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29 Jul 02:30

Gulf Coast tests confirm deadly tropical soil bacterium now endemic to US

by Beth Mole
<Em>Burkholderia pseudomallei</em> grown on sheep blood agar for 24 hours. <em>B. pseudomallei</em> is a Gram-negative aerobic bacteria, and it's the causative agent of melioidosis.

Enlarge / Burkholderia pseudomallei grown on sheep blood agar for 24 hours. B. pseudomallei is a Gram-negative aerobic bacteria, and it's the causative agent of melioidosis. (credit: Getty | CDC/Courtesy of Larry Stauffer, Oregon State Public Health Laboratory)

For years, health officials in the US noted sporadic, mysterious cases of a foreign bacterial infection, called melioidosis. The infection—which is difficult to diagnose, tricky to treat, and often deadly—was thought to only strike travelers or those who came in contact with contaminated imported goods or animals. Yet, now and then, an American would inexplicably fall ill—no recent travel, no clear links.

Now, health officials have a definitive explanation. And it confirms a dreaded, long-held suspicion: The deadly bacterium is foreign no more. Rather, it's a permanent US resident entrenched in American soil.

Three samples taken from soil and puddle water in the Gulf Coast region of southern Mississippi tested positive for the bacterium, officials from the Centers for Disease Control and Prevention announced Wednesday. The sampling was part of an investigation into two mysterious cases in the area that occurred in 2020 and 2022. The positive test results mark the first time that investigators have caught the deadly germ in US environmental samples, though they've been looking for it for years.

Read 22 remaining paragraphs | Comments

28 Jul 20:56

My Conversation with Leopoldo López

by Tyler Cowen
Jack

Interesting to hear from a former political prisoner. It’s depressing that most of my mom’s side of the family are still in Venezuela.

Here is the audio, video, and transcript.  Here is the CWT summary:

As an inquisitive reader, books were a cherished commodity for Leopoldo López when he was a political prisoner in his home country of Venezuela. His prison guards eventually observed the strength and focus López gained from reading. In an attempt to stifle his spirit, the guards confiscated his books and locked them in a neighboring cell where he could see but not access them. But López didn’t let this stop him from writing or discourage his resolve to fight for freedom. A Venezuelan opposition leader and freedom activist, today López works to research and resist oppressive autocratic regimes globally.

López joined Tyler to discuss Venezuela’s recent political and economic history, the effectiveness of sanctions, his experiences in politics and activism, how happiness is about finding purpose, how he organized a protest from prison, the ideal daily routine of a political prisoner, how extreme sports prepared him for prison, his work to improve the lives of the Venezuelan people, and more.

And one excerpt:

COWEN: In 1970, you were richer than Spain, Greece, or Israel, which I find remarkable. But do you, today, ever look, say, at Qatar or United Arab Emirates, Dubai, and think the problem actually was democracy, and that here are oil-rich places that have stayed stable, in fact, but through autocratic rule, and that it’s the intermediate situation that doesn’t work?

LÓPEZ: Well, I think that I, personally, will always be in favor of a democratic regime, a democratic system that promotes a rule of law, the respect for human rights, the respect of freedoms. I think that’s a priority. For me it is, and I believe it’s a priority also for the large, large majority of the Venezuelan people that want to live in a democracy.

However, there has been great mismanagement due to misconceptions of the economy, to a state-led economy that did not open possibilities for a private sector to flourish independently of the state, but also with the level of corruption that we have seen, particularly over the past 22 years — it’s what has led Venezuela to the situation in which we are.

In Venezuela, you could argue that we did much, much better economically, and in terms of all of the social and economic standards, than what happened during these last 20 years of autocracy. This autocracy had the largest windfall and the largest humanitarian crisis.

During the democratic period of 40 years, Venezuela became one of the most literate countries in Latin America, with the largest amount of professionals being graduated every year, with the best in social, health, and education standards, vaccination rates, housing programs that were in Latin America. So, we did perform much better under the democratic period than has been the performance by any means in the autocratic regimes of the last 22 years.

Interesting throughout.

The post My Conversation with Leopoldo López appeared first on Marginal REVOLUTION.

28 Jul 18:27

Wednesday Thread

by Milan Singh
28 Jul 16:51

Incentives matter, installment #5637

by Tyler Cowen
Jack

Its something at least

America needs more than 5 million new houses to meet demand, according to a study last year by Realtor.com. With sales of existing homes slowing, the need for more new houses is only growing. Florida, my home state, might have found part of the solution: Reform the permitting process so that building houses is easier.

Last year, Gov. Ron DeSantis (R) signed a bill that fundamentally changes the state’s permitting process for home building. It requires local jurisdictions to post online not only their permitting processes but also the status of permit applications. The transparency takes a good amount of mystery out of what can be an inscrutable branch of bureaucracy.

More important, the reforms also created a system that strongly incentivizes cities and counties to approve new home permits in a timely way. When a builder or property owner submits an application to build a new home, cities and counties have 30 business days to process it or request corrections.

If the government offices fail to respond in that time frame, the locality must refund 10 percent of the application fee for every additional business day of silence. Application fees can vary widely by locality, but the average cost in Florida is nearly $1,000, according to HomeAdvisor.com. If officials request corrections to the application, they have 10 business days to approve or disapprove of the resubmitted application. Blowing past that deadline leads to an automatic 20 percent refund, with a further 10 percent added for each additional missed day, up to a five-day cap.

And this:

A study of housing sales in southwest Florida between 2007 and 2017 by the James Madison Institute found that permitting delays added as much as $6,900 to the cost of a typical house. That’s a de facto tax on Florida families; now the Sunshine State is making cities and towns pay for their own delays.

Here is the full story, via the excellent Kevin Lewis.

The post Incentives matter, installment #5637 appeared first on Marginal REVOLUTION.

28 Jul 16:48

Ireland fact of the day

by Tyler Cowen
Jack

I’m way passed any of these ages lol. The US average seems young to me but I’m sure people used to get married much younger back in the day, not my parents though.

It appears that, in 2020, Ireland overtook South Africa as having the latest marrying couples worldwide.

The average age for a groom is 37.8 and for a bride is 35.7, for opposite-sex couples. This is the fairer comparison because same-sex marriages obviously aren’t allowed everywhere and are less relevant to reproduction.

37.8!

If you consider first-time marriages only, the average age of grooms marrying for the first time was 35.7 years and for brides the average age was 34.2 years.  By comparison, for first-time marriages the United States is 30.5 for males and 28.6 for females.

That is from Sam Enright, with an assist from Fergus McCullough.

The post Ireland fact of the day appeared first on Marginal REVOLUTION.

26 Jul 19:21

China targeted the Fed to build an informant network

by Tyler Cowen

Duh, but good to see this coming out in the WSJ.  Excerpt:

China tried to build a network of informants inside the Federal Reserve system, at one point threatening to imprison a Fed economist during a trip to Shanghai unless he agreed to provide nonpublic economic data, a congressional investigation found.

The investigation by Republican staff members of the Senate’s Committee on Homeland Security and Governmental Affairs found that over a decade Fed employees were offered contracts with Chinese talent recruitment programs, which often include cash payments, and asked to provide information on the U.S. economy, interest rate changes and policies, according to a report of the findings released on Tuesday.

If you are surprised by any of this, you have not been paying attention.  Good work by Kate O’Keefe and Nick Timiraos.

The post China targeted the Fed to build an informant network appeared first on Marginal REVOLUTION.

24 Jul 18:46

It could be up to 3 years before flight capacity and pilot supply are 'back in sync,' American Airlines CEO says

by kbalevic@insider.com (Katie Balevic)
Boeing 787 Dreamliner American Airlines. Aircraft to Fiumicino Leonardo da Vinci Airport. Fiumicino, Italy, on July 14th, 2022.
The Boeing 787 Dreamliner American Airlines aircraft near Fiumicino Leonardo da Vinci Airport in Fiumicino, Italy, on July 14th, 2022.

Massimo Insabato/Getty Images

  • American Airlines CEO on Thursday said it could be years before flight capacity returns to normal. 
  • It may take a year for capacity to stabilize for the airline's main routes, CEO Robert Isom said.
  • The airline recently canceled hundreds of summer flights amid an ongoing pilot shortage. 

The CEO of American Airlines on Thursday said it could be two to three years before flight capacity returns to normal amid an ongoing staffing and pilot shortage.

CEO Robert Isom told investors that demand for flights has surged up while the supply of staff and pilots is struggling to keep up, NBC News reported.

Isom said it would take approximately one year to get the airline's main flight routes back to full capacity and two to three years for the regional routes. 

"I think it's dependent on the supply chains of aircraft manufacturers and ultimately, pilot supply to get all back in sync," Isom said, per NBC. "From a regional perspective, it's just going to take a little bit longer than that, maybe 2 or 3 years, to kind of get the supply chain for pilots back to where we need it to be."

It comes after the airline canceled an additional 1,200 summer flights to minimize flight schedule disruptions, Insider previously reported. Allied Pilot Association, the union for American Airlines pilots, told its members that the airline was "once again acknowledging that they cannot honor their published schedule." 

