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27 Jan 03:28

The caste system has left its mark on Indians’ genomes

by Annalee Newitz

Lord Parshuram with Brahmin settlers commanding Lord Varuna to make the seas recede and allow Brahmins to make their homes in Kerala. (credit: Drshenoy)

Over 1,500 years ago, the Gupta emperors ruled large parts of India. They helped consolidate the nation, but they also popularized India's caste system, making it socially unacceptable for people to marry outside their castes. Now, a new analysis of genetic variation among contemporary Indians has revealed that this social shift left a distinctive genetic signature behind.

A group of researchers in India conducted this analysis by comparing the genomes of hundreds of Indians from throughout the country. As they write in a paper published today in Proceedings of the National Academy of Science, samples came from "367 unrelated individuals drawn from 18 mainland and two island (Andaman and Nicobar Islands) populations selected to represent geographic, linguistic, and ethnic diversities." Previous studies had suggested that today's Indians came from two ancestral populations, but the new analysis revealed four distinct "haplotypes," or bundles of genetic elements that travel through generations in a package. People with the same haplotypes likely came from the same ancestral groups. The researchers also found a fifth haplotype among people of the Andaman archipelago.

Careful examination of the variations between these haplotypes, compared with haplotypes of other people throughout the world, revealed that India's ancient populations probably came first from Africa. Later waves of settlement came from people who shared genetic similarities with populations in South Central Asia and East Asia. These groups remained genetically distinct, and the linguistic history of India suggests they spoke languages with dramatically different origins. Nevertheless, it appears there was a good deal of intermarriage, which shows up in genomes of people who possess genetic sequences typical of two or more haplotypes.

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15 Jan 17:20

Saturday Morning Breakfast Cereal - Understanding

by admin@smbc-comics.com

Hovertext: Anyway, goodbye. I have to let another sentient species know how pointless it all is.


New comic!
Today's News:

Only a few dozen dicounted "both shows" tickets remain. Please buy to save enough for an okay beer after the show! 

03 Jan 19:28

Sex and the Muslim Feminist

by Robin Varghese

Df805d5f9dfef29735246cf202c9cff4a0dd4922

Rafia Zakaria in The New Republic:

Being Muslim and female was an identity that rhymed effortlessly with repression and oppression in the view of most liberal academics and students. I had heard it all so often and in so many other classes: the interdiction of the hapless women who were imprisoned by Islam, as an offhand way to highlight the relative fortune of the more successful Western feminist, the one that had moved from questions of basic equality to concerns with sexual pleasure. No texts by Muslim feminists were assigned reading for the course: not Leila Ahmed’s Women and Gender in Islam and not Amina Wadud’s Qu’ran and Woman. The course’s sole concession to diversity a single slim text—Borderlands/La Frontera: The New Mestiza—by the Chicana feminist Gloria Anzaldua.

That curriculum was chosen nearly a decade ago, but the exclusion of Muslim feminists has continued. In an interview published in the New York Times last week, feminist icon Gloria Steinem, whose latest memoir was published last month, namedtwenty-eight women and three men in her list of “best contemporary feminist writers.” She fails to mention a single Muslim feminist. In other instances, I’ve found my own writing on women and militancy attacked; not met with analysis and engagement, but with condescending suggestions that, because I am female and Muslim, I am somehow “excited” by the idea of a female Muslim warrior. While the tone and tenor of these may vary, the message is the same: The Muslim feminist is either left out of the conversation or included only as an example of a deviant type, demanding liberals’ suspicion and vigilance.

I realized this even then. Contesting the premises of my professor and classmates would label me the prude, the insufficiently liberated. Speaking would court encirclement by pitying, knowing glances reserved for one understood to be plagued by yet un-confronted repressions. If I spoke, I would give them what they wanted: a Muslim woman to save, to school in the possibilities of sexual liberation. It would be impossible, in the rush and fervor of that savior encounter, to explain that my oppositions were not at all to sex or sexual pleasure, but to its construction as unproblematic, un-colonized by patriarchy, the entire measure of liberation.

More here.

03 Jan 18:28

You won’t believe this story: Tamiflu conflict of interest

by Andrew
Austin.soplata

News to me:
1. Tamiflu may not be effective at all.
2. Even if pro-Tamiflu studies are true (contradicting the Cochran Collaboration), it's hard to parse the signal from the noise given the very-many-fronts Tamiflu owners/producers have used to monetarily influence the research process.
3. You can still get very rich (500M British pounds of UK stockpiling, close to a billion dollars!) by selling something that may be snake oil.

Evilicious-Cover

Paul Alper writes:

Maybe it is time to return to really important things such as medical swindles in particular, Tamiflu. Consider Tamifu and its financially-influenced and influential supportors as seen from the fabulous Susan Perry of Minnpost:

The group of researchers who conducted the Lancet study [supporting Tamiflu]was described in a commentary that accompanied their study as also being “independent” But is that true? No. As [Jeanne] Lenzer points out (in her BMJ article and in a later follow-up piece), all four coauthors of the Lancet meta-analysis have received speaker’s or consultancy fees, grants or contracts from either Roche, the company that makes and sells Tamiflu, or Gilead, the company that holds the patent to the drug.

And the conflicts of interest don’t end there. The listed funding source for the Lancet study — the Multiparty Group for Advice on Science (MUGAS) — received an unrestricted grant from Roche specifically to pay for the study.

It gets even murkier. MUGAS was co-founded by the managing director of a Belgium-based public relations firm, Semiotics, which receives 20 percent of its funding from Roche, according to Lenzer.
For the record: The authors of the Lancet study deny that Roche had any influence on their study’s design or its results.

And from Lenzer:

The CDC Foundation, created by Congress to “connect CDC to the private sector to advance pubic health,” provides funding to the CDC. The foundation confirmed to The BMJ that the CDC received a directed donation from Roche via the foundation for the [“Take 3”] campaign, stating, “Roche provided a grant of $198,000 to CDC Foundation [which] has an administrative fee of 13.5%, so $174,800 was provided to [the CDC to] support qualitative research into influenza prevention and treatment messaging.”

This is not the only money the CDC takes from the industry. Unbeknownst to many, the CDC receives substantial industry funding through the CDC Foundation. A spokesperson said that over the past three years the foundation has received an average of about $6.3 [million] from the industry a year, 21% of the foundation’s overall funding. Since 1995 the foundation has received funding from more than 150 corporate “partners,” including Gilead, which holds the patent on oseltamivir [Tamiflu], as well as Genentech and Roche, the drug’s manufacturers.

Neither the CDC nor the foundation provided data on how much funding Roche, Gilead, and Genentech have donated to the CDC in addition to that for the Take 3 campaign.

I can relate to this, as I’m working right now with Novartis on a couple of projects which help support the Stan project. It all seems ok to me but I can see the general potential for problems.

P.S. Alper points to this news article by Ben Goldacre, who wrote on 10 Apr 2014:

Today we found out that Tamiflu doesn’t work so well after all. Roche, the drug company behind it, withheld vital information on its clinical trials for half a decade, but the Cochrane Collaboration, a global not-for-profit organisation of 14,000 academics, finally obtained all the information. Putting the evidence together, it has found that Tamiflu has little or no impact on complications of flu infection, such as pneumonia.

That is a scandal because the UK government spent £0.5bn stockpiling this drug in the hope that it would help prevent serious side-effects from flu infection. But the bigger scandal is that Roche broke no law by withholding vital information on how well its drug works. . . .

Wow. Evilicious indeed.

The post You won’t believe this story: Tamiflu conflict of interest appeared first on Statistical Modeling, Causal Inference, and Social Science.

