gunnar.werncke

Nature Communications, Published online: 26 December 2022; doi:10.1038/s41467-022-35536-3

Neuronal organoids derived from human induced pluripotent stem cells can be transplanted and integrated into the rodent cortex for the study of brain development and function. Here the authors demonstrate use of transparent graphene microelectrodes and two photon imaging for longitudinal, multimodal monitoring of functional connectivity between human iPSC derived neuronal organoids and the mouse cortex.

EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES A mesoscale convective system in South Dakota. Soil moisture and summer rainfall in central United States Interactions between soil moisture and precipitation play a major role in the central United States, where mesoscale convective systems (MCS) spanning over 100 kilometers account for 30–70% of warm-season...

Did the Caribbean sweep into the western Amazon millions of years ago, shaping the region’s rich biodiversity? A tropical shrub called Chrysobalanus icaco pushes up through Brazil’s white sandy beaches. The plant’s leathery oval leaves and tough silver bark give it the distinct appearance of a mangrove species, adapted to...

Nature Communications, Published online: 18 November 2020; doi:10.1038/s41467-020-19757-y

Large volumes of true random numbers are needed for increasing requirements of secure data encryption. Here the authors use the stochastic nature of DNA synthesis to obtain millions of gigabytes of unbiased randomness.

Nature Communications, Published online: 10 September 2020; doi:10.1038/s41467-020-18568-5

Author Correction: Requirements for the differentiation of innate T-bet^high memory-phenotype CD4⁺ T lymphocytes under steady state

Resolution limit of image analysis algorithms

Resolution limit of image analysis algorithms, Published online: 15 February 2019; doi:10.1038/s41467-019-08689-x

The resolution limitations when using the ubiquitous algorithms that process images obtained using modern techniques are not straightforward to define. Here, the authors examine the performance of localization algorithms and use spatial statistics to provide a metric for assessing the resolution limit of such algorithms.

Reduction of neutral metal clusters (Co₄(CO)₁₂, Ru₃(CO)₁₂, Fe₃(CO)₁₂, Ir₄(CO)₁₂, Rh₆(CO)₁₆, {CpMo(CO)₃}₂, {Mn(CO)₅}₂) by decamethylchromocene (Cp*₂Cr) or sodium fluorenone ketyl in the presence of cryptand[2.2.2] and DB‐18‐crown‐6 was studied. Nine new salts with paramagnetic Cp*₂Cr⁺, cryptand[2.2.2](Na⁺), and DB‐18‐crown‐6(Na⁺) cations and [Co₆(CO)₁₅]^2– (1, 2), [Ru₆(CO)₁₈]^2– (3–4) dianions, [Rh₁₁(CO)₂₃]^3– (6) trianions, and new [Ir₈(CO)₁₈]^2– (5) dianions were obtained and structurally characterized. The increase of nuclearity of clusters under reduction was shown. Fe₃(CO)₁₂ preserves the Fe₃ core under reduction forming the [Fe₃(CO)₁₁]^2– dianions in 7. The [CpMo(CO)₃]₂ and [Mn(CO)₅]₂ dimers dissociate under reduction forming mononuclear [CpMo(CO)₃]^– (8) and [Mn(CO)₅]^– (9) anions. In all anions the increase of negative charge on metal atoms shifts the bands attributed to carbonyl C–O stretching vibrations to smaller wavenumbers in agreement with the elongation of the C–O bonds in 1–9. In contrast, the M–C(CO) bonds are noticeably shortened at the reduction. Magnetic susceptibility of the salts with Cp*₂Cr⁺ is defined by high spin Cp*₂Cr⁺ (S = 3/2) species, whereas all obtained anionic metal clusters and mononuclear anions are diamagnetic. Rather weak magnetic coupling between S = 3/2 spins is observed with Weiss temperature from –1 to –11 K. That is explained by rather long distances between Cp*₂Cr⁺ and the absence of effective π–π interaction between them except compound 7 showing the largest Weiss temperature of –11 K. The {DB‐18‐crown‐6(Na⁺)}₂[Co₆(CO)₁₅]^2– units in 2 are organized in infinite 1D chains through the coordination of carbonyl groups of the Co₆ clusters to the Na⁺ ions and π–π stacking between benzo groups of the DB‐18‐crown‐6(Na⁺) cations.

Chemistry – A European Journal, EarlyView.

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia

Genome-wide association study identifies susceptibility loci for B-cell childhood acute lymphoblastic leukemia, Published online: 09 April 2018; doi:10.1038/s41467-018-03178-z

While GWAS have uncovered susceptibility loci for B-cell precursor acute lymphoblastic leukemia (BCP-ALL), much of the heritable risk remains undiscovered. Here, the authors perform a meta-analysis of two existing BCP-ALL GWAS together with an unpublished GWAS to identify risk loci at 8q24.21 and 2q22.3.

Publication date: 1 October 2017
Source:Journal of Organometallic Chemistry, Volume 846
Author(s): Petr Štěpnička, Martin Zábranský, Ivana Císařová
Two phosphinoferrocene carboxylic acids differing in the two-carbon spacer separating the phosphinoferrocene moiety and the carboxyl group, Ph2PfcCH=CHCO2H (1a) and Ph2PfcCH2CH2CO2H (1b; fc = ferrocene-1,1′-diyl), were prepared from aldehyde Ph2PfcCHO by Horner-Wadsworth-Emmons olefination, reduction and hydrolysis. These acids reacted with [(L^NC)Pd(acac)] (L^NC = 2-[(dimethylamino-κN)methyl]phenyl-κC ¹, acac = pentane-2,5-dionate) under protonation and elimination of the Pd-bound acetylacetonate ligand to afford the respective phosphinocarboxylate complexes, namely, the P,O-bridged dimer [(L^NC)Pd{μ(P,O)-Ph2PfcCH=CHCO2}]2 (6a) and the coordination polymer [(L^NC)Pd{μ(P,O)-Ph2PfcCH2CH2CO2}] n (6a). The crystal structures of P-sulfides prepared from acids 1a and 1b, compounds Ph2P(S)fcCH=CH2CO2H and Ph2P(S)fcCH2CH2CO2H, and the phosphinocarboxylate complexes 6a and 6b (in solvated form) were determined by single-crystal X-ray diffraction analysis.

Graphical abstract

Abstract