Riddle me this…
Installatoin view, Limbus. Hashimoto Contemporary
Over the last year or so, German street artist 1010 (previously) created several of his fantastic spray paint portals in locations around Germany, Panama, and the United States. 1010 brings surprising layers of depth to drab facades and blank gallery walls by painting concentric layers of color. The artist most recently had a solo show at Hashimoto Contemporary in San Francisco titled Limbus. You can see more over on Juxtapoz and on Facebook.
Here are some of my top wine picks.
A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.
A stereoselective aldol reaction of unactivated ketones and isocyanoacetate pronucleophiles is catalyzed by a binary catalyst system consisting of an aminophosphine precatalyst and silver(I) oxide and affords oxazoline products with a fully substituted β-carbon atom. The reaction is efficient and broad in scope and proceeds with high diastereo- and enantioselectivity.
Since Eurovision last year I’ve seen a ton of people confusing Conchita as a beacon of transgender pride and it’s always irked me. She isn’t transgender and has never claimed as such, as the image set here shows. She seems very respectful towards people who are, in fact, transgender, and I’m glad she’s taken so much time to clarify the difference between the drag persona of Conchita Wurst (and her male performer) and what being transgender actually is.
"Who has ever needed one of these after a meeting?" - Ross Hammond
A convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of azolium enolate intermediate, formaldehyde-derived iminium ion (as an electrophilic reactant), and methanol (as a nucleophilic reactant). This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.
Harmonious cooperation: An N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperatively catalyze the aminomethylation of α,β-unsaturated aldehydes. This cooperative catalytic reaction provides a redox neutral strategy for quick access to β2-amino esters in an enantioselective manner.
A three-component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of α-substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford γ-alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear-cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.
Three-component coupling of alkenes, alcohols, and alkyl nitriles catalyzed by copper triflate afforded 4-alkoxyalkyl nitriles in good to excellent yields. The reaction forms a CC and a CO bond with concomitant creation of a quaternary carbon center. The involvement of a radical intermediate was proven by a radical clock experiment.
(photo via evilsanta)