30 Dec 17:31

Who really pays for American students to go to college?

by Elizabeth Tandy Shermer

Individually, Americans spend a lot on higher education. Most undergraduates finish with about $30,000 in debt. It’s an average that calls into question how much voters, educators and policymakers have done to support the country’s colleges and students. Americans instead nurtured a student‑loan ...

By Elizabeth Tandy Shermer

Read at Aeon

26 Dec 03:56

“Journalistic lapses at the New York Times should, in effect, count triple”

by Andrew

apuzzo

Palko, writing about the latest Judith Miller Matt Apuzzo, Michael Schmidt, and Julia Preston story:

There is no publication in the country, perhaps even in the world, with a reputation like that of the New York Times. It is almost universally considered the standard for American newspapers. For that reason, I would argue that journalistic lapses at the New York Times should, in effect, count triple. First, there is the damage that always comes from bad journalism, second there is the additional impact of having unreliable news coming from what is considered a reliable source, and third there is the chilling effect on the standards of other publications. “If they can cut corners, why can’t we?”

Well put. When the Paper of Record repeatedly refuses to correct the errors of David Brooks, I’m annoyed, but op-eds aren’t real news. When the Wall Street Journal publishes the ignorant ravings of torture apologist John Yoo . . . well, they’re the Wall Street Journal, if they get the business news right, who cares about their editorial page. But when the Times starts blowing it on the news pages, I agree with Palko that we should be concerned.

Palko quotes Josh Marshall:

[The Times] aimed at such a general audience and seemed focused on writing the broad, definitive piece that articles were published with such a level of vagueness that there weren’t a lot of factual details to work with.

So it wasn’t that they were wrong or inaccurate necessarily – just vague and unspecific.

Except when they were totally wrong.

Interesting point, that the pressure to be definitive could create problems. Shades of PPNAS.

P.S. In the old days I would’ve posted this on the Monkey Cage but now that we’re at the Washington Post, it wouldn’t quite come across right.

P.P.S. More here from NYT Public Editor Margaret Sullivan.

The post “Journalistic lapses at the New York Times should, in effect, count triple” appeared first on Statistical Modeling, Causal Inference, and Social Science.

21 Dec 17:38

Al Jazeera Blocks Anti-Saudi Arabia Article

by Cora Currier

THE CORPORATE HEADQUARTERS of Al Jazeera appears to have blocked an article critical of Saudi Arabia’s human rights record from viewers outside the United States. The news network, which is funded by the government of Qatar, told local press that it did not intend to offend Saudi Arabia or any other state ally, and would remove the piece.

The op-ed, written by Georgetown University professor and lawyer Arjun Sethi and titled, “Saudi Arabia Uses Terrorism as an Excuse for Human Rights Abuses,” ran on the website of Al Jazeera America, the network’s U.S. outlet. It comments on reports of 50 people recently sentenced to death for alleged terrorist activity and criticizes the U.S. government’s silence on Saudi Arabia’s human rights record.

The article ran on December 3, and is still available in the United States, but people attempting to view the link in other countries were given an error or “not found” page. (For international readers, we’ve reprinted the full text of the article here.)

When asked by The Intercept about the article, Al Jazeera’s headquarters in Doha said in a statement, “After hearing from users from different locations across the world that several of our web pages were unavailable, we have begun investigating what the source of the problem may be and we hope to have it resolved shortly.” 

Last week, the Saudi Arabian newspaper Okaz quoted a director of Al Jazeera apologizing for the article and saying that it would be removed. Another news story, from a Bahraini website, shows a tweet from Al Jazeera America’s account with the article’s headline. That tweet appears to have been deleted. A spokesperson for Al Jazeera America would not comment on the tweet or on the discrepancy between the parent company’s statement to The Intercept and the comments in Okaz.

The criticisms of Saudi Arabia in Sethi’s piece are by no means unusual. He notes a steep rise in executions in Saudi Arabia this year, with Amnesty International reporting over 150 people killed, including adolescents; the sentencing of poet Ashraf Fayadh to death for “apostasy”; and allegations by international humanitarian groups that Saudi Arabian airstrikes in Yemen kill civilians indiscriminately. The reports Sethi cites have been widely covered in the media (including The Intercept.) Sethi, who has written several articles for Al Jazeera America and Al Jazeera English, the network’s international franchise, told The Intercept that Al Jazeera America had solicited the op-ed from him.

A few days after publication, Sethi’s Twitter feed was flooded with attacks from pro-Saudi accounts. David Johnson, senior opinion editor at Al Jazeera America, retweeted many of the attacks. (He declined to be interviewed for this piece.)

“The trolling seemed like an organized concerted effort to intimidate me,” Sethi said. “I will not submit to this act of censorship. Human rights are universal and I will continue to litigate and write about violations wherever they occur.”

Qatar is a monarchy tightly ruled by the emir Sheikh Tamim bin Hamad al-Thani. The tiny, oil rich country has allied with Saudi Arabia against the government of Syria in that country’s civil war, and is part of Saudi Arabia’s campaign against the Houthi rebels in Yemen, contributing to the devastating air war and deploying more than 1,000 ground troops this fall. Qatar is also part of the 34-nation Islamic alliance against terrorism that Saudi Arabia announced this week.

The Saudi Arabian embassy in Washington, D.C., did not respond to questions about whether it had discussed the article with Al Jazeera or the Qatari government.

While Al Jazeera’s international coverage has been praised — particularly in the years after the 9/11 attacks — this is not the first time that the network has appeared to cater to the interests of Qatar and its Gulf allies. (Disclosure: prior to joining The Intercept, I wrote an article for Al Jazeera America as a freelancer.)

It has been criticized for lack of coverage of protests against the government of Bahrain, for example, and in 2012, several journalists complained that they had to edit coverage of Syria to feature the emir of Qatar’s position. In 2013, staffers in Egypt resigned in protest of the network’s bias toward the Muslim Brotherhood after the military deposed the president, Mohamed Morsi. (The Egyptian government subsequently jailed three Al Jazeera journalists for alleged collaboration with the Muslim Brotherhood in a widely denounced trial. The last of the reporters were freed in September.)

Al Jazeera America was founded in 2013 as the U.S. face of the network. It has struggled to gain a large audience and was roiled by drama this year, with the departure of several top executives amid allegations of sexism and workplace dysfunction. Qatar’s emir also announced cutbacks in government support for the news network overall this year.

The apparent censorship of the Sethi article seems to be unprecedented, however. Several Al Jazeera America staffers said that they were unaware of another instance in which the parent company had blocked an article in this way.

The post Al Jazeera Blocks Anti-Saudi Arabia Article appeared first on The Intercept.

21 Dec 17:37

Tug of War: Epic battle over data in controversial paper on chronic fatigue syndrome

by Andrew
Austin.soplata

This whole saga is crazy.

Sopranos_ep211b

James Coyne wrote to me a couple weeks ago:

This time I’m critiquing a horrible mediational analysis. The larger context is that the authors have refused all requests to share data that would be needed to make an independent evaluation of their interpretation. I am now in what will be a highly visible confrontation with them because I’ve asked for related data that they published in PLOS One. PLOS One has strict data sharing policies and we are awaiting a Thursday midnight deadline for a response from their university.

He sent me a copy of the paper (Rehabilitative therapies for chronic fatigue syndrome: a secondary mediation analysis of the PACE trial, by Trudie Chalder, Kimberley Goldsmith, Peter White, Michael Sharpe, and Andrew Pickles) that he’d criticized. I glanced at the paper and his comments and wrote back to him:

Maybe it’s worth just ignoring this stuff. There’s so much bad research out there! Or is the topic itself important, and you’re concerned that the bad research will have a malign effect on policy?