Summer travel on the airline (and most others) has been wrought with cancellations, delays, and lost luggage. One family described a frantic phone call from their 10-year-old daughter who was traveling as an unaccompanied minor when American Airlines canceled her connecting flight without informing her parents. Another couple described their flight being canceled twice, leaving them stranded in Mexico

The airline recently offered pilots pay raises of up to $64,000 in an attempt to combat the shortage. Meanwhile, Allied Pilots union members are planning to picket in Chicago on July 26 to "send management a clear message" as they work to improve conditions for pilots.  

Read the original article on Business Insider
23 Jul 03:01

Nearly 90% of American homes are now using AC

by Clarisa Diaz
Jack

That’s a pretty extreme difference.

Americans have been cranking up the AC as heatwaves become more frequent. Nearly 90% of American homes are using some form of air conditioning, according to recently released data from the US Energy Information Administration (EIA).

For comparison, less than 10% of households in Europe have an AC unit—though that number is predicted to increase as extreme summer temperatures like the ones currently scorching the region become more common.

Hotter and longer summers mean dangerous conditions for people exposed to extreme heat and humidity. Low-income and other vulnerable populations are particularly at risk of heat stress, heat stroke, and death without some form of cooling. At the same time, higher AC usage is straining the electrical grid and boosting carbon emissions that will further contribute to global warming.

Read the rest of this story on qz.com. Become a member to get unlimited access to Quartz’s journalism.

23 Jul 03:01

Is Netflix’s best hope an acquisition by Microsoft?

by Adario Strange
Jack

Yes. Although I think Samsung or even Sony wouldn’t be terrible ideas.

Underpromise and overdeliver appears to have worked this week for Netflix. Its share price is up 11% since July 19, when its second-quarter earnings report was released. Revenue growth slowed way down, but the company lost just 970,000 subscribers in the quarter, versus expectations for a drop of 2 million.

Is that what counts for good news now at Netflix?

As far back as 2019 and up until the first quarter of 2021, the streaming giant regularly logged year-over-year revenue growth between 24% and 30%. But in the last two quarters, revenue growth has plummeted to single digits, with the second quarter yielding just 8.6% growth and Netflix forecasting roughly 5% growth for its third quarter in 2022.

Read the rest of this story on qz.com. Become a member to get unlimited access to Quartz’s journalism.

23 Jul 00:01

Are Starbucks and Chipotle union-busting by closing stores?

by Sarah Todd
Jack

I assume this is rhetorical

Big chains open and close stores all the time as a matter of course. But recent moves by Starbucks and Chipotle to close US stores in the wake of employee organizing efforts are drawing allegations from workers and labor advocates that the companies are engaging in union-busting.

Starbucks announced last week it was closing 16 US stores over concerns about crime and other community safety issues, including two stores that are unionized and one that had scheduled a union election. The company also closed a unionized store in Ithaca, New York, in June, citing concerns about the store’s faulty grease trap as well as problems with staffing.

Howard Schultz, the coffee chain’s CEO, added in a video posted to Twitter last week that the company will be shuttering more stores over safety issues going forward: “This is just the beginning. There are going to be many more.” Starbucks has not yet replied to Quartz’s request for comment.

Read the rest of this story on qz.com. Become a member to get unlimited access to Quartz’s journalism.

23 Jul 00:01

Marvel’s ‘Infinity Stones’ Gem Collectibles To Cost $25 Million, Won’t End Universe

by David Bloom, Senior Contributor
Jack

I’m surprised it took this long…

Please note that the below is embargoed until Friday, July 22 at 1:30PM PT.
23 Jul 00:00

In the UK, design is still largely a man’s job

by Anne Quito
Jack

Wow. How is this still possible?

Is the design sector really still an all-boys club? A new report from the UK Design Council implies as much.

The Design Economy: The People, Places and Economic Value, published by the London-based charity this week, found that 77% of the country’s estimated 1.6 million designers identify as male—an imbalance that has persisted since 2016. The report’s authors consulted data from the UK Office for National Statistics and workforce sites like the O-Net labor database. They also polled 1,300 UK-based designers, party to account for transgender or non-binary respondents that the publicly available data don’t account for. In the survey, 2% identified as non-binary and 0.8% as transgender.

While the 77% number is alarming, understanding the Design Council’s findings requires digging into the nuance.

Read the rest of this story on qz.com. Become a member to get unlimited access to Quartz’s journalism.

22 Jul 23:59

Twitter is blaming Elon Musk for its poor second-quarter results

by Scott Nover
Jack

It’s not like it has been terribly run for years..

Twitter kept its earnings report simple for the second fiscal quarter of 2022. The social media company did not hold its usual conference call in which executives take questions from financial analysts. Citing Elon Musk’s pending $44 billion takeover, Twitter merely posted its results on its website.

While Twitter’s user base rose 16.6% year over year to 237.8 million, the social media company’s revenue fell 1% to $1.18 billion during that period. Results were worse than expected: On average, according to FactSet, analysts predicted revenue would hit $1.32 billion. The company swung to a net loss of $270 million, after posting a profit of $65 million this time last year.

Twitter cited “advertiser industry headwinds associated with the macroenvironment as well as uncertainty related to the pending acquisition of Twitter by an affiliate of Elon Musk.”

Read the rest of this story on qz.com. Become a member to get unlimited access to Quartz’s journalism.

21 Jul 22:28

The worse, the better?

by ssumner
Facebook Twitter LinkedIn

Lenin felt that way about Czarist Russia, but is that how the Democratic leadership should feel about the GOP?

Apparently, the Democratic Governors Associations is with Lenin. Here’s Reason:

Yesterday was Maryland’s primary election day. The winner of the Republican gubernatorial primary was supported by both former President Donald Trump and the Democratic Governors Association. Why is that? . . .

In Pennsylvania, Democratic nominee Josh Shapiro ran ads boosting Republican candidate Doug Mastriano, a state senator who insists the 2020 presidential election was stolen. Mastriano ultimately won the nomination, and now has a fighting chance of winning not just the governorship, but the power to hand-pick a secretary of state who may throw the 2024 election into chaos. . .

[T]he DGA spent $1.2 million on an ad targeting Cox, more than twice what Cox had raised to that point. The ad highlighted Trump’s endorsement, and claimed Cox was “fighting to end abortion in Maryland” and “will protect the Second Amendment at all costs, refusing to support any federal restrictions on guns, even pushing to put armed guards in every school.”

While likely horrifying Democrats, the ad goosed Cox’s prospects among Republicans: He ultimately beat Schulz by more than 15 percentage points. Like Mastriano, Cox participated in the January 6 Capitol riot, busing people to Washington ahead of time and tweeting “[Vice President Mike] Pence is a traitor” after protesters had already breached the building.

The GSA strategy is too cynical even for someone like me. After all, Democrats are Americans, aren’t they? It’s inevitable that the Dems will win some elections and lose some elections. When they lose, wouldn’t it be better if the victorious GOP opponent were not evil?

It’s bad enough that the GOP is being taken over by right wing nuts. The fact that the Democrats are encouraging this shift is even worse. Just one more indication that America has become a banana republic.

Bloomberg has the following headline:

Good News for Democrats: Even Republicans Are Tiring of Trump

I don’t believe that; the betting markets still show Trump as being almost twice as likely to win the next presidential election as is the next most popular candidate (which is not Biden, in case you are interested.) But if the DGA is correct, then news of Trump’s (alleged) falling popularity should be discouraging to Dems. After all, it would be easier for the Dems to beat Trump than DeSantis. (To be clear, I don’t believe they’d beat either. I’m just saying that Trump is clearly the weaker candidate.)

PS. I read that some of the MPs that support Rishi Sunak strategically voted for Liz Truss, believing her to be the weaker foe in the next round. Betting markets now have Truss as the favorite to beat Sunak.

PPS. Was it a mistake to unify Italy? The country seems increasingly dysfunctional. Let’s not forget that it all began in Italy with the election of Berlusconi. By “it”, I mean the banana republicization of much of the world. Italy was the canary in the coal mine, heralding that the 21st century was going to suck.

Forza Italia! Yeah, how’d that work out?

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21 Jul 22:18

From my email, on the market for programmers

by Tyler Cowen

Programmers in the US are well-paid and companies report difficulty hiring programmers. At the same time, while it’s less reported, there are a lot of people who are good at programming but can’t get programming jobs.

There’s a simple explanation, and it’s one that I’ve validated in several ways since realizing it: companies only want to hire already-employed programmers. There’s little incentive to hire someone not already working as a programmer, because if you pay them less than the market rate, they’ll leave after a year, and it takes months to get net productivity from them. (This is great for that person, but the company doesn’t care.) There’s also a big difference between good and bad programmers that can be hard for non-technical managers to determine.

There are some developer jobs specifically for new graduates, but fewer than there are computer science graduates alone, and only at certain companies. There’s also a limited window to get one after graduating. Some people can get jobs after a coding bootcamp, yes – but in general, only people in demand for DEI reasons can actually do that, and any technical college degree works about equally well.

The higher developer salaries get, the more unqualified people apply, the higher search costs get, and the more companies are disinclined to hire people who aren’t already working as developers.

That is from bhauth.

The post From my email, on the market for programmers appeared first on Marginal REVOLUTION.

06 Sep 15:14

How 'rain drones' in Dubai use electric shocks against clouds to trigger rain to battle extreme temperatures

by insider@insider.com (Carlos Ferrer-Bonsoms,Qayyah Moynihan)
lightning in dubai
Cloud seeding can increase low annual rainfall.

Getty Images

  • Dubai launched a project to cope with high temperatures.
  • The project is based on Dubai creating its own rain.
  • To do this, drones that discharge electrical charges are used.
  • See more stories on Insider's business page.

Fighting the heat isn't always easy but in places like the United Arab Emirates where temperatures can easily reach 120 degrees Fahrenheit at certain times of the year.

In the UAE - specifically in Dubai - scientists have started tackling high temperatures by creating their own rain.

Dubai is now using drones that fly towards the clouds and discharge electrical charges to produce rain, Vanguard reported.

The charges cause the clouds to gather together to produce rain.

The technique is called "cloud seeding," and is used to help increase low annual rainfall - and it seems to be working.

These cloud seeding efforts are part of an ongoing $15 million project by the United Arab Emirates to generate rainfall in the country.

The technology was created by experts at the University of Reading in the UK.

Professor Maarten Ambaum, who worked on the project, said the Emirates had enough clouds to create conditions that would allow rain.

"When the drops merge and are big enough, they will fall as rain" Professor Ambaum told the BBC, according to Vanguard.

The UAE is also looking at methods of preserving the rain that hits the ground, rather than allowing it to evaporate.

To this end, the country has about 130 dams and dikes with a storage capacity of 120 million cubic meters, according to the ministry.

NCMS executive director Abdulla al-Mandoos said studies were being prepared to plan more dams and protect water, with the aim of directing rain "from the cloud to the aquifer."

"We do not want to waste a drop of water," he added.

Read the original article on Business Insider
06 Sep 14:35

COVID Led to Massive Improvements in State Cottage Food Laws

by Baylen Linnekin
homecook

Recent updates to already popular cottage food laws in a number of states will help home cooks connect in a variety of ways with more consumers. And that's great news for everyone who cooks, eats, or both.

As I've detailed in my book and many columns, cottage food laws are a class of legislation that deregulates some food sales by eliminating the need for budding food entrepreneurs to lease expensive commercial kitchen space, thus allowing people of all stripes to sell homemade foods they produce in their home kitchens. In that way, cottage food laws enable people to help support themselves and their families while working from home. That's particularly essential today because the Covid-19 pandemic has caused many Americans either to lose work—from bona fide chefs to talented home cooks who've been laid off from other fields—or required them to work from home.

While every state now has a cottage food law in place—welcome New Jersey!—the quality of these laws varies widely. Generally, state cottage food laws contain any number of limitations—as this 2018 Harvard Food Law & Policy Clinic report details—including rules for licensing, permitting, and inspection; labeling requirements; restrictions on the types of foods that may be sold; limitations on place of sale; and sales caps.

Given these potential restrictions, state cottage food laws can differ wildly, and are often crying out for improvement. A decade ago—in a Hit & Run blog post on "the many inane requirements of New York State's cottage foods law"—I noted that though cottage food laws are generally good, there are elements to nearly every cottage food law that leave much to be desired.

That's where the aforementioned recent improvements to a host of state laws come into play. Last week, for example, Illinois Gov. J.B. Pritzker became the latest state executive around the country to ratify improvements to a state's cottage food law. The updated Illinois law will expand the number and type of legal sales venues—which had been limited to farmers markets.

In Alabama, lawmakers recently amended the state's existing cottage food law to eliminate the state's low $20,000 sales cap for selling cottage foods, expand the list of foods that may be sold under the law, and lift a ban on online sales.  In Arkansas, lawmakers replaced much of the state's existing cottage food law, removing some licensing, inspection, and labeling requirements and adding more permissive language that allows the sale of more types of foods, along with additional sales venues.

Minnesota lawmakers raised that state's cap on cottage foods sales from $18,000 to $78,000, along with other changes. And Florida legislators lifted the cap on cottage foods sales there, too, boosting the limit from $50,000 to $250,000. The updated Florida law also greatly expands the type of sales venues and bars local governments and health departments—which often chafe at having to comply with state cottage food laws—from establishing stricter standards than those mandated statewide.

Several other states also updated their cottage food laws during their respective 2021 legislative sessions, including Indiana, New Mexico, Oklahoma, and Texas. Overall, while some of these updates added additional requirements—for example, Alabama's updated law requires nutrition information to be added to cottage food product labels—the general trend nationwide is to reduce the red tape cottage food producers face. That's a good thing!

"2021 has been an unprecedented year for the cottage food industry," says David Crabill, who runs the respected cottage food website Forrager.com, in an email to me this week. "2020 showed us why cottage food laws are so important to have, and as a result, over half of the states tried to improve their law this year. Going forward, we can expect even more states to jump on board by implementing good cottage food laws that give their citizens the freedom to start a food business more easily and earn income to support themselves and their families."

Rather than serving as an endpoint, lawmakers' recent improvements to cottage food laws around the country point to the need and capacity to continue to improve these laws. Notably, I'm currently working on a study for the Reason Foundation (the nonprofit that publishes Reason), tentatively titled Out of Your Kitchen, that compares state laws governing the sale of homemade foods. These include not just cottage food laws but also food freedom laws and what are known as microenterprise home kitchen ordinances. As the report will reveal, the best state laws governing the sale of homemade foods are the ones that contain the fewest and least onerous restrictions.

02 Jun 15:02

What Do Treatments For Accelerated Aging Tell Us About Normal Aging?

by Scott Alexander
Jack

Interesting

Progeria is a rare disease that makes people age unnaturally quickly. Babies born with progeria can lose their hair in toddlerhood, get wrinkles by grade school age, and die - apparently of old age - in their early teens. You can see a picture of a progeroid child here, though I don't recommend it.

There's been a lot of research on one important form - Hutchinson-Gilford Syndrome - and just last year, the FDA approved the first treatment, a drug called lornafarnib. In the study, a few hundred children averaging around 7 years old took the drug for two years; 3% died during that time. In an ad hoc group of untreated comparison children, about 30% died during the same period. I'm a little confused by the methodology - it seems like the "comparison children" were chosen partly because they died too early to get into the trial, which sounds like a pretty major confounder - but everyone seems to treat this as reasonable so I will assume they adjusted for this in some way. If that's true, then lornafarnib cuts mortality by 90%.

That's great for the 300 or so children worldwide with Hutchinson-Gilford progeria (it's a really rare disease). But none of the discussion about this answered the question I wanted to know: can lornafarnib also prevent normal aging?

After looking into this more, I find some evidence the the answer is no, but also some reasons why maybe it's less clear cut than that?

Hutchinson-Gilford progeria (I'll just say "progeria" from here on, even though that's kind of inaccurate) is what's called a laminopathy. It's a disease of the nuclear lamina, a weblike structure that helps support and give shape to the cell nucleus. The lamina is partly made of a protein called lamin A. Children with progeria have a mutation in the relevant gene; instead of producing lamin A, they produce a defective mutant protein called progerin. The cell tries to build the nuclear lamina out of defective progerin instead of normal lamin A, and as a result the cell nucleus is screwed up and can't maintain a normal shape.

So then aging happens? My sources don't seem to have a great explanation of this. The UniProt database says that this "acts to deregulate mitosis and DNA damage signaling, leading to premature cell death and senescence". This paper goes a little further, saying that the screwiness in the nuclear lamina prevents DNA repair proteins from doing their job.

Many different processes cause aging, but one of those processes is accumulation of DNA damage. Sometimes this makes cells do their jobs less well. Other times it shifts them into a state euphemistically termed "senescence", where they realize something is wrong, chemically "scream" for the immune system to come kill them, but the immune system is overtaxed and so they just sit there screaming out more and more chemicals and poisoning everything around them.

So a unified theory of progeria goes: the lamin mutation causes accumulation of defective protein in the nucleus, preventing DNA repair. This makes people accumulate DNA damage faster, and since DNA damage is a major cause of aging, it makes these people age more quickly.

Lornafarnib interferes with the production of the defective progerin protein. As best I can tell, it doesn't cause the cell to produce healthy lamin A - it just prevents the defective mutant version from accumulating. For whatever reason, the cells without lamin A do surprisingly okay as long as they don't have the defective mutant version. So this prevents most of the DNA repair problems, and so decreases premature aging.

All of this suggests lornafarnib shouldn't help prevent normal aging. After all, normal aging is caused by lots of processes including gradual expected accumulation of DNA damage - not just the downstream effects of one weird mutant protein.

...except that in doing this research I kept finding people saying that maybe some of aging is caused by this one weird mutant protein. I don't claim to fully understand Scaffidi and Misteli, but they write:

Age-related nuclear defects are caused by sporadic use, in healthy individuals, of the same cryptic splice site in lamin A whose constitutive activation causes [Hutchinson-Gilford progeria]. Inhibition of this splice site reverses the nuclear defects associated with aging. These observations implicate lamin A in physiological aging.

