Cary

ms-demeanor:

Hey you know how I said I was going to make a workbook on the kind of bullshit you need to do when someone you love dies? I actually did that.

HERE IS THE VERSION WITH LOTS OF SWEARING AT THE USELESS, SHITTY SITUATION YOU’RE IN.

HERE IS THE VERSION WITH A FAIR AMOUNT OF BLACK HUMOR BUT NO CURSEWORDS.

Featuring Helpful Sections such as:

• Death Certificates – What you need, why you need them, and how to get them
• Prepare to spend a long and miserable time on the phone
• What the Everloving Fuck is Probate
• Some Simple Dos and Don’ts
• Shitty Mad Libs – Templates for writing Obituaries and Memorials
• How to plan a non-religious death party
• So you suddenly have to become some sort of hacker or some shit

This is an eighteen page book that you can print out, download, share, and give away; it is meant to be used to collect information about funeral planning and account management after a death OR you can use it BEFORE you die and give people information so they’re not stuck playing Nancy Fucking Drew while trying to keep seventeen cousins who crawled out of the woodwork from gutting each other in front of the fucking casket as they argue about who’s inheriting grandma’s favorite dentures.

It’s not exactly cheerful and it’s full of things that are probably going to feel really fucking raw if you’re processing a fresh death.

I’m sorry! I love you! Death is shitty! I’m trying to laugh about it a little and I hope you can laugh a little too because otherwise we’re all just going to cry together.

Good luck!

(in memory of my weirdo mother and her weirdo siblings who all died too fucking young and left me holding this flaming bag of dogshit)

beggars-opera:

Portrait of “O-o-dee”, Oklahoma City, c.1894

wizard-council-bureaucrat:

the-god-of-magic:

Wizard Fact #42: The real reason you’re not supposed to stick a fork into your toaster is because you might stab one of the wizards in there

and they will instantaneously retaliate with a level 8 Chain Lightning, as is their right

somecutething:

What happens when you take a break at an animal rescue.

(via Reddit)

vaspider:

vaspider:

astridflies:

moreclaypigeons:

otteroflore:

rosslynpaladin:

spooniestrong:

“Inverse vaccine” shows potential to treat multiple sclerosis and other autoimmune diseases

Is this a prank? What….

Edit: holy heck it’s real…

They might be able to help us…

The stage that they’re at is animal testing but it sounds like it’s been successful in mouse and primate models.

My understanding: The way autoimmune diseases usually seem to work* is the immune system is “flagging” the wrong thing as harmful/not needed and destroying it. The typical treatments for autoimmune diseases are just tamping the entire immune system down so it can’t destroy anything, which leaves a person vulnerable to infection.

The newer method is basically “tricking” the body using a method that… the human body already came up with. Cells flagging the wrong thing apparently happens all the time, so there are multiple defenses against immune disease, and one of them is in the liver. So scientists figured out a way to tell the body “hey, you flagged this wrong” and sent it to the liver and the liver/body recognized this signal.

There is still a lot of work to be done and it sounds like this isn’t foolproof (ie: what if the liver is whats broken? unsure, and what if the immune system flags things wrong again?) but this is literally so amazing. i was tearing up reading it, and i hope that everything goes well in clinical trials.

*theres like a lot medical science doesnt know about the immune system

Thank you for this explanation/synthesis of the article! It’s important for us to understand that they’re still in early development and testing of these methods, but also that they’ve seen it work in mice and primates (rather than just petri dishes of human cells). I hope this goes well.

Hi! I’m a microbiologist and I’ve done work in academia, pharma, and clinical trials.

So the most exciting thing about this article is the last paragraph tbh (working on getting the actual paper, it’s not up on sci-hub yet).

The company mentioned, Anokion, has four registered clinical trials for both Celiac and MS patients. The trial for Celiac just submitted data from their phase 1 trial (meaning there’s good data it is safe) and are recruiting for a Phase ½ trial (meaning they are now testing efficacy). After that, the big hurdle is phase 3, which looks at whether or not it is better than a current treatment. The projected completion date is spring 2025. They are also preparing for a Phase 2 trial but are not yet recruiting.

The phase 1 MS trial is currently active, estimated completion in summer 2024.