Before going on, that you should not consider my above statement as a diss of the Chalder et al. paper, nor, for that matter, should you consider this disclaimer as a statement of support. I looked at the paper only very quickly, and I have a skepticism of pretty much any of these mediation models (as illustrated, for example, by figure 7 from Chalder et al.), so I responded to Coyne with a generic statement that sometimes it’s better just to ignore bad research.

Coyne replied:

I agree it’s an absolute disaster of a paper. It otherwise should not be the object of my attention but there is some nastiness associated with its dissemination. Peter White, one of the authors is paid for working with a group trying to get social welfare payments denied to people with chronic physical illness. He promotes the idea that chronic fatigue syndrome, whatever its origins, is perpetuated by fears of exertion. The deconditioning model that is the basis for these claims has been discredited. So he is forced to rely on dodgy research like this to promote the view that chronic fatigue syndrome is largely “cognitive” and psychosomatic. I’ve seen horrible testimony from him that patients who “appear” to be disabled should be denied handicap parking passes because that will force them to walk more. He has personally testified in a number of hearings where patients with chronic fatigue syndrome have had the benefits revoked.

The Institute of Medicine has recently released an extensive report that takes issue with conceptualization of chronic fatigue syndrome as psychosomatic. It explores a number of physiological bases for what is a very heterogeneous group of conditions. Most importantly, while the report indicates that fatigue is a common symptom, the disabilities are much more extensive and subjective fatigue is not a suitable primary outcome for evaluating interventions.

Here is my [Coyne’s] blogging about a more recent paper from this group.

And then more:

We have come under pressure from a number of sources, including Richard Horton, editor of the Lancet [the journal where the Chalder et al. paper appeared]. Comments on my blog posts were temporarily closed at PLOS’s’ Mind the Brain last Monday. Although I am still blogging there, I have moved my advocacy for releasing the the data from a cost analysis of the PACE trial published in PLOS One to my own blog, Quick Thoughts. This was done to decrease the pressure on PLOS and to ensure there was no appearance of a conflict of interest in my using their blog site. I am not involved in the decision-making at the journal concerning the release of the data and anyone can make a similar request.

But now, Retraction Watch, Dorothy Bishop, and even Richard Smith, former editor of BMJ, have joined me in calling for the release of the PLOS data. PLOS is in contact with lawyers.

Although there is a remarkable lack of transparency and basic data being presented, enough issues can be raised about claims the PACE investigators have made in their articles and to the press. An independent look at the data is needed.

So, this is emerging as a major, maybe historic confrontation between the forces pushing for sharing of data and the British establishment. I think I am going to get the data, but the task remains of degrading this ridiculous mediational analysis paper which is used to deny benefits to patients with chronic fatigue syndrome. One of the authors, Peter White, was testifying before a British government toward to get the handicap parking passes of persons with chronic fatigue, before the data were even analyze. Furthermore, primary outcomes were changed after patients started new crew. It’s an incredible mess.

I haven’t looked into any of this in detail but I’m posting the story here because it illustrates the connections between disputed research claims and policy. Never-back-down, never-admit-error attitudes can have consequences.

The post Tug of War: Epic battle over data in controversial paper on chronic fatigue syndrome appeared first on Statistical Modeling, Causal Inference, and Social Science.

21 Dec 17:23

Blackberry CEO says Apple has gone to a “dark place” with pro-privacy stance

by David Kravets
Austin.soplata

The layers of irony here astound. Especially since their new flagship, the "Priv", is literally named after privacy! And "our privacy commitment does not extend to criminals" Um, whose definition of criminals? If I, as a US businessperson, blaspheme on my corporate phone in Saudi Arabia, which state am I a criminal of? (poor example, but still)

Blackberry Priv (credit: Ron Amadeo)

John Chen, the Blackberry chairman and CEO, is ripping Apple's position that granting the authorities access to a suspected criminal's mobile device would "tarnish" the iPhone maker's image.

"We are indeed in a dark place when companies put their reputations above the greater good. At BlackBerry, we understand, arguably more than any other large tech company, the importance of our privacy commitment to product success and brand value: privacy and security form the crux of everything we do. However, our privacy commitment does not extend to criminals," Chen wrote in a blog post titled "The encryption Debate: a Way Forward."

Chen links to a recent Ars story in which Apple is fighting the authorities on whether it should give them access to an iPhone running iOS 7. Among other things, Apple argues in the criminal case that "forcing Apple to extract data in this case, absent clear legal authority to do so, could threaten the trust between Apple and its customers and substantially tarnish the Apple brand. This reputational harm could have a longer term economic impact beyond the mere cost of performing the single extraction at issue."

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20 Dec 21:09

Why Are Drug Monopolies Running Amok? Meet Deborah Feinstein

by David Dayen

One of the biggest policy debates in America today concerns the unparalleled rise in prescription drug costs. Enormous pharmaceutical industry profit margins; tales of companies like Turing, Valeant, and Gilead Sciences jacking up the price of life-saving medicines; and a spate of industry mergers (the latest being a $150 billion deal between Pfizer and Allergan, designed mostly to lower their tax rates) have lawmakers and presidential candidates scrambling for answers.

But one point has been lost among the various proposals: The U.S. has had antitrust laws on the books for over 100 years to reduce the power of monopolies and restrain consumer costs. They could come in handy in situations like these.

Bernie Sanders recognized this when he urged the Obama administration to block the Pfizer-Allergan merger. Hillary Clinton has promised to “stop corporate concentration” in the pharmaceutical industry.

The problem is that the federal agency responsible for antitrust oversight of drug companies — the Federal Trade Commission — has a terrible track record of supporting the public interest.

feinstein_debbie-FTC

Deborah Feinstein

Photo: Federal Trade Commission

And the reason why can be seen in the career trajectory of one woman: Deborah Feinstein, director of the FTC’s Bureau of Competition, the agency’s main enforcement entity. During Feinstein’s tenure, the FTC has largely abandoned its attempts to block mergers, instead favoring consent agreements that have a history of failing to achieve their goals.

Feinstein has gone back and forth through the so-called revolving door. From 1989 to 1991, she worked at the FTC as an assistant director in the Bureau of Competition. In 1995, she moved to high-powered corporate law firm Arnold & Porter, becoming a partner and the head of the firm’s antitrust practice. Feinstein “specialized in representing clients before the FTC and Department of Justice,” including General Electric, NBC Universal, Unilever, and Pepsi.

On its website, Arnold & Porter brags about its robust practice in helping pharmaceutical and medical device companies “respond to complex regulatory and compliance changes.”

In 2013, Feinstein returned to the FTC to run the Bureau of Competition, while reportedly speaking fondly about how her private practice experience informed her decisions.

Arnold & Porter’s antitrust group, in fact, has a pipeline into government service. Lawyers from the group have become chair of the FTC, general counsel of the FTC, director of the FTC’s Bureau of Competition, and head of the Justice Department’s Antitrust Division. The current Antitrust Division chief, William Baer, had two stints at the FTC in between his tenure at Arnold & Porter. Robert Pitofsky, former chair of the FTC, also went back and forth between the agency and Arnold & Porter. And it’s an open secret that Feinstein will return to Arnold & Porter again after her stint is up.

“The elite D.C. antitrust bar is a small, chummy circle whose members spend most, if not all of their time representing corporations,” said Jeff Hauser, who runs the Revolving Door Project at the Center for Effective Government. “Law firms eagerly market their attorneys’ government experience, signaling to clients that their team possesses relationships with current regulators.”

Two federal agencies handle antitrust enforcement: the FTC’s Bureau of Competition and the Department of Justice’s Antitrust Division. They informally split up industries to cover, and the FTC has responsibility over several health care-related industries, including pharmaceuticals, medical devices, and consumer health products. Those happen to be among the fastest-consolidating industries in America.

