Chemical Reviews
DOI: 10.1021/acs.chemrev.6b00274
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29 Oct 12:58
Oxetanes: Recent Advances in Synthesis, Reactivity, and Medicinal Chemistry
by James A. Bull, Rosemary A. Croft, Owen A. Davis, Robert Doran and Kate F. Morgan
23 Sep 19:19
Enantioconvergent catalysis
by Justin T. Mohr, Jared T. Moore and Brian M. Stoltz
Abstract
An enantioconvergent catalytic process has the potential to convert a racemic starting material to a single highly enantioenriched product with a maximum yield of 100%. Three mechanistically distinct approaches to effecting enantioconvergent catalysis are identified, and recent examples of each are highlighted. These processes are compared to related, non-enantioconvergent methods.
Beilstein J. Org. Chem. 2016, 12, 2038–2045. doi:10.3762/bjoc.12.192
18 Sep 13:31
HPLC-Assisted Automated Oligosaccharide Synthesis: Implementation of the Autosampler as a Mode of the Reagent Delivery
by Salvatore G. Pistorio, Swati S. Nigudkar, Keith J. Stine and Alexei V. Demchenko
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01439
tatsuya.suzuki.1016 likes this
18 Sep 13:30
Cobalt-Catalyzed Hydrosilylation/Cyclization of 1,6-Enynes
by Tuo Xi and Zhan Lu
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01555
Chenan, Leuchtkaefer and one other like this
18 Sep 13:28
Determining crystal structures through crowdsourcing and coursework
by Scott Horowitz
Determining crystal structures through crowdsourcing and coursework
Nature Communications, Published online: 16 September 2016; doi:10.1038/ncomms12549
Building crystal structures into the electron density is an important step in protein structure solution. Here, the authors recruit online game players, students, and experienced crystallographers to compete in a competition to solve a new structure, and find that crowdsourcing model-building works.
25 Aug 18:25
N-Oxides rescue Ru(V) in catalytic Griffith-Ley (TPAP) alcohol oxidations
Chem. Commun., 2016, 52,10301-10304
DOI: 10.1039/C6CC05440D, Communication
DOI: 10.1039/C6CC05440D, Communication
Timothy J. Zerk, Peter W. Moore, Craig M. Williams, Paul V. Bernhardt
Electrochemistry of tetrapropylammonium perruthenate (TPAP) reveals that an unstable Ru(V) complex is reoxidised by amine N-oxides in catalytic Griffith-Ley alcohol oxidations.
The content of this RSS Feed (c) The Royal Society of Chemistry
Electrochemistry of tetrapropylammonium perruthenate (TPAP) reveals that an unstable Ru(V) complex is reoxidised by amine N-oxides in catalytic Griffith-Ley alcohol oxidations.
The content of this RSS Feed (c) The Royal Society of Chemistry
18 Aug 21:22
Copper-Catalyzed Intramolecular Benzylic C–H Amination for the Synthesis of Isoindolinones
by Chiaki Yamamoto, Kazutaka Takamatsu, Koji Hirano and Masahiro Miura
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01393
18 Aug 10:59
Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst
by Sandra Medina, Matthew J. Harper, Edward I. Balmond, Silvia Miranda, Giacomo E. M. Crisenza, Diane M. Coe, Eoghan M. McGarrigle and M. Carmen Galan
Organic Letters
DOI: 10.1021/acs.orglett.6b01962
16 Aug 07:26
Flow Grignard and Lithiation: Screening Tools and Development of Continuous Processes for a Benzyl Alcohol Starting Material
by Michael E. Kopach, Kevin P. Cole, Patrick M. Pollock, Martin D. Johnson, Timothy M. Braden, Luke P. Webster, Jennifer McClary Groh, Adam D. McFarland, John P. Schafer, Jonathan J. Adler and Morgan Rosemeyer
Organic Process Research & Development
DOI: 10.1021/acs.oprd.6b00131
12 Aug 07:46
Development of Specific, Irreversible Inhibitors for a Receptor Tyrosine Kinase EphB3
by Alvin Kung, Ying-Chu Chen, Marianne Schimpl, Feng Ni, Jianfa Zhu, Maurice Turner, Henrik Molina, Ross Overman and Chao Zhang
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b05483
11 Aug 08:57
An histidine covalent receptor and butenolide complex mediates strigolactone perception