I checked the company website and it looks like they are in the process of submitting an investigational new drug (IND) application for Type 1 diabetes. This is the first step to starting clinical safety and efficacy trials.

Now clinical trials can get delayed for a variety of reasons, but this is a really good sign! It’s way further along than I initially thought when seeing the news. If the treatment does well, we could see new drugs on the market for Celiacs as early at 2030ish and MS as early as 2035.

I literally just burst into tears and woke up my partners.

Holy shit. The idea of not having celiac disease anymore is so completely overwhelming.

Update: I have registered for the trial and if you also have celiac and want to register the link is here.

carouselcometh:

Devastating! Art museum gift shop doesn’t sell prints of specific and unpopular painting that struck a cord with you!

dessalines-raised-sword:

I forgot to share this on the right day but still important anniversary.

sighinastorm:

“You don’t have to be that gung-ho on trans rights to realize that a world where girls’ genitals need to be inspected before they can play any sport is worse for girls than a world where once in a while there’s a trans girl on a girls’ team.” —Evan Urquhart

scientia-rex:

densoro:

only-cat-memes:

CHIM-CHIM-CHEROOOOO

tricky-pockets:

tricky-pockets:

tricky-pockets:

tricky-pockets:

fucking adhd. I have to run a con on my own brain to get anything done.

I’m staging everything I’ll need to do paperwork and a stressful phone call, real sneaky-like so as not to alert my brain to the plan. Going into the kitchen for coffee and casually turning on my computer as I pass. Telling myself I’m just picking up these papers so I don’t step on them. Planting my favorite pen in a strategic position.

Later, I’ll subtly imply that completing this task is quick, it’s easy, and it’s free. And then I’ll see everything laid out and think “well, surely a little 5-minute trial run won’t hurt, and of course I can stop if I want to.” and that’s when the bear traps will be activated.

and maybe you’re thinking nobody would fall for that but lemme tell ya: I know the mark and he’s a real goober. you can trick him into taking pills just by placing them on top of a package of mint oreos. he doesn’t even question it, just finds the pills on his way to the cookies and goes “sure, why not?”

owlservice:

ascle:

Un p’tit mardi dans la vie d’une calico!

Causal friday in a calico’s life!

I love what a bastard this kitten is

ALT

ALT

Me too, little angel

sorryhahaifellasleep:

moldavite:

why is this about to make me sob

a poem i am sure everyone has seen but i’m still going to share anyway

as well as this other poem inspired by giovanni’s

and this beautiful tweet

humblegrub:

a mini cat tree for a tiny arachnid kitty

catchymemes:

creamypancakebatter:

compassionatereminders:

It’s a lot healthier to go for a daily walk than to sign up for a gym membership you won’t be using because you hate that kind of exercise. It’s a lot healthier to eat a frozen meal than to skip a meal because you were too tired to cook something healthy. It’s a lot healthier to take a quick shower than to procrastinate an elaborate routine for days. Don’t aim so high that you won’t be hitting anything!

this is actually really helpful and affirming thanks

dadpilled:

dadpilled:

Think this often about my boy

Well if you are going to interact with my post look at my boy he’s everything to me

marinella-ela:

mrdyketator:

roomba-with-knives-taped-to-it:

Crying over these lesbian cats

LESBIAN CATS

daily-reminders-that-ur-enough:

You deserve rest, and rest is not optional. Rest is essential and if you do not rest enough then your body will choose a time regardless of your schedule. You deserve rest even if you haven’t ‘accomplished’ things, exhaustion can feel overwhelming and sometimes the best thing to do is do something fun and light. You deserve joy, even, and ESPECIALLY, as you take care of yourself.

Yeah it’s “meatloaf” bc I’ll do anything for love but I won’t do that

submissivefeminist:

I fucking love this????

only-tiktoks:

chaumas-deactivated20230115:

thanks to this workplace harassment training video my coworkers and I now say this to each other on a near-daily basis

Michigan ice cream ❤️

guineapiggies:

Via jacuueline

guooey:

Peace and LOVE on planet Earth

tashabilities:

micdotcom:

Watch: Poet G Yamazawa nails what it’s like to grow up in the U.S. as the child of immigrants.

That “only homework that our parents can help us with” knocked a pause in me, my gawd. 

centralbunnyunit: