24 Apr 12:01
by Lehui Lu,
Weihua Chen,
Zhen Sun,
Chunhuan Jiang,
Wenbo Sun,
Bin Yu,
Wei Wang
Gram-scale organic semiconductor C5N2 NPs were synthesized by a one-pot bottom-up method. The all-in-one semiconductor, with a low band gap of 1.63 eV and inherent nucleus targeting and strong photooxidation capacity, could accumulate at cell nucleus, split H2O to produce O2 and also generate cytotoxia 1O2 under high-tissue-penetrable NIR irradiation, successfully achieving effective and enhanced PDT in a hypoxic tumor.
Abstract
Tumor hypoxia severely limits the therapeutic effects of photodynamic therapy (PDT). Although many methods for oxygen generation exist, substantial safety concerns, spatiotenporal uncontrollability, limited efficacy, and complicated procedures have compromised their practical application. Here, we demonstrate a biocompatiable all-in-one organic semiconductor to provide a photoxidation catalysis mechanism of action. A facile method is developed to produce gram-level C5N2 nanoparticles (NPs)-based organic semiconductor. Under 650 nm laser irradiation, the semiconductor split water to generate O2 and simultaneously produce singlet oxygen (1O2), showing that the photocatalyst for O2 evolution and the photosensitizer (PS) for 1O2 generation could be synchronously achieved in one organic semiconductor. The inherent nucleus targeting capacity endows it with direct and efficient DNA photocleavage. These findings pave the way for developing organic semiconductor-based cancer therapeutic agents.
06 Apr 04:22
by Ke Li, Jian Yang, and Jinlou Gu
Chemistry of Materials
DOI: 10.1021/acs.chemmater.1c00123
27 Feb 02:45
by Chu‐Xin Li,
Yu Zhang,
Xue Dong,
Lu Zhang,
Miao‐Deng Liu,
Bin Li,
Ming‐Kang Zhang,
Jun Feng,
Xian‐Zheng Zhang
A live cell‐typed therapeutic is engineered for tumor treatment by reprogramming macrophages with HION nanoparticles. The advantage of this ex vivo cell‐reprogramming strategy is evidenced by cancer cell‐specific toxicity, more efficient production of bioactive components, stronger resistance against intratumoral immunosuppression, and favorable ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine‐like manner.
Abstract
To engineer patient‐derived cells into therapy‐purposed biologics is a promising solution to realize personalized treatments. Without using gene‐editing technology, a live cell‐typed therapeutic is engineered for tumor treatment by artificially reprogramming macrophages with hyaluronic acid‐decorated superparamagnetic iron oxide nanoparticles (HIONs). This nanoparticle‐assisted cell‐reprogramming strategy demonstrates profound advantages, due to the combined contributions from the biological regulation of HIONs and the intrinsic nature of macrophages. Firstly, the reprogrammed macrophages present a substantial improvement in their innate capabilities, such as more effective tumor targeting and more efficient generation of bioactive components (e.g., reactive oxygen species, bioactive cytokines) to suppress tumor growth. Furthermore, this cell therapeutic exhibits cytostatic/proapoptotic effects specific to cancer cells. Secondly, HIONs enable macrophages more resistant to the intratumoral immunosuppressive environment. Thirdly, the macrophages are endowed with a strong ability to prime in situ protumoral M2 macrophages into antitumor M1 phenotype in a paracrine‐like manner. Consequently, a synergistic tumor‐inhibition effect is achieved. This study shows that engineering nanomaterial‐reprogrammed live cells as therapeutic biologics may be a more preferable option to the commonly used approaches where nanomaterials are administrated to induce bioresponse of certain cells in vivo.
21 Sep 10:40
by Alexander J. Burckle, Bálint Gál, Frederick J. Seidl, Vasil H. Vasilev and Noah Z. Burns
Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07792