Musich and Zou write, in a way that doesn't quite let me trace back their reasoning:

It is quite likely that the same sporadic abnormal splicing of prelamin A mRNA is responsible for the genome instability in both HGPS and normal aging.

I don't really get what's going on here. I know that often, as age-related damage degrades DNA, a lot of weird malformed proteins pop up and accumulate - for example, the beta amyloid plaques that might (or might not) be involved in Alzheimers. Maybe progerin is one of these proteins and causes some of the problems commonly associated with aging? But what percent of the problems? If it and 99 other defective proteins each cause 1%, not really a big deal. If it's 50%, bigger deal - but nothing is ever that easy.

02 Jun 14:57

Moral Costs Of Chicken Vs. Beef

by Scott Alexander

I.

I've previously argued that meat-eaters concerned about animal welfare should try to eat beef, not chicken. The logic goes: the average cow is very big and makes 405,000 calories of beef. The average chicken is very small and makes 3000 calories of chicken. If you eat the US average of 250,000 calories of meat per year, you can either eat 0.5 cows, or 80 chickens. If each animal raised for meat experiences some suffering, eating chicken exposes 160x more animals to that suffering than eating beef.

Might cows be "more conscious" in a way that makes their suffering matter more than chickens? Hard to tell. But if we expect this to scale with neuron number, we find cows have 6x as many cortical neurons as chickens, and most people think of them as about 10x more morally valuable. If we massively round up and think of a cow as morally equivalent to 20 chickens, switching from an all-chicken diet to an all-beef diet saves 60 chicken-equivalents per year.

But some people have argued that we also need to consider global warming. Cows produce methane, which is a powerful greenhouse gas. Chickens don't. How does this affect the calculations?

According to Eshal et al 2014, chickens produce about 2 kg CO2 equivalent per 1000 calories of meat, and cows about 10 kg (here "CO2 equivalent" means a collection of greenhouse gases, especially methane, that produce as much global warming as that many kg CO2). Going back to the average person who eats 250,000 calories of meat per year, the person who eats all beef is producing 2500 kg CO2 per year; the person who eats all chicken is producing 500 kg.

How much does this change things? The average US citizen produces 17.5 tons of CO2 per year. Suppose this average person was originally eating half beef and half chicken, in which case they would get 1250 kg CO2 from beef + 250 kg from chicken = 1.4 tons from beef + 0.3 tons from chicken. That leaves 15.8 tons coming from other things like cars and plane flights.

So if this average person switched to eating only chicken, their yearly CO2 production would drop from 17.5 tons to 16.4 tons. If they switched to eating only beef, their yearly CO2 production would rise from 17.5 tons to 18.6 tons. So the CO2 difference between an all-beef and an all-chicken diet is 16.4 tons of CO2 yearly vs. 18.6 tons yearly, or about 10%.

So switching from all-chicken to all-beef saves about 60 chickens per year, at the cost of 2.2 tons extra CO2, a 10% increase in your yearly production.

Nobody agrees on exactly how much it costs to offset a ton of carbon. This site says "anywhere from $0.10 per tonne to $44.80 per tonne", but eventualy settles on $3.30. QZ says "between $4 and 13 per metric ton". Terrapass sells offsets for $10 a ton; let's stick with that for now, while admitting it's at best an order-of-magnitude estimate.

Offsetting the carbon cost of going from an all-chicken diet to an all-beef diet would cost $22 per year, or about 5 cents per beef-based meal. Since you would be saving 60 chickens, this is three chickens saved per dollar, or one chicken per thirty cents. A factory farmed chicken lives about thirty days, usually in extreme suffering. So if you value preventing one day of suffering by one chicken at one cent, this is a good deal.

II.

This is the simple version of this argument for public consumption. Everything below is optional and makes things much worse and more complicated without an obvious change in the conclusion.

It's unfair to compare direct action on animal suffering (in the form of eating beef rather than chicken) to offsets on global warming. What if we were to make the opposite comparison - direct action on global warming vs. offsets on animal suffering? IE you eat chicken because it's better for the planet than beef, then offset the costs with donations to effective animal charities.

How much does it cost to offset animal suffering by saving more animals from more suffering? Many charities have made claims about this, some more hyperbolic than others. I am not an expert in animal charity evaluation, and the people who are refuse to give numbers for this because they know that dumb people like me would interpret their wild guesses as gospel truth. But some good effective altruist organizations did some research that loosely suggests a cost of $6 to save one chicken.

So if you wanted to go from an all-beef diet to an all-chicken diet to prevent global warming, you could offset the 60 extra chickens by paying $360.

So imagine our standard American, eating half beef and half chicken. He might offset the cost of the chicken he eats with $180 to effective animal suffering charities, and offset the cost of the beef that he eats with $11 to effective carbon offset charities. If he wanted to switch to all-beef, he would owe an extra $11; all-chicken, an extra $180.

If you are actually doing the offsets, you should eat whatever you find most delicious, since it's morally neutral anyway. But what if you're not going to? Should you eat more beef, on the grounds that the market has priced its moral cost at lower than chicken's moral cost?

Imagine a world where Yog Sothoth was constantly devouring galaxies full of intelligent life forms, an atrocity beyond your ability to imagine. But there was a charity that could stop him at a cost of $1 per galaxy. But in practice, not very many people donated to this charity - or maybe lots of people donated to it, but Yog Sothoth is vast and devours far more galaxies than mere mortals have dollars, so many galaxies are getting devoured despite this very effective prevention strategy.

And imagine that every time you ate chicken for dinner, Yog Sothoth would devour an extra galaxy. We calculate it out and find that eating chicken only causes the equivalent of $1 in damage (since Yog Sothoth eats only one extra galaxy, and we can save one galaxy for a dollar). The implied moral is "Go ahead and eat chicken, it only does $1 worth of damage and that's not much". But actually, it causes an entire galaxy full of intelligent beings to die.

Now imagine that beef still causes global warming, and that you can offset the global warming caused by one beef dinner at $2 (real world prices are lower, but grant it for the sake of argument).

Someone thinks "I could eat chicken and offset it with $1, or I could eat beef and offset it with $2, I'm not actually going to do the offsetting, but the market has said chicken is less morally costly than beef". Then that person eats chicken and destroys a galaxy, when they could have eaten beef and produced a few extra pounds of carbon.

The moral of the story is: if there's some kind of weird market failure that causes galaxies to be priced at $1, normal reasoning stops working; things that do incalculable damage can be fairly described as "only doing $1 worth of damage", and you will do them even if less damaging options are available.

(it's still totally fair to eat chicken and donate $1 to the Stop Yog Sothoth Fund, it's just catastrophic if you abstract away the step where you donate the dollar)

Either carbon offsets, animal suffering offsets, or both could be market failures like this. In fact, if you believe that we're currently not doing enough to fight climate change or animal suffering, I think you almost have to believe there are market failures in offsets.

So all statements like "eating beef only causes 30 cents worth of damage" and "eating beef is cheaper to offset than eating chicken" have to be adjusted based on how bad a failure there is for beef and chicken offsets. Since we don't know these numbers, we should be wary of thinking the prices of either offset tell us very much.

But I would argue the balance is still in favor of eating beef over chicken. First, the offset cost of $10 per ton of carbon is pretty well-studied and probably order-of-magnitude right. The $6 per chicken cost is almost completely made up. While some would say this gives it an advantage (because it could be much better than this) I think the usual rule is that the more made-up a number is, the more likely it is to be skewed in favor of looking good. This should bias us against a strategy that relies on chicken offsets.

Second, most likely anything you personally do to prevent global warming won't matter at all; either very large-scale actors like states and corporations will fail and there will be various disasters, or the large-scale actors will succeed and we will escape most problems. Meanwhile, if you don't eat some chickens, those particular chickens don't get eaten. While I don't like thinking in these terms too much because it prohibits superrational coordination, I think it's fair to take them into account as a tiebreaker.

In conclusion, eating beef causes more climate change than eating chicken, but eating chicken causes more animal suffering than eating beef. Offsetting the climate change effects of beef would only cost $22 per year, which seems really good. Offsetting the animal suffering effects of chicken might only cost $360 per year, but this is a very tentative estimate and maybe shouldn't be taken seriously. Also, these only work if you're actually doing the offsetting. If not, you should probably default to eating beef over chicken, but I can't prove it.

28 May 03:53

Put Anthony Fauci in a Dunk Tank

by Conor Friedersdorf

Updated at 5:55 p.m. ET on May 14, 2021.

Imagine a Fourth of July 2021 celebration at the White House. America has reached its vaccination goals. A jubilant President Joe Biden rips off his mask, douses it in lighter fluid, and tosses it on a charcoal grill, where it burns for the news cameras. Late afternoon turns to early evening, with the promise of fireworks ahead, but before then, Anthony Fauci, outfitted in goggles and a vintage one-piece, red-white-and-blue-striped bathing suit, climbs into a dunk tank filled with Bud Light. He’s making good on a promise to get dunked on Independence Day if, and only if, 75 percent of Americans have received at least one COVID-19 shot. Joe Rogan strides out, a big bucket of baseballs in hand.

