Real-time measurement of protein–protein interactions at single-molecule resolution using a biological nanopore
Real-time measurement of protein–protein interactions at single-molecule resolution using a biological nanopore, Published online: 10 December 2018; doi:10.1038/nbt.4316
Single-molecule analyses of transient protein–protein interactions are enabled using an engineered biological nanopore.Biopharmaceutical benchmarks 2018
Biopharmaceutical benchmarks 2018, Published online: 06 December 2018; doi:10.1038/nbt.4305
Monoclonal antibodies (mAbs) continue to reign supreme, although cellular and gene therapies are slowly starting to gather momentum. Burgeoning growth in biosimilars may threaten future brand monopolies for mAbs and other biologics.High-throughput determination of the antigen specificities of T cell receptors in single cells
High-throughput determination of the antigen specificities of T cell receptors in single cells, Published online: 12 November 2018; doi:10.1038/nbt.4282
The antigen specificity of T cell receptors is measured at high throughput in single cells.Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo
Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy <i>in vivo</i>, Published online: 13 August 2018; doi:10.1038/nbt.4195
Anti-PD-1 secreted by CAR-T cells remains localized to the tumor and improves therapeutic outcome in mice.A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life
A standardized bacterial taxonomy based on genome phylogeny substantially revises the tree of life, Published online: 27 August 2018; doi:10.1038/nbt.4229
Interpretation of microbial genome data will be improved by a fully revised bacterial taxonomy.