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21 Feb 14:00

Nickel-catalyzed formation of quaternary carbon centers using tertiary alkyl electrophiles

Chem. Soc. Rev., 2021, 50,4162-4184
DOI: 10.1039/D0CS01107J, Review Article
Weichao Xue, Xiao Jia, Xuan Wang, Xianghua Tao, Zhigang Yin, Hegui Gong
This review provides a comprehensive summary of recent advances in nickel-catalyzed reactions employing tertiary alkyl electrophiles for the construction of quaternary carbon centers.
The content of this RSS Feed (c) The Royal Society of Chemistry
07 Jul 14:09

Generation of all carbon quaternary stereocenters at the C-3 carbon of piperidinones and pyrrolidinones and its application in natural product total synthesis

Publication date: Available online 4 May 2018

Source: Tetrahedron

Author(s): Ganesh Pandey, Akash Mishra, Jagadish Khamrai

Abstract

Methodologies regarding the construction of an all carbon quaternary stereocenters at C-3 of lactams have posed significant challenges in the total synthesis of natural products. This review summarizes the advancements for the construction of an all carbon quaternary stereocenters at C-3 of piperidinones and pyrrolidinones and its application in the total synthesis of biologically active and architecturally complex alkaloids.

Graphical abstract

Image 1

01 Sep 01:16

Total Synthesis of (+)-Antrocin and Its Diastereomer and Clarification of the Absolute Stereochemistry of (−)-Antrocin

by Sheng-Han Huang, Kai-Hsiang Liang, Jia-Syun Lu, Wei-Sheng Chang, Ming-Der Su and Te-Fang Yang

TOC Graphic

The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.7b01600
28 Jul 14:44

Tuning the emission properties of a fluorescent polymer using a polymer microarray approach - identification of an optothermo responsive polymer

Chem. Commun., 2016, 52,10521-10524
DOI: 10.1039/C6CC04657F, Communication
Guirong Wang, Zongquan Duan, Yang Sheng, Kevin Neumann, Linhong Deng, Jian Li, Mark Bradley, Rong Zhang
Fluorescent polymer microarrays were prepared using inkjet printing and screened. The fluorescence intensity was found to be tunable by temperature change when the dye was immobilized in identified thermo-responsive polymer beads.
The content of this RSS Feed (c) The Royal Society of Chemistry
26 Jul 02:52

Diels–Alderase-free, bis-pericyclic, [4+2] dimerization in the biosynthesis of (±)-paracaseolide A

by Tao Wang

Nature Chemistry 7, 641 (2015). doi:10.1038/nchem.2281

Authors: Tao Wang & Thomas R. Hoye

The facile, spontaneous dimerization of a simple alkenylbutenolide monomer is relevant to the biosynthesis of racemic paracaseolide A. As supported by computation, a fully (C2-)symmetric, bis-pericyclic Diels–Alder cycloaddition transition state structure is invoked to account for the atypical exo-selectivity and room-temperature reactivity.