Meanwhile, in all 50 states, free Fourth of July concerts featuring the biggest acts in the nation are playing in front of 100 percent–vaccinated crowds; many got jabs just so they could attend. Beyoncé slays in Atlanta. Luke Combs rocks Nashville. Bad Bunny plays San Juan.

Roughly 43 percent of American adults have yet to receive a COVID-19 vaccine, but demand for shots is already falling, with some states cutting back on the number of doses that they are requesting for their residents.*

[Derek Thompson: 3 explanations for the vaccine slowdown]

Most of the official responses to this problem have been tepid. “Clergy can play a great role as well as your own family doc,” Fauci told an interviewer this week, “because most people really trust a doctor that’s been taking care of their family for a long time.” California is running public-service announcements.

Boring!

Don’t blame the public-health officials. They are who they are. But with every passing day, their instincts will yield diminishing returns: The Americans they are best suited to reach have already been vaccinated. Cold, hard cash would sway some of the rest. In a UCLA survey, a third of unvaccinated Americans said they would be more likely to get a shot for $100. That’s a bargain.

And in my estimation, a cash-for-shots program would be powerfully complemented by a three-legged stool of free beer, free bacon, and free lottery tickets in exchange for getting two shots of Pfizer or Moderna or the Johnson & Johnson one-shot. Don’t woo Americans with mere common sense or cash, but with spectacle.

This approach will horrify many a county-health official. I beg them to wring their hands. My targets will revel in whatever irks these bureaucrats, because they view them as smarmy scolds. “Smarm is a kind of performance—an assumption of the forms of seriousness, of virtue, of constructiveness, without the substance,” Tom Scocca wrote in a 2013 Gawker essay. “Smarm is concerned with appropriateness and with tone. Smarm disapproves.” America needs to reach the subset of its residents who’ve found pandemic messaging to be off-puttingly smarmy.

A small experiment in free beer is already showing promise. In Buffalo, New York, a local brewery offered a pint to anyone who came in for a first shot and ultimately distributed vaccines to more people in a single day than all of the Erie County clinics had, combined, the prior week. If I have any criticism of the effort, it’s the open enthusiasm of the public-health officials. Grudging acquiescence might be more effective.

The typical American has a sense that public-health types want them to eat less salty, fatty processed meat. How powerful, then, if the message from the most dour public-health bureaucrat in each city was “I’m loath to think of you eating a Baconator at Wendy’s, but getting a COVID-19 vaccine is so important that we’ll give you a coupon for a free one if you get your jab before July 4.”

At the Heart Attack Grill in Las Vegas, customers weighing more than 350 pounds eat free and menu items include the Octuple Bypass Burger, which has almost 20,000 calories.** If I were the face of public health in Clark County, I’d be on the local evening news with a representative of the Heart Attack Grill telling him that his establishment embodies everything I find repellent ... but that if Vegas gets to 85 percent vaccinated, I’ll order and eat the Octuple Bypass.

Free lottery tickets may hold the most promise of all. Vaccine hesitancy and lottery enthusiasm are two sides of the same disregard for statistics. How better to reach people unswayed by expert advice on what is statistically likely to serve their interests than to offer a minuscule chance at $100 million? Forty-five states, plus the District of Columbia, Puerto Rico, and the U.S. Virgin Islands, already run lotteries. Printing more tickets is basically free. And unlike every other state-lottery initiative, giving free tickets for getting vaccinated would actually leave most participants better off.

[Juliette Kayyem: Don’t want for herd immunity]

In fact, Ohio Governor Mike DeWine is putting this idea into practice: This week he announced a spate of million-dollar lottery drawings for anyone in the state who has received at least one vaccine dose. Winners should be feted to spark interest in another round.

The pandemic has been a dismal slog. For many, a more appealing message than “Get the vaccine to protect your neighbors” is “We’re almost there—get this vaccine and you can have the biggest party in a generation.” And no one throwing a party entrusts planning to public-health officials. Populist politicians need to step up.

Cash. Beer. Bacon. Lottery tickets. And the promise of Fauci in the dunk tank. That’s all it would take. I can see it so clearly. Pandemic Victory Day would be both a celebration and a spur to additional shots, harnessing vulgar populism to help America surprise the world with its 90-plus percent vaccination rate, even as it exports greater numbers of doses daily to poorer countries in need of help.

By embracing that which they find distasteful, elites can prove that they aren’t just virtue signaling. This really matters.


*This article previously misstated that 43 percent of all Americans have yet to receive a COVID-19 vaccine. In fact, 43 percent of American adults have yet to receive a shot.

**This article mistakenly referred to the Octuple Bypass Burger as the Quintuple Bypass Burger.

27 May 18:05

San Francisco fact of the day

by Tyler Cowen

At a board of supervisors hearing last week, representatives from Walgreens said that thefts at its stores in San Francisco were four times the chain’s national average, and that it had closed 17 stores, largely because the scale of thefts had made business untenable.

Brendan Dugan, the director of the retail crime division at CVS Health, called San Francisco “one of the epicenters of organized retail crime” and said employees were instructed not to pursue suspected thieves because encounters had become too dangerous.

“We’ve had incidents where our security officers are assaulted on a pretty regular basis in San Francisco,” Dugan said.

And yes incentives matter:

The retail executives and police officers emphasized the role of organized crime in the thefts. And they told the supervisors that Proposition 47, the 2014 ballot measure that reclassified nonviolent thefts as misdemeanors if the stolen goods are worth less than $950, had emboldened thieves.

Here is more from the NYT, via Ilya Novak.

The post San Francisco fact of the day appeared first on Marginal REVOLUTION.

27 May 18:01

Cold Storage No Longer a Constraint

by Alex Tabarrok

Yahoo: With little fanfare, the U.S. Food and Drug Administration gave Pfizer permission this week to store its COVID-19 vaccine in a typical refrigerator for one month — freeing the vaccine from the need to be shipped in cumbersome boxes stuffed with dry ice.

Among authorized COVID-19 vaccines, Pfizer’s vaccine was notorious for its ultra-cold storage requirements. Now, as the only vaccine authorized for children ages 12 to 17, this new flexibility could dramatically accelerate the effort to vaccinate America’s teens and adolescents.

Pfizer spent millions on its cold storage technology and now discovers that it isn’t strictly necessary–that wasn’t a mistake, Pfizer did the right thing–but it’s a good reminder of how new this technology is and also how the clinical trial decisions are not written in stone.

Straussian take: Investigate fractional dosing.

The post Cold Storage No Longer a Constraint appeared first on Marginal REVOLUTION.

27 May 17:50

Modal markets in everything

by Tyler Cowen

… a substantial share of Americans express readiness to sell their votes for cash: 12% of respondents would do so for just $25, as would nearly 20% for $100. Citizens who place low importance on living in a democracy are significantly more willing to sell their votes…

From Jordan Gans-Morse and Simeon Nichter, via the excellent Kevin Lewis.

The post Modal markets in everything appeared first on Marginal REVOLUTION.

27 May 17:35

The new cold war with China

by ssumner
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Having lived through the Gulf of Tonkin incident, the ridiculous hysteria over Japan during the 1980s, and the post 9/11 hysteria over Iraq, I am dismayed by the bipartisan attempt to gin up a cold war with China. Especially given that Russia is a far greater threat. It has far more nukes, and it seized the Crimea from Ukraine.

Thus it’s nice to see a few thoughtful observors pushing back on the cold war narrative. Peter Beinart has a WaPo piece entitled “Biden’s Taiwan Policy Is Truly, Deeply Reckless“:

By keeping U.S. relations with Taiwan unofficial, the “one China” fiction helped Beijing imagine that peaceful reunification remained possible. Which gave it an excuse not to invade.

Like the Trump administration before it, the Biden team is now progressively chipping away at this bargain. Last summer, Democrats removed the phrase “one China” from their platform. . . .

What’s crucial is that the Taiwanese people preserve their individual freedom and the planet does not endure a third world war. The best way for the United States to pursue those goals is by maintaining America’s military support for Taiwan while also maintaining the “one China” framework that for more than four decades has helped keep the peace in one of the most dangerous places on earth.

Hawks will call this appeasement. So be it. Ask them how many American lives they’re willing to risk so the United States can have official diplomatic relations with Taiwan.

The FT warns that the US military industrial establishment is playing a dangerous game:

Chinese military aircraft are flying into Taiwan’s air defence identification zone on an almost daily basis now, and those flights are increasing in both frequency and range.

But rather than a step towards war, these moves are more likely to be part of a campaign to intimidate Taiwan with so-called grey-zone tactics. Constant fear-mongering over the risk of a Taiwan war only plays into the hands of such a Chinese strategy.

Some security experts see the US Indo-Pacific Command’s warnings of a heightened war risk as an attempt to secure budget funds for propping up the US military presence in the region, as well as to influence the Biden administration’s China policy review.

