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15 Jul 12:13

Base-promoted dynamic amide exchange: efficient access to isotopically enriched tertiary amides

Chem. Sci., 2025, 16,15528-15536
DOI: 10.1039/D5SC02566D, Edge Article
Open Access Open Access
Quentin Lemesre, Rémi Blieck, Antoine Sallustrau, Timothée D'Anfray, Frédéric Taran, Davide Audisio
Amide isotope labeling is a crucial tool in drug discovery and development. This study presents novel strategies for amide isotope exchange. We leverage transamidation and amide metathesis to provide direct and efficient synthetic routes.
The content of this RSS Feed (c) The Royal Society of Chemistry
24 Apr 06:19

[ASAP] Artificial Intelligence-Assisted Optimization of Antipigmentation Tyrosinase Inhibitors: De Novo Molecular Generation Based on a Low Activity Lead Compound

by Hong Cai, Wenchao Chen, Jing Jiang, Hao Wen, Xinyu Luo, Junjie Li, Liuxin Lu, Rui Zhao, Xinhua Ni, Yinyan Sun, Jiahui Wang, Zhen Li, Bin Ju, Xiaoying Jiang, and Renren Bai

TOC Graphic

Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.4c00091