Nicolas Probst

Shared posts

23 Aug 13:29

[ASAP] Nickel-Catalyzed Arylation of C(sp3)–O Bonds in Allylic Alkyl Ethers with Organoboron Compounds

by Xiaowei Li, Yuxiu Li, Zhong Zhang, Xiaolin Shi, Ruihua Liu, Zemin Wang, Xiangqian Li, and Dayong Shi

TOC Graphic

Organic Letters
DOI: 10.1021/acs.orglett.1c01879
15 Jul 14:58

Berthold Hoge

Berthold Hoge

“My favorite saying is ‘diamonds are created under pressure’. … My first experiment was to blow up a tin can using a mixture of sugar and saltpeter . …” Find out more about Berthold Hoge in his Author Profile.


29 Jun 13:03

[ASAP] Citrofulvicin, an Antiosteoporotic Polyketide from Penicillium velutinum

by Yong Chen, Nan Jiang, Ying Jie Wei, Xiang Li, Hui Ming Ge, Rui Hua Jiao, Ren Xiang Tan

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Organic Letters
DOI: 10.1021/acs.orglett.8b01272
12 Jan 11:53

Hydrodehalogenation of Haloarenes by a Sodium Hydride–Iodide Composite

by Derek Yiren Ong, Ciputra Tejo, Kai Xu, Hajime Hirao, Shunsuke Chiba

Abstract

A simple protocol for hydrodebromination and -deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies showed that an unusual concerted nucleophilic aromatic substitution operates in the present process.

Thumbnail image of graphical abstract

A simple protocol for hydrodebromination and -deiodination of halo(hetero)arenes was enabled by sodium hydride (NaH) in the presence of lithium iodide (LiI). Mechanistic studies show that an unusual concerted nucleophilic aromatic substitution operates in the present process.

02 Nov 07:28

Direct assembly of multiply oxygenated carbon chains by decarbonylative radical–radical coupling reactions

by Kengo Masuda

Nature Chemistry. doi:10.1038/nchem.2639

Authors: Kengo Masuda, Masanori Nagatomo & Masayuki Inoue

Pentoses and hexoses represent important structural motifs in bioactive secondary metabolites, though their synthesis often requires several elongation steps. Now, a method for radical–radical coupling reactions of sugar derivatives enables the single-step preparation of the oxygenated carbon chains of several natural products, including sagittamide D, maitotoxin and hikizimycin.

25 Apr 13:41

Sequence-Specific 2-Cyanobenzothiazole Ligation

by Carlo P. Ramil, Peng An, Zhipeng Yu and Qing Lin

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Journal of the American Chemical Society
DOI: 10.1021/jacs.6b00982