“This is a defence-driven assessment in the US,” rather than a systemic analysis of Chinese interests in the region, said Bonnie Glaser, a veteran China expert at the German Marshall Fund of the US.* “They have really done a disservice to American national interests.”

The Economist warns of a groupthink on the issue:

“It doesn’t take any bravery to be a China hawk today. It takes bravery to not be one,” says a former official who advised several presidents on China. He and many others see a desire for a new cold war in Washington. . . .

Expertise about China is not necessary. Within government, analysts who once focused on war zones have pivoted to China. Those who preach moderation towards the Chinese government risk being tarred by the most strident hawks as apologists, their motives called into question. Esteemed China specialists who were previously called on by the White House for advice have fallen out of favour.

Commenters on this blog also question my motives.

In Australia, it’s even worse:

The government of Scott Morrison, prime minister since 2018, relishes calling China out. By now, though, the rhetorical flourishes are starting to sound as though it were girding for war. Mr Morrison says Australia must speak with “one voice” on foreign policy, as if scrappy debate was uncalled for, or even unpatriotic. . . .

One veteran Canberra hand describes a dangerous “ideological intolerance” in which moderate voices are drowned out and the debate about China is reduced to emotion. Another senator, Eric Abetz, last year even called on Chinese-Australians appearing before his committee to denounce the Communist Party. That points to a further risk, says Greg Barns, a lawyer: pinko paranoia plays to a xenophobic, racist undercurrent that has long run through Australian life.

Such an undercurrent risks resurfacing if Chinese-Australians face questions or abuse about their loyalty. If the hawks’ tactics end up making Australia seem a less civil, tolerant or welcoming place, then the country will be the poorer for it.

Is China trying to take over the world? You be the judge:

China has blamed the abrupt US withdrawal of forces from Afghanistan for a surge in attacks, after multiple explosions at a girls’ school in Kabul on Saturday killed more than 60 people, most of them female students.

Foreign ministry spokeswoman Hua Chunying said China was “shocked” by the attacks and “deeply saddened” by the death toll. She also called on Washington to pull out troops “in a responsible manner”.

Here’s a question for those of you who think China’s just like the old Soviet Union. Would the Russians have complained about the US withdrawing troops from a country right on the Soviet Union’s southern border?

PS. Speaking of China, the new census showed a huge imbalance in population growth, with some provinces losing population and others growing rapidly. I notice that most of China’s population growth occurred in 4 provinces (Guangdong, Zhejiang, Jiangsu and Fujian.) Those also happen to be China’s most market-oriented economies. It seems like the Chinese people are moving toward capitalism. Perhaps they don’t agree with Western pundits who attribute China’s success to statist economic policies. In contrast, China’s most statist provinces (in the northeast) all lost population–even the one on the coast.

PPS. Sometime this year, Guangdong province will surpass Japan in population.

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27 May 06:16

Freddie deBoer: Let's Kill the 'Cult of Smart' and Legacy Media

by Nick Gillespie
Jack

Interesting perspective

freddied5

Born in 1981, Freddie deBoer is an English Ph.D., the author of The Cult of Smart: How Our Broken Education System Perpetuates Social Injustice, and the proprietor of one of the liveliest, most provocative, and most controversial publications at Substack.

He is also a third-generation Marxist who believes that individuals are innately different from one another (probably due to inherited differences in intelligence and physical capacity) and that many of his fellow Bernie Sanders-loving, progressive inhabitants of Brooklyn are hurting the poor when they insist that all K-12 students take college prep classes and have access to higher education. "Education is not a weapon against inequality; it is an engine of inequality," he writes, sounding like Dirty Jobs' Mike Rowe when it comes to promoting well-paying but low-status trade jobs. What deBoer calls "the cult of smart"—the valorization of test-taking and a belief that all of us are blank slates who can be remediated through the right sort of instruction and environment—not only marginalizes the poor and "untalented," it ultimately blames them for their own condition.

His take on legacy media is equally acid, as when he tells critics of Substack, the controversial newsletter platform that has given a financially rewarding home to him and other writers who either left or never gained purchase at traditional journalistic outlets, "You don't like the writing that gets sold on Substack, cool, write better shit and sell it to more people."

Nick Gillespie talks with deBoer about his critiques of education, the mainstream media, and the contemporary left. They also wrangle over deBoer's call for "revolution, not evolution" and an end to capitalism, what it means to "want to live outside of exchange," and the surprising overlap between Marxists and libertarians when it comes to a range of current policy issues.

27 May 04:52

The media's lab leak fiasco

by Matthew Yglesias
Jack

Depressingly familiar

As I believe I have said before, I spent the month of February 2020 intensely focused on covering the seemingly imminent victory of Bernie Sanders in the Democratic Party’s presidential primary. I dedicated approximately 0% of my journalistic energy to covering what was, in retrospect, the clearly more significant story of a novel coronavirus outbreak starting in Wuhan, China and clearly spreading to other parts of the world.

I was aware of the virus in much the way that I am aware of the National Hockey League, but I wasn’t paying attention to it as a journalist. The first piece I published on Covid on March 12 holds up pretty well I think, but it was way too late in terms of the kind of tough travel restrictions that, in retrospect, the country needed.

Due to not paying any attention, I missed the furious initial skirmish in what’s become the Long Discourse Wars over the idea that the SARS-CoV-2 virus came from the Wuhan Institute of Virology rather than originating naturally in bats.

What happened is that Tom Cotton raised this idea in February in his capacity as a China hawk, and then again in March as part of a nonsensical attack on Joe Biden. He got shouted down pretty hard by scientists on Twitter, by formal institutions, and by the media. Then this kind of pachinkoed down into being a politics story where writers and fact-checkers who didn’t cover science at all “knew” that this was a debunked story that right-wingers were pushing for their nefarious ends. I think it’s increasingly clear that this was a huge fiasco for the mainstream press that got way over their skis in terms of discourse-policing, and there is in fact a serious scientific question as to where the virus came from — a question that we will probably never be able to answer because the Chinese government has clearly committed to one viewpoint on this and isn’t going to allow a thorough investigation.

A separate question that’s less clear to me is what follows from this in terms of policy. You can break this down into three questions:

  • Suppose the media had been more open to Cotton’s point back in February 2020 — what would we have done differently?

  • Suppose definitive evidence arises this Friday that the virus in some sense came from the Chinese lab — what would we do differently going forward?

  • Or suppose definitive vindication of the zoonotic origin theory emerges — what difference would that make?

I think in all three of these cases, the answer is basically that nothing would be different. This is not to apologize for the bad coverage but, if anything, to underscore how egregious it was to lean so heavily into the Tom Cotton Is Wrong narrative. The subsidiary premise of that narrative was always that Cotton was doing something extremely nefarious. But while Cotton does indeed have a lot of opinions I disagree with, it’s just not true that this lab leak idea is now or ever was very closely linked to any hot-button policy controversies.

The situation in January 2020

Looking back on the media fiasco side of this, it seems to trace back to statements Cotton made at a Senate Armed Services Committee hearing on January 30. This appears to have been a hearing with senior military commanders from U.S. Africa Command and U.S. Southern Command. I think talking about a virus outbreak in China probably sounded like a bit of a crank thing to do, but Senators say weird stuff at hearings all the time.

Cotton said that the Chinese government had been lying about the severity of the outbreak all month and that their story linking the outbreak to the Huanan Wholesale Seafood Market was dubious.

Cotton’s remarks were not widely covered at the time, but this basic claim seems to me to have been well within the range of establishment consensus views.

He was referring to an article in the Lancet, a very establishment publication. Max Fisher at The New York Times used that same Lancet article to do a piece arguing that the virus situation in Wuhan illustrated the flaws in China’s authoritarian governance model — that local officials would not circulate “bad news” if it would be seen as unwelcome to top leaders.

Julia Belluz at Vox did a piece about the Lancet study and a few other pieces of evidence that Chinese leaders weren’t telling the truth.

“These discrepancies add new urgency to a question many are already asking,” she wrote. “Did China downplay the outbreak early on? And if so, why?”

Her article surveys various experts and moots several theories, including Fisher’s. But she also raises Cotton’s argument that this was perhaps deliberate malfeasance:

A third explanation is that China was purposely playing down the health emergency, as it did during the SARS outbreak of 2003. Back then, China was heavily criticized for reacting slowly, withholding information about the outbreak for too long, and putting economic considerations ahead of public health. The virus eventually killed 774 people and infected more than 8,000. 

“The fact that the Lancet report is different from the official early Chinese account does raise enormous concerns around the truthfulness of information coming out of China,” said Steven Hoffman, director of the Global Strategy Lab and a global health professor at York University. “If China did intentionally withhold information, that would not only be bad for public health but also illegal under international law. It would be a violation of the International Health Regulations, a legally binding treaty that covers how 195 countries respond to outbreaks like this one.” 

The Lancet piece came out on January 24. Fisher wrote on January 25. On January 26, a piece in Science ran that was titled “Wuhan seafood market may not be source of novel virus spreading globally.” Belluz wrote on January 27, and Cotton spoke and Tweeted on January 30.