Earlier this month, the FTC let Dyax’s $6 billion acquisition by Shire Pharmaceuticals go through, choosing to take no action before the antitrust waiting period lapsed. Even Wall Street expected a challenge; when it didn’t transpire, Dyax’s stock jumped 13 percent.

It was the latest in a rush of mergers and acquisitions in the industry. There were $221 billion in pharma mergers in just the first half of 2015, even more than the $162 billion for the entire previous year.

And consider what these giant companies do: Valeant Pharmaceuticals has acquired, licensed, or agreed to co-promote over 140 drugs since 2008, and as part of its strategy it buys the rights to rival drugs and increases the prices overnight by as much as 525 percent.

Horizon, another drugmaker, sells a medication called Duexis, which costs $1,500 a month, even though its component drugs cost no more than $40 a month. In 2013, Horizon acquired Deuxis’ main competitor, called Vimovo, and raised the price 600 percent.

Questcor performed the same trick by buying the main rival to its immune-deficiency drug. The FTC never challenged any of these purchase agreements.

Efforts to reach Feinstein or get a comment from the FTC were unsuccessful. But Feinstein laid out her philosophy in a speech early in her tenure. “In my view … consent orders are as effective in maintaining or restoring competition as going to court,” she said.

She argued that settlements — where the FTC allows the merger to go forward, but with certain conditions — produce faster, smarter resolutions using fewer resources, and are “a remedy that is as good as or better than what could be achieved from litigation.”

This open preference for settlements over admittedly riskier legal challenges comes directly from a career in private practice, where settlements are the end goal. But well-designed studies and recent history show that settlements don’t work.

For example, some settlements result in “conduct remedies” — like adding firewalls between parts of a business, ensuring access by competitors, or other arrangements to preserve competition. But retrospective research of conduct remedies by Northeastern University law professor John Kwoka found them uniquely ineffective in preventing harm to consumers.

Prices rose over double the normal post-merger rate when a conduct remedy was imposed. “I’ve been fairly critical of the inclination to go that route,” Kwoka said. Feinstein has explicitly dismissed Kwoka’s research.

Feinstein has also led an effort to use divestitures to try to rebuild competition. In this case, a merger can go through provided that a certain percentage of the business is sold off to create a new competitor.

Two recent examples have ended badly.

The FTC forced Hertz, as a condition for its merger with Dollar Thrifty, to spin off its Advantage Rent a Car brand. Just four months after the deal, Advantage filed for bankruptcy.

The same thing happened to the Haggen grocery chain. As part of the Albertsons merger with Safeway, the FTC required Albertsons to sell 168 stores to competitors. Haggen bought most of them, but lasted only nine months before bankruptcy, unable to bulk up from running 18 stores to 164. Ironically, while liquidating its holdings in the bankruptcy, Haggen sold 33 Oregon stores back to Albertsons, at a fraction of their sales price.

“I’m increasingly critical of divestitures to create a competitor,” said Kwoka. “It seems to be a stretch, and clearly the FTC has gotten their fingers burned.”

Feinstein defended both divestiture disasters after the fact. She insisted that the FTC did its due diligence before Albertsons sold off stores to Haggen. “We’re aware of the concerns about whether Haggen was prepared to take over these stores, but we can’t comment at this time,” Feinstein told a local California business journal.

She has also altered the FTC’s antitrust decision-making process to give herself more power. The FTC’s five commissioners ultimately decide whether to challenge a merger, after seeking recommendations from the Bureau of Competition. But Feinstein makes recommendations to the commission separately from her staff. This leads to situations where the staff wants to be more aggressive, but Feinstein prefers a settlement. Given her stature as an authority figure, Feinstein often wins out.

Feinstein reportedly overruled her staff on the Reynolds/Lorillard tobacco company merger, which the FTC cleared after a divestiture of some brands to a third party. The trade publication Capitol Forum has also cited mergers between Nielsen and Arbitron, as well as Zillow and Trulia, where Feinstein disagreed with staff and her position won out.

The FTC did block a merger between food-service companies Sysco and U.S. Foods, but Feinstein reportedly sought a settlement deal there first.

The commission has been somewhat more aggressive in challenging a spate of recent hospital mergers (at least 95 hospitals have merged each year from 2012 to 2014), but Feinstein had to recuse herself from the most recent challenged merger, of two hospitals in West Virginia.

The FTC has even taken sides with mega-conglomerates like CVS and Wal-Mart against independent pharmacies. The huge pharmacy companies sign deals with pharmacy benefit managers, or PBMs — the middlemen who administer prescription drug programs — to access “preferred pharmacy networks.” Such networks give consumers lower prices if they use certain pharmacies — and the pharmacies give the PBMs a kickback in exchange for use of the network.

States have tried to break this scheme by letting independent pharmacies form their own networks. But the FTC has routinely warned against such proposals, saying they would “impair the ability of prescription drug plans to negotiate the best prices with pharmacies.”

This furthers consolidation, both among pharmacies and PBMs. After CVS Health merged with Omnicare and OptumRx combined with its rival Catamaran — both without FTC resistance — the top three PBMs now handle 75 percent of all U.S. prescriptions.

Intervening on behalf of monopolists is the opposite of the FTC’s ostensible mission. But that’s what comes of installing people in high-level positions just because of their litigation expertise — rather than their support for strong enforcement.

“Senior antitrust positions should more often come from backgrounds other than the corporate bar,” said Hauser, of the Revolving Door Project.

He suggests selecting more candidates from academia or from the career regulatory staff.

“People with those types of backgrounds all tend to have much greater distance from, and fewer entanglements with, the corporations whose behavior they are tasked with regulating.”

The post Why Are Drug Monopolies Running Amok? Meet Deborah Feinstein appeared first on The Intercept.

15 Dec 22:06

Seattle Will Allow Uber and Lyft Drivers to Form Unions

by NICK WINGFIELD and MIKE ISAAC
Austin.soplata

hooray!

The city ordinance, approved unanimously, drew cheers from supporters, but is a new headache for the ride-hailing services.









01 Dec 01:09

Obama Says ‘Enough Is Enough’ After Colorado Shooting

by JONATHAN MARTIN
President Obama responded angrily Saturday to the mass shooting in Colorado Springs that took three lives, calling the country’s recurring outbreak of gun violence “not normal.”









28 Nov 03:22

Forensic Pseudoscience

by Nausicaa Renner

The Unheralded Crisis of Criminal Justice

November 16, 2015


Photograph: Flickr/53921113@N02
 

This past April, the FBI made an admission that was nothing short of catastrophic for the field of forensic science. In an unprecedented display of repentance, the Bureau announced that, for years, the hair analysis testimony it had used to investigate criminal suspects was severely and hopelessly flawed.

The Innocence Project’s M. Chris Fabricant and legal scholar Tucker Carrington classify the kind of hair analysis the FBI performs as “magic,” and it is not hard to see why. By the Bureau’s own account, its hair analysis investigations were unscientific, and the evidence presented at trial unreliable. In more than 95 percent of cases, analysts overstated their conclusions in a way that favored prosecutors. The false testimony occurred in hundreds of trials, including thirty-two death penalty cases. Not only that, but the FBI also acknowledged it had “trained hundreds of state hair examiners in annual two-week training courses,” implying that countless state convictions had also been procured using consistently defective techniques.

