"Who has ever needed one of these after a meeting?" - Ross Hammond
Here are some of my top wine picks.
A catalytic asymmetric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles has been developed. A quinine-derived aminophosphine precatalyst and silver oxide were found to be an effective binary catalyst system and promoted the reaction to afford chiral oxazolines possessing a fully substituted stereocenter with good diastereoselectivities and excellent enantioselectivities.
A stereoselective aldol reaction of unactivated ketones and isocyanoacetate pronucleophiles is catalyzed by a binary catalyst system consisting of an aminophosphine precatalyst and silver(I) oxide and affords oxazoline products with a fully substituted β-carbon atom. The reaction is efficient and broad in scope and proceeds with high diastereo- and enantioselectivity.
Installatoin view, Limbus. Hashimoto Contemporary
Over the last year or so, German street artist 1010 (previously) created several of his fantastic spray paint portals in locations around Germany, Panama, and the United States. 1010 brings surprising layers of depth to drab facades and blank gallery walls by painting concentric layers of color. The artist most recently had a solo show at Hashimoto Contemporary in San Francisco titled Limbus. You can see more over on Juxtapoz and on Facebook.
my coworker and i discovered something…
(tweet by Mindy Furano)
A convergent, organocatalytic asymmetric aminomethylation of α,β-unsaturated aldehydes by N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperative catalysis is disclosed. The catalytically generated conjugated acid from the base plays dual roles in promoting the formation of azolium enolate intermediate, formaldehyde-derived iminium ion (as an electrophilic reactant), and methanol (as a nucleophilic reactant). This redox-neutral strategy is suitable for the scalable synthesis of enantiomerically enriched β2-amino acids bearing various substituents.
Harmonious cooperation: An N-heterocyclic carbene (NHC) and (in situ generated) Brønsted acid cooperatively catalyze the aminomethylation of α,β-unsaturated aldehydes. This cooperative catalytic reaction provides a redox neutral strategy for quick access to β2-amino esters in an enantioselective manner.
(photo via AlexanderBlum)
And it’s not that I don’t share the book’s values, either. Like most people, I prefer local humanely raised pork to the feedlot variety. If you haven’t yet, I hope you get a chance to try freshly dug potatoes from a farmers market in a month or two, so you too can be amazed by the depth of flavor atypical of the grocery store variety. I recently bought Anson Mills polenta and grits for the first time, and I’m converted. They’re incredible. They’re fantastically expensive too, as carefully grown food, the best in its class, often is. My grandmother would roll over in her grave if she knew I had used two cups of them just to dredge buttermilk-soaked pork chops (you know, among other concerns there), as the cookbook suggests. I unquestionably believe the world would be a better place if we all had access and the budget for these kinds of ingredients, or if we could all eat Brock’s amazing cooking — James Beard award-winning food that is exclusively indigenous to the South, using heirloom produce and heritage animal breeds — every night. But when it crosses the threshold of my apartment, it’s hard not to be aggressively aware of its gap with the reality I live in, or, as Morrissey once sung to me from a poster on my high school bedroom wall, “it says nothing to me about my life.”