But Cotton did one thing that those other sources didn’t do — he speculated a little. At the end of that clip he says “we still don’t know where coronavirus originated. Could have been a market, a farm, a food processing company. I would note that Wuhan has China’s only biosafety level-four super laboratory that works with the world’s most deadly pathogens to include, yes, coronavirus.”

That is all not only true, but entirely consistent with what mainstream media was reporting at the time. But then things went horribly off the rails.

February 2020, inventing a “conspiracy”

Cotton’s statements did not get any immediate coverage, but several days later David Choi at Business Insider wrote them up with the headline “Republican senator suggests ‘worse than Chernobyl’ coronavirus could've come from Chinese ‘superlaboratory.’”

Choi’s piece is one of those things that happens on the internet when the story is totally accurate but also doing a lot of sensationalization for clicks. What Cotton said at the hearing is that the Chinese government’s official story about the seafood market was wrong, which was something that was at the time also being floated in Vox and The New York Times and Science and the Lancet. Where Cotton differed from the consensus is that he attributed this to malice, which is not what the scientific articles said (but also isn’t a scientific question) and was not the NYT’s preferred interpretation of events.

But that was the actual parameter of the debate; Fisher thought this illustrated a point about the abstract functioning of systems while Cotton thought it illustrated a point about the malign intent of a foreign adversary. Belluz, a science journalist rather than a foreign policy writer, entertained both interpretations as consistent with the facts. And it seemed like a fairly classic foreign policy sort of argument. Throughout history, hawks see malice and threat behind everything that happens, while more dovish people tend to see misunderstanding and confusion. You can imagine the Tom Cotton of 1914 talking somewhere in Vienna about the Serbian government’s obvious complicity in the assassination of Franz Ferdinand while the Max Fisher of the time says the difficulty controlling the Black Hand and its operations reveals the fundamental weakness of the Serbian state.

What Choi did was not exactly accusing Cotton of spreading a conspiracy theory about Chinese bioweapons, but just sort of locating his remarks as adjacent to other people’s conspiracy theories and misinformation:

Cotton was referring to China's first Biosafety Level 4 lab, the Wuhan National Biosafety Laboratory of the Chinese Academy of Sciences, which investigates “the most dangerous pathogens,” according to the US Centers for Disease Control and Prevention.

While Cotton qualified his remarks by saying “we still don't know where” the virus originated, his comments come amid numerous conspiracy theories about the virus's origins — including one that says the virus “originated in lab linked to China's biowarfare program.”

The amount of false information spreading across social-media platforms has prompted several companies, including Facebook, to limit the reach of such posts. In a statement, Facebook said it would display “accurate information” and notify users if they are suspected of sharing false or misleading information.

So now we have leaped from “everyone agrees the Chinese government’s claims were wrong but Cotton is an outlier in claiming they were deliberately wrong” to “Cotton’s views should be associated with conspiracy theories and misinformation,” even though his core factual claim was not particularly different from what anyone was else was saying. Then things blew up, thanks not so much to a Sunday show interview as to tweets about an interview.

“Rumors about a Chinese bioweapon”

On February 9, Margaret Brennan interviewed China’s ambassador to the United States, Cui Tiankai, about the virus outbreak. During the course of the interview, she said to the Ambassador that Cotton “suggested that the virus may have come from China’s biological warfare program — that’s an extraordinary charge, how do you respond to that?”

I’m not sure that’s really the best characterization of what Cotton said, but it’s not wildly wrong either.

And Cui’s reply was pretty restrained and honestly very diplomatic considering that Cotton is a big hawk and China’s propaganda messaging is often heavy-handed and clumsy.

I think it’s true that a lot is still unknown and our scientists — Chinese scientists, American scientists, scientists of other countries — are doing their best to learn more about the virus. But it’s very harmful, it’s very dangerous to stir up suspicion, rumors and spread them among the people. For one thing, this will create panic. Another thing is that it will send up racial discrimination, xenophobia, all these things that will really harm our joint efforts to combat the virus. Of course, there are all kinds of speculation and rumors. There are people who are saying that this virus are coming from some military lab [sic] — not of China, maybe in the United States. How can we believe all these crazy things?

Then Brennan asks him squarely “where did the virus come from?” to which Cui responds, “We still don’t know yet, it’s probably — according to some initial outcome of the research — probably coming from some animals, but we have to discover more about it.”

So at this point, Cui’s official position is that we don’t know where the virus came from, but it was probably an animal. And Cotton’s position is that we don’t know where the virus came from, but it might have been the lab. Cui says it is irresponsible to speculate about the lab, while Cotton says the speculation is good. Cotton is not, I think, saying the virus was Chinese biowarfare — he is saying the PRC is not trustworthy. The PRC ambassador’s position, obviously, is that he is in fact trustworthy.

But whoever writes up the exchange for the Face The Nation Twitter account goes with Cui “dismisses #coronavirus conspiracy theories pushed by @SenTomCotton that it’s being used as biological warfare as ‘absolutely crazy.’”

It seems to me that Cotton did not say the virus was being used as biological warfare.

But Cotton’s Twitter account fired back.

Cotton doubled-down on the idea that China “lied” (as opposed to was just wrong) because he’s a China hawk and he pressed for more openness “to competent international scientists.”

Politico then wrote up the interview (but really the tweets rather than the actual interview) in fairly sensationalistic terms, saying that “when asked about comments made last week by Sen. Tom Cotton (R-Ark.) — who, according to Brennan, suggested the virus may have come from China’s biological warfare program — Cui did not mince words” then quoting the part of Cui’s statement that started with “it’s very harmful.”

I have to insist, though, that Cui really was kind of mincing words. If you watch the video, there is no epic slam on Tom Cotton — he is deflecting diplomatically.

But then Blake Hounshell from Politico tweeted about the article about the tweets about the interview, calling it “wild” that Cotton was “spreading rumors about a Chinese bioweapon,” which just didn’t happen.

At this point, Cotton had achieved what’s really the greatest achievement possible for a Republican Party politician — he was unfairly maligned by the MSM.

The “debunked” “fringe theory”

I think it’s important to remember that at this point in American history, the Covid issue was not polarized the way that it is today.

On January 27, Joe Biden published a USA Today op-ed calling the outbreak a major crisis, but his presidential campaign seemed to be on the ropes at the time.

By contrast, Trump’s message was that everything was fine thanks to his confidence in the Chinese government:

  • 2/7 Tweet: “Great discipline is taking place in China, as President Xi strongly leads what will be a very successful operation. We are working closely with China to help!”

  • 2/7 remarks: “I had a great conversation last night with President Xi. It's a tough situation. I think they're doing a very good job.”

  • 2/10 Fox Business interview: “I think China is very, you know, professionally run in the sense that they have everything under control.”

  • 2/10 campaign rally: “I spoke with President Xi, and they’re working very, very hard. And I think it’s all going to work out fine.”

  • 2/13 Fox News: “I think they've handled it professionally and I think they're extremely capable and I think President Xi is extremely capable and I hope that it's going to be resolved.”

That’s the context for Cotton’s February 16 appearance on Maria Bartiromo’s Fox show.

Cotton does not believe that it’s all going to work out fine, that the Chinese have everything under control, or that President Xi is worthy of all this praise. He thinks that Biden is right and the outbreak is a very serious problem. Cotton is going on television mostly to do the “Audience of One” thing where, because Trump doesn’t read briefing documents, the best way to persuade him of something is to go on television. And because the conservative movement is totally dysfunctional in terms of its relationship to Trump, Cotton does not say squarely that Trump is wrong. Instead, he gushes with praise for Trump’s restrictions on flights from China but says we should do even more. And he emphasizes that the Chinese government is not trustworthy — though again totally leaving out how gullible and obsequious Trump is being.

Here’s what Cotton says in the interview specifically about the lab:

Here’s what we do know: this virus did not originate in the Wuhan animal market…So we don’t know where it originated, but we do know that we have to get to the bottom of that. We also know that just a few miles away from that food market is China’s only biosafety level 4 super laboratory that researches human infectious diseases. Now, we don’t have evidence that this disease originated there, but because of China’s duplicity and dishonesty from the beginning, we need to at least ask the question to see what the evidence says. And China right now is not giving any evidence on that question at all.

This is provocative, but not so different from what Joe Biden (who, again, at this point was the enemy progressives were trying to beat in a primary) would say 10 days later:

What I would do were I president now, I would not be taking China’s word for it. I would insist that China allow our scientists in to make a hard determination of how it started, where it’s from, how far along it is. Because that is not happening now.

But while Biden’s remarks were mostly ignored, Cotton’s caused several prominent media outlets to fly off the handle.

Paulina Firozi at the Washington Post wrote a story headlined “Tom Cotton keeps repeating a coronavirus conspiracy theory that was already debunked.”

But the theory Firozi cites as being debunked is the theory that the virus was deliberately engineered as a weapon. That’s not what Cotton said, and indeed the text of her story seems to acknowledge that he didn’t say that.

Yet Cotton acknowledged there is no evidence that the disease originated at the lab. Instead, he suggested it’s necessary to ask Chinese authorities about the possibility, fanning the embers of a conspiracy theory that has been repeatedly debunked by experts.