But questions of forensic science’s reliability go well beyond hair analysis, and the FBI’s blunders aren’t the only reason to wonder how often fantasy passes for science in courtrooms. Recent years have seen a wave of scandal, particularly in drug testing laboratories. In 2013 a Massachusetts drug lab technician pled guilty to falsifying tests affecting up to 40,000 convictions. Before that, at least nine other states had produced lab scandals. The crime lab in Detroit was so riddled with malpractice that in 2008 the city shut it down. During a 2014 trial in Delaware, a state trooper on the witness stand opened an evidence envelope from the drug lab supposedly containing sixty-four blue OxyContin pills, only to find thirteen pink blood-pressure pills. That embarrassing mishap led to a full investigation of the lab, which found evidence completely unsecured and subject to frequent tampering.

There have also been scores of individual cases in which forensic science failures have led to wrongful convictions, the deficiencies usually unearthed by the Innocence Project and similar organizations. In North Carolina, Greg Taylor was incarcerated for nearly seventeen years thanks to an analyst who testified that the blood of a murder victim was in the bed of his truck. But later investigation failed to confirm that the substance was blood, or even of human origin. Forensics experts have used “jean pattern” analysis to testify that only a certain brand of blue jeans could leave their distinctive mark on a truck, as occurred in the trial of New Yorker Steven Barnes, who spent twenty years in prison for a rape and murder he didn’t commit.

Some wrongful convictions can never be righted—for example, that of Cameron Todd Willingham, who was convicted by a Texas court of intentionally setting the fire that killed his three young daughters. After the state executed Willingham, an investigative team at the Texas Commission on Forensic Science concluded that the arson science used to convict him was worthless, and independent fire experts condemned the investigation as a travesty. But those findings came too late to do Willingham any good.

The mounting horror stories, and the extent of corruption and dysfunction, have created a moment of crisis in forensic science. But the real question is not just how serious the problems are, but whether it is even possible to fix them. There are reasons to suspect that the trouble with forensics is built into its foundation—that, indeed, forensics can never attain reliable scientific status.

• • •

Some of the basic problems of forensic science are hinted at in the term itself. The word forensics refers to the Roman forum; forensics is the “science of the forum,” oriented toward gathering evidence for legal proceedings. This makes forensics unusual among the sciences, since it serves a particular institutional objective: the prosecution of criminals. Forensic science works when prosecutions are successful and fails when they are not.

That purpose naturally gives rise to a tension between science’s aspiration to neutral, open-ended inquiry on the one side and the exigencies of prosecution on the other. Likewise, while true understanding is predicated on doubt and revision, the forum must reach a definitive result. The scientist’s tentativeness is at odds with a judicial process built on up-or-down verdicts, a point the Supreme Court has emphasized in order to justify allowing judges wide deference as the gatekeepers of evidence.

It shouldn’t be controversial to point out that forensic science is not really a science to begin with, not in the sense of disciplines such as biology and physics. Forensic science covers whatever techniques produce physical evidence for use in law. These may be derived from various actual scientific disciplines, including medicine, chemistry, psychology, and others, but they are linked less by their inherent similarity than by their usefulness during investigation and prosecution. Law enforcement agencies themselves have invented a number of the techniques, including blood-spatter and bite-mark analysis.

Law is a poor vehicle for the interpretation of scientific results.

Much forensic knowledge has thus developed by means unlike that of ordinary scientific research. Comparatively few major universities offer programs in forensic science; joint training in forensic sciences and policing is common. Forensic laboratories themselves are a disparate patchwork of public and private entities, with varying degrees of affiliation with police and prosecutors. The accountability of some subfields such as “forensic podiatry” (the study of footprints, gait, and other foot-related evidence) can be dubious, with judges taking the place of accreditation boards. In such a decentralized system, it can be difficult to keep track not only of whether forensic investigation is working well but also of how it even works in the first place.

The close association between forensics and law enforcement is particularly controversial. According to Frederic Whitehurst, a chemist and former FBI investigator, forensic scientists can “run into a sledgehammer” when they contradict prosecutors’ theories. “What we seem to know in the world of science is that there are some real problems in the world of forensic science,” Whitehurst told a reporter from the journal Nature. “We’d rather work on something cleaner.” It is easy to see why a chemist might consider forensics “unclean”; criminal investigations regularly flout scientific safeguards against bias. Analysts often know the identity of the suspect, potentially biasing results in favor of police’s suspicions. Even more concerning, some crime labs are paid not by the case but by the conviction, creating a strong incentive to produce incriminating evidence.

Whitehurst’s comments echoed a major report in 2009 by the National Academy of Sciences (NAS), which painted a damning portrait of forensic practices. “Many forensic tests—such as those used to infer the source of tool marks or bite marks—have never been exposed to stringent scientific scrutiny,” the report concluded.

One serious problem with those tests is that they allow for high levels of subjectivity. The NAS authors wrote that fingerprint analysis, for example, is “deliberately” left to human interpretation, so that “the outcome of a friction ridge analysis is not necessarily repeatable from examiner to examiner.” I saw this up close while working at the public defender’s office in New Orleans. Explaining his procedure for determining a match, a fingerprint examiner said in court that he would look at one, look at the other, and see if they match. When asked how he knew the two prints definitely matched, the examiner merely repeated himself. That very logic leads the FBI to claim fingerprint matches are “100 percent accurate.” Of course they are, if the question of a match is settled entirely by the examiner’s opinion. Without any external standard against which to check the results, the examiner can never be wrong.

The NAS faulted a number of methods for this kind of shortcoming. Tool-mark and firearm analysis, for example, suffer the same weaknesses as fingerprint evidence, in that they depend strongly on unverified individual judgment. The report ultimately reached the forceful determination:

With the exception of nuclear DNA analysis . . . no forensic method has been rigorously shown to have the capacity to consistently, and with a high degree of certainty, demonstrate a connection between evidence and a specific individual or source.

That sentence should give any honest forensic examiner some sleepless nights.

But what about DNA? The report affirms that DNA maintains its place of integrity, the pinnacle of sound forensic science. It is not hard to see why DNA has long been the gold standard, deployed to convict and to exonerate the unfortunate defendants victimized by faultier methods of identification. DNA also has the advantage of producing falsifiable results; one can actually prove an interpretation incorrect, in contrast to the somewhat postmodern, eye-of-the-beholder sciences such as tool-mark and fingerprint analysis.

Yet forensic science involves both knowledge and practice, and while the science behind DNA is far from the prosecutorial voodoo of jeans and bite marks, its analysis must be conducted within a similar institutional framework. Analysts themselves can be fallible and inept; the risk of corruption and incompetence is no less pronounced simply because the biology has been peer-reviewed.

Such risk isn’t merely theoretical. While Florida exoneree Chad Heins had DNA to thank for the overturning of his conviction, DNA was also responsible for the conviction itself, with an analyst giving faulty testimony about DNA found at the site where Heins’s sister-in-law was murdered. Josiah Sutton was wrongfully convicted after a Houston analyst identified DNA found on a rape victim as an “exact match” for Sutton, even though one in sixteen black men shared the DNA profile in question. Earlier this year in San Francisco, thousands of convictions were thrown into doubt after a DNA technician and her supervisor were found to have failed a proficiency exam. In preparing evidence for a trial, the two had also covered up missing data and lied about the completeness of a genetic profile, despite having been disciplined internally for previous faulty DNA analyses.

DNA failures can border on the absurd, such as an incident in which German police tracked down a suspect whose DNA was mysteriously showing up every time they swabbed a crime scene, from murders to petty thefts. But instead of nabbing a criminal mastermind, investigators had stumbled on a woman who worked at a cotton swab factory that supplied the police. That case may seem comical, but a 2012 error in New York surely doesn’t. In July of that year, police announced that DNA taken off a chain used by Occupy Wall Street protesters to open a subway gate matched that found at the scene of an unsolved 2004 murder. The announcement was instantly followed by blaring news headlines about killer Occupiers. But officials later recanted, explaining that the match was a result of contamination by a lab technician who had touched both the chain and a piece of evidence from the 2004 crime. Yet the newspapers had already linked the words “Occupy” and “murder.” The episode demonstrates how the consensus surrounding DNA’s infallibility could plausibly enable government curtailment of dissent. Given the NYPD’s none-too-friendly disposition toward the Occupiers, one might wonder what motivated it to run DNA tests on evidence from protest sites in the first place.

