Jordan McCone

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04 May 06:58

[ASAP] How to Develop Organometallic Catalytic Reactions in the Pharmaceutical Industry

by Vittorio Farina

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Organic Process Research & Development
DOI: 10.1021/acs.oprd.3c00086
13 Mar 13:34

[ASAP] Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes

by Phillip S. Grant, Ricardo Meyrelles, Oliver Gajsek, Gerhard Niederacher, Boris Maryasin, and Nuno Maulide

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Journal of the American Chemical Society
DOI: 10.1021/jacs.2c13116
21 Nov 10:21

[ASAP] Open Binding Pose Metadynamics: An Effective Approach for the Ranking of Protein–Ligand Binding Poses

by Dominykas Lukauskis, Marley L. Samways, Simone Aureli, Benjamin P. Cossins, Richard D. Taylor, and Francesco Luigi Gervasio

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Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.2c01142
31 Aug 22:33

[ASAP] A Ring ExpansionStereoselective Cycloaddition of Carbohydrate-Derived Donor–Acceptor Cyclopropanes: Synthesis of Bridged Oxepanone–Indole Hybrids

by M V Kamala Lakshmi, Intzar Ali, and Ramu Sridhar Perali

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.2c01652
21 Jul 00:31

[ASAP] Synthetic Approaches to the New Drugs Approved During 2020

by Andrew C. Flick, Carolyn A. Leverett, Hong X. Ding, Emma L. McInturff, Sarah J. Fink, Subham Mahapatra, Daniel W. Carney, Erick A. Lindsey, Jacob C. DeForest, Scott P. France, Simon Berritt, Simone V. Bigi-Botterill, Tony S. Gibson, Rebecca B. Watson, Yiyang Liu, and Christopher J. O’Donnell

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.2c00710
15 Jul 05:07

[ASAP] Addition Reaction of Alcohol to Isocyanate Catalyzed by Copper Present in Tap Water: Robust Manufacturing Process of Naldemedine Tosylate

by Shinichi Oda, Yoshiyuki Masui, Sohei Omura, Yoshiaki Imamura, Yoshiyuki Takeuchi, and Masahiro Hosoya

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Organic Process Research & Development
DOI: 10.1021/acs.oprd.2c00187
12 Jul 23:16

[ASAP] Tongalides, Halogenated Butenolides from an Antarctic Delisea sp. Rhodophyte

by Joe Bracegirdle, Sarah J. Kennedy, Chuan Shan, Lukasz Wojtas, Lindsey N. Shaw, Charles D. Amsler, James B. McClintock, and Bill J. Baker

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Journal of Natural Products
DOI: 10.1021/acs.jnatprod.2c00344
11 Jul 21:33

[ASAP] Synthesis of MDM2-p53 Inhibitor BI-0282 via a Dipolar Cycloaddition and Late-Stage Davis–Beirut Reaction

by Juergen Ramharter, Michael Kulhanek, Maike Dettling, Gerhard Gmaschitz, Jale Karolyi-Oezguer, Harald Weinstabl, and Andreas Gollner

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Organic Process Research & Development
DOI: 10.1021/acs.oprd.2c00192
04 Jul 03:11

[ASAP] SN2 versus SN2′ Competition

by Thomas Hansen, Pascal Vermeeren, Lea de Jong, F. Matthias Bickelhaupt, and Trevor A. Hamlin

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.2c00527
15 Jun 05:10

[ASAP] The Ukrainian Factor in Early-Stage Drug Discovery in the Context of Russian Invasion: The Case of Enamine Ltd

by Ivan S. Kondratov, Yurii S. Moroz, Oleksandr O. Grygorenko, and Andrey A. Tolmachev

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ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.2c00211
15 May 21:53

[ASAP] pH-Dependent Conformational Switching of Amide Bondsfrom Full trans to Full cis and Vice Versa

by Ryan Thurston, Viviane Zantop, Kristen Sodam Park, Harald Maid, Anke Seitz, and Markus R. Heinrich

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Organic Letters
DOI: 10.1021/acs.orglett.2c00938
03 May 03:19

[ASAP] Aryl Boronic Esters Are Stable on Silica Gel and Reactive under Suzuki–Miyaura Coupling Conditions

by Naoki Oka, Tsuyoshi Yamada, Hironao Sajiki, Shuji Akai, and Takashi Ikawa

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Organic Letters
DOI: 10.1021/acs.orglett.2c01174
20 Apr 20:36

[ASAP] Intramolecular, Visible-Light-Mediated Aza Paternò-Büchi Reactions of Unactivated Alkenes

by Dominique E. Blackmun, Stephen A. Chamness, and Corinna S. Schindler

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Organic Letters
DOI: 10.1021/acs.orglett.2c01008
30 Sep 07:15

[ASAP] AlphaFold 2: Why It Works and Its Implications for Understanding the Relationships of Protein Sequence, Structure, and Function

by Jeffrey Skolnick, Mu Gao, Hongyi Zhou, and Suresh Singh
Jordan McCone

cool

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Journal of Chemical Information and Modeling
DOI: 10.1021/acs.jcim.1c01114
10 Mar 02:24

[ASAP] Bioinspired Synthesis of the Furopyrazine Alkaloid Hyrtioseragamine A

by Shi-Wei Kim, Paul A. Hume, and Jonathan Sperry

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The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.1c00174
07 Mar 03:40

ent-Atisane diterpenoids: isolation, structure and bioactivity

Nat. Prod. Rep., 2021, 38,330-345
DOI: 10.1039/D0NP00039F, Review Article
Grace J. Drummond, Phillip S. Grant, Margaret A. Brimble
This review provides a comprehensive summary of the literature relating to ent-atisane diterpenoids spanning the 50 years following their initial discovery.
The content of this RSS Feed (c) The Royal Society of Chemistry
21 Jan 21:47

[ASAP] Structure- and Similarity-Based Survey of Allosteric Kinase Inhibitors, Activators, and Closely Related Compounds

by Oliver Laufkötter, Huabin Hu, Filip Miljković, and Jürgen Bajorath

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Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.0c02076
25 Nov 07:06

[ASAP] Total Synthesis and Bioactivity Studies of Fungal Metabolite (−)-TAN-2483B

by Jordan A. J. McCone, Kalpani K. Somarathne, Christopher L. Orme, Russell J. Hewitt, Elysha-Rose Grant, Kelsi R. Hall, David F. Ackerley, Anne C. La Flamme, and Joanne E. Harvey

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Organic Letters
DOI: 10.1021/acs.orglett.0c03303