first high-quality rip, typically from a streaming site, cratered in 2020.
The theatrical window stayed remarkably consistent for the last five years at around 75 days. In 2020, it was seven days — a mere week from theatrical release to an HD stream rip, simply because virtually every movie was released online.
So, that’s basically it. With every theater closed, most movies first released online and on streaming services, making them instantly available to pirates before screeners were even distributed to voters, making screeners moot.
The big question: what will happen when the pandemic recedes and theaters reopen? Will studios push for once again staggering release dates between theatrical and streaming debuts? Is the 90-day window gone for good? Will the leaked screener make a comeback?
Let’s find out together in 2022. Stay tuned!
Why Grandmasters Are Playing the Worst Move in Chess
Read more of this story at Slashdot.
Chess world champion Magnus Carlsen plays 'Bongcloud Attack' meme opening in tournament
When Nakamura saw the stupid move, he couldn't stop laughing and matched Carlsen's stupid play beat for beat. The two chess champions laughed themselves silly while the commentators stammered in shock: Both men had deployed the Bongcloud Attack, one of chess' worst possible opening moves.It's called the Blongcloud Attack because it's a move so stupid only somebody high off their mind would actually come up with it.
As a meme opening, the Bongcloud Attack goes against basic principles of chess strategy. White blocks the diagonals for the bishop and queen and loses the ability to castle, putting the king in danger. Other openings in which either player makes an unorthodox king move within the first three moves have also been dubbed the Bongcloud.Both of them had already qualified for the next round so they were just messing around, but it's fun to see super high level people goofing like this. And by "goofing like this" I mean deploying my own personal chess strategies which have netted me a negative Elo rating. Didn't know negative Elo ratings were even possible? I don't like to brag, but they weren't until I came around. Keep going for the video clip of the two grandmasters cracking up.
A Drone’s Eye View of a Bowling Alley
The very first sequence of this video is of the camera — presumably perched on a drone — dropping out of the sky, flying through the door of beloved Minneapolis institution Bryant Lake Bowl, and following a bowling ball down the lane…and it just keeps going from there. Great drone piloting, choreography, sound design, and execution of concept. (via @brianmcc)
Update: ILM visual effects artist Todd Vaziri added Star Wars sound effects to the original video. He links to a few other remixes in this thread (like this Naked Gun one).
Tags: bowling videoDeepfaked Tom Cruise breakdown
CodeSOD: Last One In
A lesson that everyone learns at some point is "don't write your own authentication code." Authentication, like encryption, and like dates, is incredibly complex and has all sorts of ways you can subtly mess it up and not realize your mistake.
Take, for example, this code from Christopher. His peer wrote this code, added a single test record to the database, saw that it worked, and called it a day.
public void Login(string userName, string hashValue)
{
SqlDataReader dr = getUsers();
while (dr.Read())
{
if (dr["userName"].ToString() == userName && dr["hashPassword"].ToString() == hashValue)
{
this.authenticated = true;
}
else
{
this.authenticated = false;
}
}
}
Christopher spotted the core problem, and tried to explain it to the developer. When it wasn't sinking in, he quickly whipped up a script to add tens of thousands of users to the table, keeping the developer's username as the last row in the table. They could still log in, but logging in took much longer.
"Maybe I need to add an index?" was their response.
Christopher added one more row to the database, and now the developer was no longer able to log in.
"I don't understand? Why did it stop working?"
"You're looking at every row, and setting this.authenticated
for each one. So the only one that ends up counting is the last one."
The lightbulb finally went on, but it wasn't a particularly bright one. "Oh, right, I should add a break
if it matches!"
"Or," Christopher said, "let me tell you about a little thing called a WHERE
clause…"
Six Days
Client: Heads up. We have a new project coming in, and you have six days to finish it.
Me: (solo graphic designer) It? What is it?
Client: Graphic brand refresh for a concept department store for (major private developer). They also want us to have final artwork for signage and environmental graphics ready by then.
Me: …Is this project confirmed?
Client: Almost. We’ll know in about half an hour.