The high degree of confidence placed in DNA is especially worrying because successful DNA analysis requires human institutional processes to function smoothly and without mistakes. The four authors of Truth Machine: The Contentious History of DNA Fingerprinting (2008) describe how DNA actually comes to be used in criminal proceedings: as “an extended, indefinitely complicated series of fallible practices through which evidence is collected, transported, analyzed, and quantified.” There are endless ways in which analysts can bungle their task. Furthermore, in the courtroom itself, DNA evidence must be contextualized and given significance. Even with well-conducted testing, poor explanation to a jury can enable a situation in which, as the geneticist Charalambos Kyriacou says, “Human error and misinterpretation could render the results meaningless.” A cautious approach is therefore valuable, even where DNA is concerned.

• • •

It would be unreasonable to expect any human endeavor to be completely without error, and one might wonder just how systemic the problems of forensic science truly are. The claim of crisis is far from universally shared. Forensic scientist John Collins calls this “a fabricated narrative constructed by frustrated defense attorneys, grant-seeking academics, and justice reform activists who’ve gone largely unchallenged.” Those who defend current practices say that the scandals are exceptions, that the vast majority of forensic scientists are diligent practitioners whose findings stand up under scrutiny. For every person exonerated, hundreds of convictions remain untouched.

But this defense actually points to one of the key problems with evaluating forensic science. The measures of its success are institutional: we see the failures of forensics when judges overturn verdicts or when labs contradict themselves. There is a circularity in the innocence cases, where the courts’ ability to evaluate forensic science is necessary to correct problems caused by the courts’ inability to evaluate forensic science. At no point, even with rigorous judicial review, does the scientific method come into play. The problem is therefore not that forensic science is wrong, but that it is hard to know when it is right.

Breaking the cycle of uncertainty has therefore been a key part of reform proposals. The NAS report recommended numerous steps to introduce objectivity and accountability, including the adoption of consistent standards in every subfield and the creation of a unified federal oversight entity. One can hear in the lengthy recommendations of the NAS committee members pleas for the introduction of basic quality control.

But so far changes have been sluggish. In fact, in some labs quality may be declining as state budget cuts have reduced resources available for forensics. In Congress, the Forensic Science and Standards Act, which would massively overhaul the field and introduce unprecedented scrutiny and coordination, has repeatedly stalled. Last year, in keeping with the NAS’s recommendations, the Department of Justice and the National Institute of Standards and Technology finally put together a forensic science commission to oversee the field and set protocols. But the commission is still in its infancy, and its effects remain to be seen.

The Supreme Court attempted to elucidate some standards in Daubert v. Merrell Dow Pharmaceuticals (1993) and two subsequent cases, which govern the admissibility of scientific evidence. The court ruled that evidence must be generally accepted in the field and open to empirical testing. But even as the Court ostensibly limited testimony to that which is sound and reliable, it undercut the ruling’s effectiveness by offering lower courts a high level of flexibility in their decision-making. Ironically, that hands-off approach may have helped to create the very nightmare that the Daubert court feared, in which “befuddled juries are confounded by absurd and irrational pseudoscientific assertions.”

Nobody can state with certainty the degree of pseudoscience that clogs the American courts. But even if forensic science largely faces a “bad apples” problem, it may still be in bad shape. As legal scholar and forensic science specialist Daniel Medwed notes, “An absence of careful oversight can allow rogue scientists to flourish.” Even if there is no reason to doubt forensic podiatry itself, there might still be good reason to doubt forensic podiatrists. The localized, disparate, and unmonitored nature of so much forensic practice makes for massive nationwide inconsistency.

In fact, so long as forensic science remains forensic—i.e., conducted to meet the demands of the forum rather than those of the scientific method—it is hard to see how it can warrant confidence. For countless reasons, law is a poor vehicle for the interpreting of scientific results. That people’s lives must depend on the interpretive decisions of judges and juries is in some respects unsettling to begin with. The chaotic state of forensic science—in theory and practice—and the possibility that unsupported flimflam is passing itself off as fact make the everyday criminal justice process even more alarming.

Thus even as we try various fixes, rooting out bad apples and introducing oversight, a systemic and elementary problem remains: a science of the forum can never be science at all.

25 Nov 12:58

Physicist says band Deerhoof inspires him like Einstein, asks them to rock at LHC

by Nathan Mattise
Austin.soplata

I think Erdos would've been more likely than Einstein to listen to Deerhoof...but regardless, this is awesome. This is so effing cool.

Didn't see this coming.

When we visited the CERN's Large Hadron Collider this past year, there wasn't a ton of noise. The massive particle accelerator facility took a two-year hiatus for repairs, and that break meant a rare chance for humans to tour things with less risk. 

Apparently things were considerably noisier last month, but it had nothing to do with the facilities getting back to business. As part of an initiative called Ex/Noise/CERN, ATLAS (A Toroidal LHC ApparatuS) physicist Dr. James Beacham invited experimental indie band Deerhoof to CERN’s magnet test facility, SM-18, in "honor of the LHC’s ramp up to 13 TeV." On site, Beacham wanted the band to experiment with noise and music much like his team experiments with particle physics.

“Musical curiosity is similar to scientific curiosity and, on a personal level, Deerhoof has inspired me as much as Einstein,” Beacham said in a project press release. “They’re explorers and this sense of exploration is what you feel in the air at CERN right now, and so the pairing of Deerhoof and CERN was natural.”

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24 Nov 18:47

Protein aggregates are associated with replicative aging without compromising protein quality control

by Saarikangas, J., Barral, Y.

Differentiation of cellular lineages is facilitated by asymmetric segregation of fate determinants between dividing cells. In budding yeast, various aging factors segregate to the aging (mother)-lineage, with poorly understood consequences. In this study, we show that yeast mother cells form a protein aggregate during early replicative aging that is maintained as a single, asymmetrically inherited deposit over the remaining lifespan. Surprisingly, deposit formation was not associated with stress or general decline in proteostasis. Rather, the deposit-containing cells displayed enhanced degradation of cytosolic proteasome substrates and unimpaired clearance of stress-induced protein aggregates. Deposit formation was dependent on Hsp42, which collected non-random client proteins of the Hsp104/Hsp70-refolding machinery, including the prion Sup35. Importantly, loss of Hsp42 resulted in symmetric inheritance of its constituents and prolonged the lifespan of the mother cell. Together, these data suggest that protein aggregation is an early aging-associated differentiation event in yeast, having a two-faceted role in organismal fitness.

DOI: http://dx.doi.org/10.7554/eLife.06197.001

30 Jun 18:50

Decisions reduce sensitivity

by Bronfman, Z. Z., Brezis, N., Moran, R., Tsetsos, K., Donner, T., Usher, M.

Behavioural studies over half a century indicate that making categorical choices alters beliefs about the state of the world. People seem biased to confirm previous choices, and to suppress contradicting information. These choice-dependent biases imply a fundamental bound of human rationality. However, it remains unclear whether these effects extend to lower level decisions, and only little is known about the computational mechanisms underlying them. Building on the framework of sequential-sampling models of decision-making, we developed novel psychophysical protocols that enable us to dissect quantitatively how choices affect the way decision-makers accumulate additional noisy evidence. We find robust choice-induced biases in the accumulation of abstract numerical (experiment 1) and low-level perceptual (experiment 2) evidence. These biases deteriorate estimations of the mean value of the numerical sequence (experiment 1) and reduce the likelihood to revise decisions (experiment 2). Computational modelling reveals that choices trigger a reduction of sensitivity to subsequent evidence via multiplicative gain modulation, rather than shifting the decision variable towards the chosen alternative in an additive fashion. Our results thus show that categorical choices alter the evidence accumulation mechanism itself, rather than just its outcome, rendering the decision-maker less sensitive to new information.