by Alexandre de Saint Germain
Nature Chemical Biology. doi:10.1038/nchembio.2147
Authors: Alexandre de Saint Germain, Guillaume Clavé, Marie-Ange Badet-Denisot, Jean-Paul Pillot, David Cornu, Jean-Pierre Le Caer, Marco Burger, Frank Pelissier, Pascal Retailleau, Colin Turnbull, Sandrine Bonhomme, Joanne Chory, Catherine Rameau & François-Didier Boyer
11 Aug 07:16
Alkylation of Sulfonamides with Trichloroacetimidates under Thermal Conditions
by Daniel R. Wallach and John D. Chisholm
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01421
XJ, Joaquin García Alvarez likes this
09 Aug 07:29
Diborane-Mediated Deoxygenation of o-Nitrostyrenes To Form Indoles
by Kai Yang, Fei Zhou, Zhijie Kuang, Guoliang Gao, Tom G. Driver and Qiuling Song
Organic Letters
DOI: 10.1021/acs.orglett.6b01934
05 Aug 11:52
A Homogeneous Method for the Conveniently Scalable Palladium- and Nickel-Catalyzed Cyanation of Aryl Halides
by Finn Burg, Julian Egger, Johannes Deutsch and Nicolas Guimond
Organic Process Research & Development
DOI: 10.1021/acs.oprd.6b00229
04 Aug 08:14
Sterically Encumbered Tetraarylimidazolium Carbene Pd-PEPPSI Complexes: Highly Efficient Direct Arylation of Imidazoles with Aryl Bromides under Aerobic Conditions
by Xu-Xian He, Yinwu Li, Bei-Bei Ma, Zhuofeng Ke and Feng-Shou Liu
Organometallics
DOI: 10.1021/acs.organomet.6b00391
04 Aug 08:02
Synthesis of a Small-Molecule Library with Skeletal Diversity from Hemslecin A via the Reaction-Discovery Strategy
by Jian Ren, Xin Shi, Xiao-Nian Li, Lai-Wei Li, Jia Su, Li-Dong Shao and Qin-Shi Zhao
Organic Letters
DOI: 10.1021/acs.orglett.6b01654
02 Aug 07:33
Copper-Catalyzed Enantioselective Addition of Styrene-Derived Nucleophiles to Imines Enabled by Ligand-Controlled Chemoselective Hydrocupration
by Yang Yang, Ian B. Perry and Stephen L. Buchwald
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b06299
01 Aug 13:48
Evolution of a Novel, Orally Bioavailable Series of PI3Kδ Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease
by Augustin Amour, Nick Barton, Anthony W. J. Cooper, Graham Inglis, Craig Jamieson, Christopher N. Luscombe, Josie Morrell, Simon Peace, David Perez, Paul Rowland, Chris Tame, Sorif Uddin, Giovanni Vitulli and Natalie Wellaway
Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00799
01 Aug 10:10
Resilient British science will withstand Brexit
by Ehsan Masood
Resilient British science will withstand Brexit
Nature 535, 7613 (2016). http://www.nature.com/doifinder/10.1038/535467a
Author: Ehsan Masood
UK scientists have had to fight to stay international before, and they must not stop now, says Ehsan Masood.
28 Jul 13:58
Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins
by Steven W. M. Crossley, Carla Obradors, Ruben M. Martinez and Ryan A. Shenvi
Chemical Reviews
DOI: 10.1021/acs.chemrev.6b00334
28 Jul 13:56
Synthesis of Tetrahydroisoquinoline Alkaloids and Related Compounds through the Alkylation of Anodically Prepared α-Amino Nitriles
by Lotfi Benmekhbi, Fadila Louafi, Thierry Roisnel and Jean-Pierre Hurvois
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01419
XJ likes this
26 Jul 20:57
11-Step Total Synthesis of (−)-Maoecrystal V
by Artiom Cernijenko, Rune Risgaard and Phil S. Baran
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b06623
26 Jul 14:21
MIDA boronates are hydrolysed fast and slow by two different mechanisms
by Jorge A. Gonzalez
Nature Chemistry. doi:10.1038/nchem.2571
Authors: Jorge A. Gonzalez, O. Maduka Ogba, Gregory F. Morehouse, Nicholas Rosson, Kendall N. Houk, Andrew G. Leach, Paul H.-Y. Cheong, Martin D. Burke & Guy C. Lloyd-Jones
The staged hydrolysis of N-methylimidodiacetic (MIDA) boronates is a prerequisite for their application in small-molecule constructions. Mechanistic studies now show that two distinct hydrolysis mechanisms operate in parallel, the partitioning — which is dependent on the pH, water activity and homogeneity of the medium — can be readily quantified by 18O incorporation.
