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21 Jul 10:04

A highly enantioselective Mannich reaction of aldehydes with cyclic N-acyliminium ions by synergistic catalysis

Chem. Commun., 2015, 51,13694-13697
DOI: 10.1039/C5CC04416B, Communication
Francesco Berti, Federico Malossi, Fabio Marchetti, Mauro Pineschi
A novel enantioselective synthesis of carbamoyl isoquinoline and tetrahydropyridine derivatives is accomplished using matched combinations of Lewis or Bronsted acids and secondary amine organocatalysts.
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