08 Jun 19:23

The Value of Basic Research

by Jo Handelsman

People’s appreciation of game-changing new technologies frequently ignores the long, often twisting path that transforms an idea from fundamental discovery to practical application.  Those who pay for the national research agenda may not always be aware of the early and fundamental work that makes today’s technologies possible.  For example, it was basic research presented in a then-obscure scientific paper by Albert Einstein in 1917 that ultimately translated into the invention of laser technology four decades later.  The development of similarly groundbreaking technologies that promise to transform and improve our lives hinges on our investments in fundamental, curiosity-driven research today. 

But basic science has long been under fire. Between 1975 and 1987, the “Golden Fleece Award” was established and bestowed upon projects they deemed “the biggest, most ridiculous or most ironic example of government spending or waste.” Often, the “winners” were Federally funded scientific research projects taken out of context and cited without explanation.

For instance, Golden Fleece Awards were given to:

  • Federal grants awarded to scientists seeking to determine why rats, monkeys, and humans clench their jaws.
  • A Government study on alcohol and aggression in fish and rats.
  • A Government-sponsored project to investigate the mating habits of the screwworm, an agricultural pest.

It was easy to call out these examples based on title alone. But, in an ironic (yet predictable) twist, each of these projects ultimately resulted in important and useful discoveries.

  • The jaw-clenching research helped NASA and the Navy address problems associated with confining humans to small spaces for extended periods in space and underwater.
  • Examining the effects of alcohol on aggression in fish and rats led to scientific insights about how alcohol affects people.
  • Understanding the mating habits of the screwworm led to the ultimate eradication of the pest through the use of sterile insects, saving the U.S. cattle industry approximately $20 billion.

The heyday of the Golden Fleece Award has passed, but misunderstanding of the value of basic research and its ties to valuable applications, products, and knowledge survives today.

This is particularly true in the area of social science, where discoveries are often less tangible and developed though unexpected paths. Game theory, for example, had its roots in an analysis of gambling behaviors in 1713. Subsequent work supported by the Federal Government generated far-reaching applications that have profoundly influenced predictions about economics, human behavior, and biological systems. Basic research on game theory enabled the Federal Communications Commission to design complex auctions of the Nation’s telecommunications spectrum, netting tens of billions of dollars to the U.S. treasury.

These examples underscore one of the most exciting features of scientific research: the process of exploring the natural world in pursuit of fundamental understandings can often deliver surprising new insights. Sometimes knowledge contributes to our understanding of the world around us; other findings may lead to practical applications now, or many years in the future.  One of the hallmarks of science is that the path to knowledge is often indirect, and that in addition to rigorous investigation, discovery is often shaped by serendipity, human curiosity, and sometimes even heroism.

That’s why President Obama has staunchly supported both curiosity-driven and mission-oriented research investments across his Administration, including $146 billion for R&D overall in his proposed FY 2016 Budget --  an $8 billion or 6 percent increase from 2015 enacted levels. The Administration is also speaking out against efforts to gut funding for Earth science research and the social sciences, and is similarly opposed to placing increased administrative burdens on scientific agencies that fund the kinds of fundamental research that keeps America on the cutting-edge.

The road to many of the next great scientific or technological advances will start with basic science. I encourage you to share your favorite examples of basic research that led to unexpected insights or game changing applications on social media using #BasicResearch

Jo Handelsman is Associate Director for Science at the White House Office of Science and Technology Policy.

08 Jun 18:24

Fatal Shootings By Police Twice As High As Official Number, Report Says

by Scott Neuman

An analysis by The Washington Post shows that the number of such incidents is more than twice as high as official federal figures.

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29 May 14:32

Ambiguity in the analysis of neural codes [Statistics]

by Amarasingham, A., Geman, S., Harrison, M. T.
Many experimental studies of neural coding rely on a statistical interpretation of the theoretical notion of the rate at which a neuron fires spikes. For example, neuroscientists often ask, “Does a population of neurons exhibit more synchronous spiking than one would expect from the covariability of their instantaneous firing rates?”...
20 May 14:58

Recognition: Build a reputation

by Azra Raza
Austin.soplata

AKA build your science rep brand. And get on Twitter! The amount of science communication on Twitter is suprisingly large/good! I build a "list" of people to follow about open computational neuroscience here, https://twitter.com/austinsoplata/lists/opencompneuroscience but that's just the start of the iceberg.

Chris Woolston in Nature:

CareerLess than a decade after receiving her undergraduate degree in biology, Holly Bik has transformed herself. When she started her PhD, she was as an aspiring marine biologist with a deep interest in nematode worms. Today, she is a highly regarded interdisciplinary computational and evolutionary biologist who travels the world to give talks on topics that range from use of social media to what she dubs 'ecophylometamicrobiomics' — the identification of eukaryotic microbes in the environment through sequencing. Now at the University of Birmingham, UK, she has led the development of the data-visualization platform Phinch and is actively involved in three working groups tackling issues as diverse as the evolution of indoor microbial communities and the biodiversity of the deep sea.

It is all a big leap from worms. How did she become such a sought-after figure in the science community? The key to property is said to be location, location, location; in science, it's all about reputation, reputation, reputation. “I'm trying to cultivate a reputation as an interdisciplinary researcher,” says Bik. “Marine biology, computer programming, genomics — I want people to think of me as a potential collaborator.” If science were truly a double-blind enterprise, generic researchers X, Y and Z would compete for citations, grants, invited talks and promotions solely on the basis of their accomplishments and aptitude. In the real world, scientists have names, and those names come with baggage, both positive and negative. In an increasingly competitive scientific environment, a reputation may matter more than ever, says Philip Bourne, associate director for data science at the US National Institutes of Health (NIH) in Bethesda, Maryland. “The degree of separation between any two scientists is relatively small,” Bourne says. “If you're colossally brilliant, you can be a jerk and still have a good reputation. But if you're a mere mortal, the way you treat science and the people around you will come back on you.”

More here.

18 May 22:01

Furious Fred

by jon
Austin.soplata

i need to see dis

2015-05-18-Furious-Fred

Mad Max has never been about feminism! Unless you count the Warrior Woman from Road Warrrior or Aunty Entity from Beyond Thunderdome or… What? You’re not interested in concrete examples from the history of the franchise? You say you’d rather maintain a self-serving headcanon of hate? Hey, I’m not here to stop you. Go for it, dudes.

goat-mcase[1]

The post Furious Fred appeared first on Scenes From A Multiverse.

18 May 19:07

FBI now claims its stingray NDA means the opposite of what it says

by Cyrus Farivar
Austin.soplata

It's very strange to me that the cops/FBI would seem to be doing everything in their power to prevent all but the most general details on this specific technology - I didn't realize, as mentioned in the article, that they have even dropped cases where the defendants pled guilty, just to prevent exposure of the technology. My guess is there's something either about the technology or the FBI's internal legal justification of stingrays that is highly embarrassing, etc.

The FBI has released a statement regarding the use of stingrays, which apparently claims the opposite of what its nondisclosure agreement (NDA) with local law enforcement actually says.

According to The Washington Post, which quoted from but did not publish the statement on Thursday, the FBI doesn’t actually prevent local law enforcement from disclosing stingray use.

Ars received a copy of the statement from the FBI early Friday morning and is publishing it in full here for the first time.