Jorge Gonzalez, M. L. Lepage likes this
26 Jul 13:35
Discovery and in Vivo Evaluation of the Potent and Selective PI3Kδ Inhibitors 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-6-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-0687) and 2-((1S)-1-((6-Amino-5-cyano-4-pyrimidinyl)amino)ethyl)-5-fluoro-N-methyl-3-(2-pyridinyl)-4-quinolinecarboxamide (AM-1430)
by Felix Gonzalez-Lopez de Turiso, Xiaolin Hao, Youngsook Shin, Minna Bui, Iain D. G. Campuzano, Mario Cardozo, Michelle C. Dunn, Jason Duquette, Benjamin Fisher, Robert S. Foti, Kirk Henne, Xiao He, Yi-Ling Hu, Ron C. Kelly, Michael G. Johnson, Brian S. Lucas, John McCarter, Lawrence R. McGee, Julio C. Medina, Daniela Metz, Tisha San Miguel, Deanna Mohn, Thuy Tran, Christine Vissinga, Sharon Wannberg, Douglas A. Whittington, John Whoriskey, Gang Yu, Leeanne Zalameda, Xuxia Zhang and Timothy D. Cushing
Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.6b00827
26 Jul 08:48
Coinage Metal Hydrides: Synthesis, Characterization, and Reactivity
by Abraham J. Jordan, Gojko Lalic and Joseph P. Sadighi
Chemical Reviews
DOI: 10.1021/acs.chemrev.6b00366
Mickael.henrion, Xuzhen199 and one other like this
25 Jul 10:47
Design and Applications of an Efficient Amphiphilic “Click” CuI Catalyst in Water
by Changlong Wang, Dong Wang, Shilin Yu, Thomas Cornilleau, Jaime Ruiz, Lionel Salmon and Didier Astruc
ACS Catalysis
DOI: 10.1021/acscatal.6b01389
25 Jul 09:44
Highly Selective and Modular Synthesis of 3-Aryl-4-(arylethynyl)-2H-chromen-2-ones from 2-Iodoaryl 2-Arylacetates through a Carbonylative Sonogashira Coupling–Intramolecular Aldol Cascade Reaction
by Attoor Chandrasekhar, Venkatachalam Ramkumar, Sethuraman Sankararaman
A modular method for the synthesis of 3-aryl-4-(arylethynyl)-2H-chromen-2-ones from 2-iodoaryl 2-arylacetates and arylacetylenes has been developed. The carbonylative Sonogashira coupling–intramolecular aldol casade reaction was carried out in the presence of Pd(PPh3)2(Cl)2 as the catalyst. The one-pot approach that involves the in situ formation of the 2-iodoaryl 2-arylacetates from the corresponding 2-iodophenols and 2-arylacetyl chlorides followed by the palladium-catalyzed carbonylative annulation in the presence of the arylacetylene has also been described for the formation of the 3-aryl-4-(arylethynyl)-2H-chromen-2-ones.
A modular approach for the synthesis of 3-aryl-4-(arylethynyl)-2H-chromen-2-ones from iodoaryl 2-arylacetates and arylacetylenes has been developed. This highly selective general method was used to prepare 24 different 3,4-disubstitued 2H-chromen-2-one derivatives in good to excellent yields.
25 Jul 08:57
Scaffold Diversity through a Branching Double-Annulation Cascade Strategy: Iminium-Induced One-Pot Synthesis of Diverse Fused Tetrahydroisoquinoline Scaffolds
by Duddu S. Sharada, Anand H. Shinde, Srilaxmi M. Patel and Shinde Vidyacharan
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.6b01096
22 Jul 06:59
Palladium-Catalyzed Negishi Cross-Coupling Reaction of Aryl Halides with (Difluoromethyl)zinc Reagent
by Kohsuke Aikawa, Hiroki Serizawa, Koki Ishii and Koichi Mikami
Organic Letters
DOI: 10.1021/acs.orglett.6b01734
123rliu likes this
22 Jul 06:59
Copper-Catalyzed Difluoromethylation of Aryl Iodides with (Difluoromethyl)zinc Reagent
by Hiroki Serizawa, Koki Ishii, Kohsuke Aikawa and Koichi Mikami
Organic Letters
DOI: 10.1021/acs.orglett.6b01733