Me: Well then, heads up – you have half an hour to line up a backup designer, because if it really is six days, I’ll quit on the spot.
The post Six Days appeared first on Clients From Hell.
The Competitive Quartet
Salut Salon is a German musical quartet that plays classical music with a “passionate virtuosity, instrumental acrobatics, charm and a great sense of fun”. For a little taste of their vibe, check out this video of the four of them playing Vivaldi’s Summer with a mock competitive spirit that escalates with increasingly outlandish & impressive performances. This article calls Salut Salon “the Harlem Globetrotters of piano quartets” and that’s pretty accurate. (via @M10MacTen)
Tags: music Salut Salon videoDaft Punk has broken up
Sgt. Pepper Photos
Twitch Censors Live Metallica Performance with Dorkiest Music Imaginable
Read more of this story at Slashdot.
Yeah, no
Every year for the past three years I have picked up a 6 week contract with a training organization to develop their marketing materials for the year. They pay really well and have been quite good to work for.
This year I came in and saw there was a new GM. No biggie – he seemed pretty normal. I spent my first day being “on boarded” as I do every year. The GM’s deputy presented the code of conduct and the agreement to sign. I had a hunch that I had best have a read through just in case.
Sure enough, a new section appeared in this years edition: Prohibited Business Relations. Essentially it provided a list of every LGBTIQ+ affirming business in a 30-mile radius and stated that if we engaged with any of these businesses either privately or on behalf of the company, we would be dismissed. Amongst the businesses listed was my brother’s salon and my cousin’s tattoo parlour.
I declined to sign and ended my relationship with them there and then.
The post Yeah, no appeared first on Clients From Hell.
Smac McCreanor’s Hydraulic Press dance videos
Retired Librarian
I’m a retired librarian, and while I was never a freelancer I think this story will resonate with a Clients From Hell audience.
One day, I was sitting at my desk where I was providing library services for a U.S. Federal agency.
My boss came in and told me that the Federal Agency has submitted a report to the United Nations. The U.N. Returned it asking for the bibliography they’d used to write it.
My job was to do a literature search and find articles that supported their point of view and append them to the paper as if they’d actually done research before writing it.
It’s good to be retired.
The post Retired Librarian appeared first on Clients From Hell.
CD Projekt Red suffers cyber attack, Cyberpunk 2077 source code reportedly stolen
The Covid-19 Vaccines Are Amazing. Let’s Quickly Get Them into People’s Arms.
You probably read something yesterday, maybe just a headline, about Moderna’s Covid-19 vaccine being “six times less effective” against the B.1.351 coronavirus variant first identified in South Africa. This is, to put it plainly, a bullshit take on what is actually excellent news. This is the important bit, via Stat:
Both the Moderna vaccine and the immunization from Pfizer-BioNTech produce such powerful levels of immune protection — generating higher levels of antibodies on average than people who recover from a Covid-19 infection have — that they should be able to withstand some drop in their potency without really losing their ability to guard people from getting sick.
“There is a very slight, modest diminution in the efficacy of a vaccine against it, but there’s enough cushion with the vaccines that we have that we still consider them to be effective,” Anthony Fauci, the top U.S. infectious diseases official, said Monday on the “Today” show.
Let’s hear that again: “Both the Moderna vaccine and the immunization from Pfizer-BioNTech produce such powerful levels of immune protection…” These vaccines are so good, so potent, that even this sixfold drop in one measure of the vaccines’ ability to neutralize this one SARS-CoV-2 variant isn’t even enough to significantly reduce their overall protective power.1 That’s the important news here, that’s the very good news, that’s what you should be taking away from this. We have miraculously developed a near-perfect medicine for a plague that has significantly disrupted all human life on Earth and we’re flipping out over some technical details that the experts assure us don’t mean much in terms of overall effectiveness?! No thank you. Not today.
In a Twitter thread, Zeynep Tufekci is tearing her hair out because of the media’s misunderstanding and sensationalization of the “sixfold drop”.