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18 May 19:02

How Big Is The Brain's Penis Area?

Austin.soplata

A comparison across genitalia would be more inclusive, and interesting. Still, lol.

Rolf Degen has an interesting post on the question of how much of the brain is devoted to processing touch stimuli from the penis. The Fake Homunculus: A new book about sex depicts a beefed-up representation of the penis in the human brain Everybody has once already seen a picture of the Sensory Homunculus - a humanized image of the relative amount of cerebral cortex space devoted to processing the tactile input from the different body parts. It appears grotesquely disfigured, because so
18 May 18:35

The Real Historical Wars That Inspired Game Of Thrones

by Robin Varghese

Via io9:

18 May 17:40

Imprisoned Nuclear Activist Nun Granted Victory On Appeal

by Carrie Johnson
Austin.soplata

GOOD. But what about the 2 others? The notion that the ninja nun intended to hurt national defense/security is ridiculous, and more than anything was probably just a retaliation for how embarrassing it was for the gov.

A federal appeals court thew out the most serious charge, sabotage, against 85-year-old Sister Megan Rice. Her case gained attention after supporters said she was being held in unfair conditions.

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04 May 16:40

Alito and Scalia: Have You No Sense of Decency Sirs?

by stclair
Austin.soplata

I'm no fan of said justices either, but isn't Socratic-style, "let's take your assumption to an insane crazy implication" for the purposes of arguing about future possibilities merely part of the day-to-day of SCOTUS? I mean of course a Justice could harp on an issue too much, but AFAIK it's pretty typical in SCOTUS discussion to talk about possible consequences, even if they seem remote. I'm unclear how much of SCOTUS' discussion is A. discussion in the abstract vs. B. discussion of, given the specific law being upheld/strick down here, what would this specific legal conclusion allow? Isn't it entirely possible that, from a legal standpoint alone, doing said legal action WOULD "open the door" to polygamy, etc. (depending on the precedent of other laws of course)? And thus it would need to be discussed. That is not at all the same thing as red-baiting.

In the 1940s and 1950s, countless people in the US were being bullied and brutalized by the anti-communist scare tactics and character assassinations of Senator Joseph McCarthy. The end of the McCarthy red-baiting era began when Joseph Welch stood up to McCarthy after he attacked a young lawyer on his staff. Welch was appalled by McCarthy’s callous disregard and despite McCarthy’s power, challenged him by stating: “Until this moment, Senator, I think I have never really gauged your cruelty or your recklessness.” He concluded by saying “You’ve done enough. Have you no sense of decency, sir? At long last, have you left no sense of decency?”

In the recent marriage equality case, Supreme Court Justices Samuel Alito and Antonin Scalia argued that marriage equality opens the door to polygamy, underage sex, and incest between brothers and sisters. This is the modern equivalent of McCarthy red-baiting and deserves the same response.

The cruel, illogical, heartless and hateful arguments of Alito and Scalia give considerable support and inspiration to right wing groups who literally demonize our sisters and brothers and sons and daughters who seek only to marry their same sex partners just like the rest of us.

Alito and Scalia give comfort to the likes of Rush Limbaugh who stated marriage equality leads to incest. To Rick Santorum who compares same sex relationships to bestiality and pedophilia. To the head of ironically named American Decency Association who claimed that gay rights is a satanic attack on the US. And to legions of other people and groups who practice hostility and violence against our sisters and brothers.

It is one thing to have these fringe haters outside on the courthouse steps. We allow the Ku Klux Klan and the Nazi parties to demonstrate out on the steps. It is another matter entirely when they are in the exalted position as members of the court and while there feeding the fires of hatred in their public arguments.

It is past time for family, friends, lawyers, legal associations and law schools to ask Alito and Scalia to halt and to answer the question “Have you no sense of decency, sirs?”

Alito, long criticized for being a cranky, malicious mouthpiece of the anti-gay movement, was at it again when the court heard the marriage equality case. Alito is already famous for visibly shaking his head and mouthing opposition to President Obama in his 2010 State of the Union address and for throwing a mini-tantrum when other justices dissent.

Alito argued that approving the right to marriage equality for gay and lesbian people would open the door for 12 year olds to marry, for brothers and sisters to marry, and make polygamy possible for four lawyers who all want to marry each other. Alito’s problems are so often raised and widely known that they are characterized as his “polygamy perplex” by The New Yorker.

Alito’s fallacious slippery slope arguments, transparently couched as questions, were so ridiculous that they prompted John Stewart to ask whether, in the case where women fought for the right to vote, Alito might have asked “What if one day a dog wants to vote? How about that ladies?

Antonin Scalia, of course not to be outdone, argued that if marriage equality was recognized ministers would be forced to conduct such marriages even if their religious organizations opposed them. When Justice Sonia Sotomayor pointed out that no ministers have ever been forced to conduct gay marriages Scalia would not hear of it. When the lawyer arguing the case and Justices Breyer and Kagan pointed out that the First Amendment already protected priests, rabbis, imams and ministers from conducting marriages inconsistent with their religions, Scalia refused to concede. Scalia, like Alito, also asked if marriage equality means polygamy would have to be recognized.

As one wise friend pointed out, our country still has the Ku Klux Klan but we do not take their arguments seriously. And there are no respected people openly espousing their arguments on the Supreme Court. No respected person openly argues that blacks and whites should not marry. Nor do any people argue openly that women do not deserve the right to vote. Yet, there are people on the Supreme Court who continue to openly repeat the brutally crude applause lines of right wing anti-gay hate groups. It is time that stopped.

It is time all people of good will stand up to the haters, especially those on the Supreme Court, and say, “Until this moment, Justices, I think I have never really gauged your cruelty or your recklessness…You’ve done enough. Have you no sense of decency, sirs? At long last, have you left no sense of decency?”

Bill Quigley is a human rights lawyer who teaches law at Loyola University New Orleans.

01 May 15:13

Two Boston groups get $2.5 million to study brain cells

by Nidhi Subbaraman
The Paul G. Allen Family Foundation has a history of betting on risky but potentially world-changing science. This year, the group earmarked a total of $7.5 million for basic neuroscience and six groups of US researchers, including two in Boston, will receive the amount over three years.  Read More
28 Apr 14:18

Does peer review ferret out the best science? New study tries to answer

by Alison McCook

Grant reviewers at the U.S. National Institutes of Health are doing a pretty good job of spotting the best proposals and ranking them appropriately, according to a new study in Science out today. Danielle Li at Harvard and Leila Agha at Boston University found that grant proposals that earn good scores lead to research that […]

The post Does peer review ferret out the best science? New study tries to answer appeared first on Retraction Watch.

28 Apr 13:49

This Microsoft ad paints a terrifying future where employees are working literally 24 hours a day

by Christopher Ingraham
Austin.soplata

Why pay attention to your kid at their soccer game when you can be answering emails from your boss or working on reports?

"#GetItDone: Office workers want technology to help them get things done anywhere, sunrise to sunset." That's the chipper headline of a Microsoft infographic that's currently going viral on social media, although not for the reasons the company intended.

The ad pairs findings from a poll of employees' remote-work habits with vignettes about all the ways you can stay productive outside of the office, 24/7/365. For instance, you could be getting work done on the john like 19 percent of your colleagues, according to Microsoft.

For the full post, head over to Wonkblog.








16 Apr 05:10

Rule rewrite aims to clean up scientific software

by Erika Check Hayden

Rule rewrite aims to clean up scientific software

Nature 520, 7547 (2015). http://www.nature.com/doifinder/10.1038/520276a

Author: Erika Check Hayden

Nature Biotechnology asks peer reviewers to check accessibility of code used in computational studies.