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Due to complications with a mechanical heart pump, surgeons in New York removed a pig kidney from Lisa Pisano less than two months after transplanting it. The genetically engineered pig kidney did not show signs of rejection but suffered from inadequate blood flow. Wired reports: Pisano was facing heart and kidney failure and required routine dialysis. She wasn't eligible to receive a traditional heart and kidney transplant from a human donor because of several chronic medical conditions that reduced the likelihood of a good outcome. Pisano first received a heart pump at NYU Langone Health on April 4, followed by the pig kidney transplant on April 12. The heart pump, a device called a left ventricular assist device or LVAD, is used in patients who are either awaiting heart transplantation or otherwise aren't a candidate for a heart transplant. In a statement provided to WIRED, Pisano's medical team explained that they electively removed the pig kidney on May 29-47 days after transplant -- after several episodes of the heart pump not being able to pass enough blood through the transplanted kidney. Steady blood flow is important so that the kidney can produce urine and filter waste. Without it, Pisano's kidney function began to decline. "On balance, the kidney was no longer contributing enough to justify continuing the immunosuppression regimen," said Robert Montgomery, director of the NYU Langone Transplant Institute, in the statement. Like traditional transplant patients, Pisano needed to take immunosuppressive drugs to prevent her immune system from rejecting the donor organ. The kidney came from a pig genetically engineered by Virginia biotech company Revivicor to lack a gene responsible for the production of a sugar known as alpha-gal. In previous studies at NYU Langone, researchers found that removing this sugar prevented immediate rejection of the organ when transplanted into brain-dead patients. During Pisano's surgery, the donor pig's thymus gland, which is responsible for "educating" the immune system, was also transplanted to reduce the likelihood of rejection. A recent biopsy did not show signs of rejection, but Pisano's kidney was injured due to a lack of blood flow, according to the statement. The team plans to study the explanted pig kidney to learn more.

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Over two and a half years after Microsoft said it'd one day kill to-do service Wunderlist in favor of its own To Do app, it has revealed when it'll drop the ax: May 6th. From a report: After that time, Wunderlist's to-do lists won't sync anymore and you'll have a limited time to export lists from there into To Do. As of today, Microsoft won't accept any more sign-ups for Wunderlist. Microsoft bought Wunderlist creator 6Wunderkinder in 2015 and announced To Do (or To-Do, as it was known then) in April 2017. It launched a redesigned version of To Do in September, which brought the service closer in line with Wunderlist's feature set while deepening its integration with several Microsoft services, including Outlook, Microsoft Planner and Cortana. Further reading: Wunderlist Founder Wants To Buy His App Back.

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The Villages in Florida -- home to 125,000 residents, over 54,000 homes, 32 square miles, 750 miles of road, and three distinct downtowns -- will soon get a fleet of robot taxis. "Voyage, a startup that has been operating a handful of self-driving cars in the San Jose, California-based retirement community also called The Villages, announced today that later this year it will expand to the much-larger Villages north of Orlando," reports The Verge. "This is thanks to a successful Series A fundraising round that raked in $20 million in 2017." From the report: It's an indication that, strangely enough, many of the first people to fully experience the possibilities presented by self-driving cars will be over the age of 55. Most experts agree that robot cars will first roll out as fleets of self-driving taxis in controlled environments -- college campuses, business parks, dedicated freeway lanes, city centers, or retirement communities. Self-driving startups get to boast about providing a real service for people in need, while seniors get to lord over their grandchildren about being early adopters of a bold new technology. They're also getting something a little more valuable: Voyage is giving the owners of The Villages and the smaller San Jose development equity stakes of 0.3% and 0.2%, respectively, according to The Information. Voyage's self-driving cars aren't fully driverless. Safety drivers will remain behind the wheel just in case there's a need to intervene. And to compliment its digital mapping capabilities, the startup says it will partner with Carmera, a 3D mapmaker for autonomous vehicles. This type of partnership is necessary for what Voyage believes is "the largest deployment (by area size) of self-driving cars in the world."

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theodp writes: The Education Revolution will be patented. USPTO records show that Khan Academy is seeking a patent for Systems and Methods for Split Testing Educational Videos. From the patent application: "Systems and methods are provided for comparing different videos pertaining to a topic. Two different versions of an educational video may be compared using split comparison testing. A set of questions may be provided along with each video about the topic taught in the video. Users may view one of the videos and answer the questions. Data about the user responses may be aggregated and used to determine which video more effectively conveys information to the viewer based on the question responses." Now it's up to the USPTO to decide if something like the test and control studies conducted 40+ years ago (pdf) by the PLATO system to measure the effectiveness of different teaching methods would count as prior art. In response to an earlier post on Khan Academy's pending patents on learning computer programming and 'social programming,' Slashdot user Khan Academy said that the nonprofit is using patents for good, so not to worry.

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bledri writes: After 20 years as Cisco's CEO, John Chambers will step down this summer. The search for a replacement took a committee 16 months, and they selected Chuck Robbins, who was previously responsible for the company's global sales and partner team. From the article: "Wall Street analysts said a change was expected and could signal a refocusing of Cisco, which acquired dozens of companies under Chambers but has failed to make great headway outside its core networking business."

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