I know people are tired but needless anxiety isn’t helping us. Let’s focus on getting through these months — better masks if indoors with others, more strict attention to our precautions — and the real problem: making more of these amazing vaccines quickly & getting them out there!
I get it, we want to understand but not how it works. Stop worrying about Nab titers. That does NOT mean the vaccine is six times less effective. People whose job it is to worry about it are on it & we just got confirmation: it works against the variants.
Plea to media: this isn’t a good headline. It makes people think the vaccine is six times less effective against the new variants (FALSE!) when the news today is *excellent*: The vaccine continues to work well against the new variants. That’s the headline.
For a much more technical take on the efficacy of the vaccines against variants, see virologist Florian Krammer’s long thread. His conclusion:
mRNA vaccines induce very high neutralizing antibodies after the second shot (consistently in the upper 25-30% of what we see with convalescent sera). If that activity is reduced by 10-fold, it is still decent neutralizing activity that will very likely protect. Furthermore, we know that the mRNA vaccines are already protective after the first shot when neutralizing antibody titers are low or undetectable in most individuals.
There is a concern here and it’s that B.1.351 or B.1.1.7 might mutate into variants that are significantly resistant against the vaccines’ good effects. Krammer again:
First, we need to do what every good scientist is praying for a year now: We need to cut down on virus circulation. The more the virus replicates, the more infections there are the higher are the chances for new variants to arise. Also, we need to try and contain B.1.351 and B.1.1.248/P.1 as much as possible.
That’s why, aside from preventing hundreds of thousands of deaths in the next several months, getting these vaccines into people’s arms is so important: the less the virus spreads, the less opportunity it will have to mutate into something even more dangerous. The US vaccination effort is slowly ramping up — we’re at an average of 1.3 million doses per day right now and the trend is heading in the right direction. We can get this done!
So what can you do about this right now? 1. Stop worrying about the variants until the experts let us know we have something to worry about. 2. If you are eligible for the vaccine, get it! 3. Spread the word about vaccine availability in your area. Yesterday Vermont opened signups for vaccination appointments for all Vermonters 75 and older, and I texted/emailed everyone I could think of who was over 75 or who had parents/relatives/friends who are over 75 to urge them to sign up or spread the word. 4. Continue to wear a mask (a better one if possible), wash your hands, social distance, stay home when possible, don’t spend time indoors w/ strangers, etc. Thanks to these remarkable vaccines, real relief is in sight — let’s keep on track and see this thing through.
Obviously, this could change! But the situation right now w/r/t variants is very good.↩
Three Quick Links for Friday Evening
MerijnTrump got permabanned from twitter after inciting a civil riot and people stormed the Capital building
Michael Apted, the director of the Seven Up documentary series, has died at the age of 79. [hollywoodreporter.com]
Twitter just permanently banned Donald Trump. “We have permanently suspended the account due to the risk of further incitement of violence.” [blog.twitter.com]
---
Note: Quick Links are pushed to this RSS feed twice a day. For more immediate service, check out the front page of kottke.org, the Quick Links archive, or the @kottke Twitter feed.
A racy request
I’m a makeup designer for a local live theatre, I have my services advertised on the internet. A supervisor from some branch business calls us.
Client: Would you do complicated makeup for non-actors? Say, applying full body makeup on office workers?
Me: I suppose you could do that. What kind of makeup would you need to be applied on office workers?
Client: Well we have a problem. Our executive-level manager will be visiting our branch later this month and all our employees are White. It wouldn’t look good if there were no employee diversity at our location. If we hired you could you work your magic on a few of our employees to make them look Black, or Chinese, or some other minority race?
YIKES. What’s the most insane thing a client has asked you?
The post A racy request appeared first on Clients From Hell.
How Bad Is Your Spotify?
MerijnUnsurprisingly, my Spotify was 'bad' because there's a ton of children's music on it
Bayhem email blast
Client: I want this newsletter to look really slick. Think “Transformers” movies.
I think he meant “sleek and modern,” but I coul only read that as “cluttered and loud.”
And by the tenth revision, turns out I was right.
The post Bayhem email blast appeared first on Clients From Hell.