04 Mar 05:00

Insurance

LIFEHACKS: You can just take all the luggage off the airport conveyer belt and leave with it. They don't check that it's yours at the door!
04 Mar 10:00

How to respond about on-going outages

by sharhalakis
image

uaiHebert

03 Mar 20:00

Photo



05 Mar 10:00

When you think you have it under control

by sharhalakis

by uaiHebert

03 Mar 16:11

Ligand-Enabled β-C–H Arylation of α-Amino Acids Using a Simple and Practical Auxiliary

by Gang Chen, Toshihiko Shigenari, Pankaj Jain, Zhipeng Zhang, Zhong Jin, Jian He, Suhua Li, Claudio Mapelli, Michael M. Miller, Michael A. Poss, Paul M. Scola, Kap-Sun Yeung and Jin-Quan Yu

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/ja512690x
02 Mar 23:42

by Amazing Super Powers

02 Mar 22:30

batsvsupes:Riddle me this…









batsvsupes:

Riddle me this…

03 Mar 16:58

New Murals by ‘1010’ Expose Hidden Portals of Color in Walls and Buildings

by Christopher Jobson

1010-1
Installatoin view, Limbus. Hashimoto Contemporary

1010-7

1010-2

1010-3

1010-4

1010-5

1010-6

Over the last year or so, German street artist 1010 (previously) created several of his fantastic spray paint portals in locations around Germany, Panama, and the United States. 1010 brings surprising layers of depth to drab facades and blank gallery walls by painting concentric layers of color. The artist most recently had a solo show at Hashimoto Contemporary in San Francisco titled Limbus. You can see more over on Juxtapoz and on Facebook.

03 Mar 05:13

boom.



boom.

03 Mar 23:40

obviousplant:Here are some of my top wine picks.



















obviousplant:

Here are some of my top wine picks.

03 Mar 21:30

Tumblr

by brandpowder
03 Mar 20:10

Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates

by Raquel de la Campa, Irene Ortín, Darren J. Dixon

Abstract

A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.

Thumbnail image of graphical abstract

A stereoselective aldol reaction of unactivated ketones and isocyanoacetate pronucleophiles is catalyzed by a binary catalyst system consisting of an aminophosphine precatalyst and silver(I) oxide and affords oxazoline products with a fully substituted β-carbon atom. The reaction is efficient and broad in scope and proceeds with high diastereo- and enantioselectivity.

03 Mar 17:53

chima1675:AWESOME.



chima1675:

AWESOME.

03 Mar 03:32

hatpire:thefabulousconchitawurst:xSince Eurovision last year...







hatpire:

thefabulousconchitawurst:

x

Since Eurovision last year I’ve seen a ton of people confusing Conchita as a beacon of transgender pride and it’s always irked me. She isn’t transgender and has never claimed as such, as the image set here shows. She seems very respectful towards people who are, in fact, transgender, and I’m glad she’s taken so much time to clarify the difference between the drag persona of Conchita Wurst (and her male performer) and what being transgender actually is.

04 Mar 22:49

"Who has ever needed one of these after a meeting?" - Ross...



"Who has ever needed one of these after a meeting?" - Ross Hammond

04 Mar 00:06

03/02/15 PHD comic: 'Giant Leap'

Piled Higher & Deeper by Jorge Cham
www.phdcomics.com
Click on the title below to read the comic
title: "Giant Leap" - originally published 3/2/2015

For the latest news in PHD Comics, CLICK HERE!

03 Mar 23:04

percychekov:sirdef:northwangerabbey: Sulu’s like “whatever,...





percychekov:

sirdef:

northwangerabbey:

Sulu’s like “whatever, drama queen.”

is sulu texting

he’s livetweeting chekov’s problems

03 Mar 20:10

Aminomethylation of Enals through Carbene and Acid Cooperative Catalysis: Concise Access to β2-Amino Acids

by Jianfeng Xu, Xingkuan Chen, Ming Wang, Pengcheng Zheng, Bao-An Song, Yonggui Robin Chi

Abstract

A convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of azolium enolate intermediate, formaldehyde-derived iminium ion (as an electrophilic reactant), and methanol (as a nucleophilic reactant). This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.

Thumbnail image of graphical abstract

Harmonious cooperation: An N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperatively catalyze the aminomethylation of α,β-unsaturated aldehydes. This cooperative catalytic reaction provides a redox neutral strategy for quick access to β2-amino esters in an enantioselective manner.

03 Mar 10:10

Copper-Catalyzed Intermolecular Carboetherification of Unactivated Alkenes by Alkyl Nitriles and Alcohols

by Claire Chatalova-Sazepin, Qian Wang, Glenn M. Sammis, Jieping Zhu

Abstract

A three-component carboetherification of unactivated alkenes has been developed allowing the rapid building of complexity from simple starting materials. A wide range of α-substituted styrenes underwent smooth reactions with unactivated alkyl nitriles and alcohols to afford γ-alkoxy alkyl nitriles with concomitant generation of a quaternary carbon center. A radical clock experiment provided clear-cut evidence that the reaction proceeds through a tertiary alkyl radical intermediate.

Thumbnail image of graphical abstract

Three-component coupling of alkenes, alcohols, and alkyl nitriles catalyzed by copper triflate afforded 4-alkoxyalkyl nitriles in good to excellent yields. The reaction forms a C[BOND]C and a C[BOND]O bond with concomitant creation of a quaternary carbon center. The involvement of a radical intermediate was proven by a radical clock experiment.

03 Mar 10:00

Following market trends

by sharhalakis

by uaiHebert

03 Mar 05:16

Photo



03 Mar 05:15

(photo via evilsanta)



(photo via evilsanta)

03 Mar 04:40

Photo







03 Mar 02:00

bae: tell me your wildest fantasy

bae: tell me your wildest fantasy
me: i'm financially stable in a job that i love with great opportunities for career advancement. i live in a modest home with a good sized yard and a fence for my dogs, there are hardly any problems with the home, but sometimes the garbage disposal clogs. the fridge and pantry are never empty and when they're getting low, i can go to the grocery store at my leisure. my pre-owned car never makes funny noises and when it does, i have the money to take it to the mechanic. i am in good health and most days, i have the energy to carry out my daily tasks and do some things i enjoy as well.