A similar piece by Alexandra Stevenson in the New York Times is headlined “Senator Tom Cotton Repeats Fringe Theory of Coronavirus Origins.”

But again, the article is overwhelmingly about people who are not Tom Cotton saying something different from what Tom Cotton said. Stevenson’s piece is also a reminder that this was a different era of Covid politics, because one of the reasons she gives for doubting that it’s a deliberately engineered bioweapon (which again, is not what Cotton said) is that the virus isn’t really that big of a deal because younger and healthier people don’t have much to fear from it.

Although much remains unknown about the coronavirus, experts generally dismiss the idea that it was created by human hands. Scientists who have studied the coronavirus say it resembles SARS and other viruses that come from bats. While contagious, so far it appears to largely threaten the lives of older people with chronic health issues, making it a less-than-effective bioweapon.

Within a month or two, of course, the Covid discourse would become the subject of partisan polarization and this media critique of Cotton would become the consensus Republican view — Covid was no big deal.

Checking fake facts

Cotton essentially failed in his effort to persuade Trump, and as far as I can tell assimilated himself to the emerging GOP consensus that a few hundred thousand dead here and there is not a huge problem.

Meanwhile, the conventional wisdom of the media shifted in the opposite direction — that the pandemic was a really big deal and people should take stern countermeasures against it. At the same time, the “fact check” complex started taking an increasingly hard line against laboratory origin theories that it claimed had been debunked by scientists.

Among actual scientists, it is much less clear to me what the conventional wisdom ever actually ways. Politifact’s now-retracted fact check deeming lab leak theorists to have their “pants on fire” ran in September 2020. Also in September of 2020, Boston magazine ran a profile of Alina Chan, a molecular biologist at the Harvard-MIT Broad Institute, who believes the virus escaped from the biolab in Wuhan. It’s clear from the article that while Chan perhaps had a minority viewpoint, this was the kind of thing that was the subject of ongoing disagreement among researchers. And the main thing about it, as best I can tell, is that we just have a long history of viruses crossing from animals to humans so virologists’ baseline belief about a new virus is going to be that it came from animals.

When New York Magazine ran its lab leak theory story in January 2021, I tweeted disparaging things about it only to be told quietly by a number of research scientists that I was wrong and plenty of people in the science community thought this was plausible.

By March, Biden was in office and his team was arguing that China was not being sufficiently forthcoming about the origin of the virus. In May, a distinguished group of scientists called for a more rigorous inquiry.

Because there is obviously a big media fuckup angle to this story, the two biggest deal accounts for a lot of media-skeptics are Donald McNeil making the case for a lab leak and Nicholas Wade making the case for a lab leak because those are both veteran science reporters who got “cancelled.” But I do think it’s important to try to understand exactly who got what wrong here. My best assessment is to agree with Josh Rogin that this is a case of a smallish group of reporters and fact-checkers proclaiming a scientific consensus where none ever really existed.

There’s a question as to why that fake consensus emerged. But I think the more troubling question is: How did people let the original story of what Tom Cotton even said go so badly awry? Essentially Cotton said something that was then transformed into a fake claim of a Chinese bio-attack, then the fake claim was debunked, and then the debunking was applied to the real claim with little attention paid to ongoing disagreement among researchers.

What is actually at stake here?

Beyond the genuinely catastrophic media fuckup, the actual policy stakes in this controversy are less clear to me.

On Monday, I wrote that alcohol taxes should be raised, citing research about crime and liver disease. If new research emerged indicating that alcohol was more or less harmful than I previously thought, I would revise my estimate of the optimal alcohol tax.

By contrast, the stakes in the lab leak fight seem to be political. In 2014, Olga Khazan wrote an Atlantic article calling for stricter curbs on “gain of function” research at labs. Kelsey Piper wrote an article with a similar thesis in 2019 for Vox. If people believe the lab leak is true, that will bolster their case rhetorically. But I found Kelsey’s article persuasive when she wrote it — and I will continue to think she’s correct even if lab leak theory is eventually debunked.

Then there’s China policy. Cotton is a huge foreign policy hawk. Former Secretary of State Mike Pompeo is a lab leak fan and also a big foreign policy hawk. Lab leak theory could bolster anti-China politics. That being said, even if lab leak is false, it’s not that hard to find evidence for the proposition that the PRC regime is bad. They crushed Hong Kong. They’re running concentration camps in Xinjiang. My position on China is we need “One Billion Americans” in order to stay number one forever, and I’m not going to change that view. Rand Paul says this whole episode proves that Dr. Fauci is bad, but again, that’s what he already believed.

I hope the prior zillion words establish that I’m not trying to be an apologist for the bad media coverage of this issue. But there is a difference between a factual controversy where a change in facts affects people’s views and a factual controversy that is mostly about raising or lowering the status of different people and arguments. And this, I think, is a case of the latter. Evidence in favor of leak theory lowers the status of the media and raises the status of Tom Cotton but doesn’t drastically alter the policy landscape.

The perils of Twitter

Beyond the gross irresponsibility of the earliest media coverage, I think the story of Dr. Chan and her struggle to be heard illustrates the perils of expert dialogue on social media.

Social media is truly social in the sense that it features incredible pressures to form in-groups and out-groups and then to conform to your in-group. Unless you like and admire Cotton and Pompeo and want to be known to the world as a follower of Cotton-Pompeo Thought, it is not very compelling to speak up in favor of a minority viewpoint among scientists. Why spend your day in nasty fights on Twitter when you could be doing science? Then if you secure your impression of what “the scientists” think about something from scanning Twitter, you will perceive a consensus that is not really there. If something is a 70-30 issue but the 30 are keeping their heads down, it can look like a 98-2 issue.

I do not know a lot about science, so I will not opine how generally true this may or may not be.

But in economics, which I do know well, I think it’s a big issue. If someone tweets something you agree with, it is easy to bless it with an RT or a little heart. To take issue with it is to start a fight. And conversely, it’s much more pleasant to do a tweet that is greeted with lots of RTs and little hearts rather than one that starts fights. So I know from talking to econ PhD-havers that almost everyone is disproportionately avoiding statements they believe to be locally unpopular in their community. There is just more disagreement and dissension than you would know unless you took the time to reach out to people and speak to them in a more relaxed way.

My strong suspicion is that this is true across domains of expertise, and is creating a lot of bubbles of fake consensus that can become very misleading. And I don’t have a solution.

11 May 05:03

A Phase 3 Clinical Trial Confirms MDMA's Effectiveness As a Psychotherapeutic Catalyst

by Jacob Sullum
MDMA-capsules-MAPS

MDMA-assisted psychotherapy for people with post-traumatic stress disorder (PTSD) is substantially more effective than psychotherapy alone, according to a study reported today in Nature Medicine. The results of the Phase 3 clinical trial, which are consistent with earlier research, mean that MDMA, which was banned in 1985, is on track to be approved as a prescription drug by the Food and Drug Administration (FDA) as soon as 2023.

"These data indicate that, compared with manualized therapy with inactive placebo, MDMA-assisted therapy is highly efficacious in individuals with severe PTSD, and treatment is safe and well-tolerated, even in those with comorbidities," say University of California, San Francisco, neuroscientist Jennifer Mitchell and her co-authors. "We conclude that MDMA-assisted therapy represents a potential breakthrough treatment that merits expedited clinical evaluation."

The FDA officially recognized MDMA as a "breakthrough therapy" in 2017, meaning it "may demonstrate substantial improvement over existing therapies on one or more clinically significant endpoints." That designation signaled that the FDA would expedite development and approval of MDMA.

The double-blind, placebo-controlled trial, which was sponsored by the Multidisciplinary Association for Psychedelic Studies (MAPS), confirms MDMA's potential. The study included 90 subjects with "severe" PTSD who were randomly assigned to receive either MDMA or a placebo on three occasions. All of them participated in three preparatory sessions and nine "integrative therapy sessions."

In the MDMA group, scores on the Clinician-Administered PTSD Scale for DSM-5 had fallen by an average of 24.4 points 18 weeks after the study began, compared to 13.9 points in the placebo group. "Functional impairment" based on the Sheehan Disability Scale fell by an average of more than three points in the MDMA group and two points in the placebo group. The subjects who received MDMA also showed bigger improvements in mood as measured by the Beck Depression Inventory II. Their scores dropped by an average of nearly 20 points, compared to about 11 points in the placebo group.

"Three doses of MDMA given in conjunction with manualized therapy over the course of 18 weeks results in a significant and robust attenuation of PTSD symptoms and functional impairment," Mitchell et al. note. "MDMA also significantly mitigated depressive symptoms."

These results are striking but not surprising; psychotherapists have long observed similar effects. As the authors of an earlier MAPS-sponsored study put it, MDMA-assisted therapy is "aimed at allowing participants to revisit traumatic experiences while staying emotionally engaged even during intense feelings of anxiety, pain, or grief without feeling overwhelmed."

Mitchell et al. suggest that "MDMA may exert its therapeutic effects through a well-conserved mechanism of amygdalar serotonergic function that regulates fear-based behaviors and contributes to the maintenance of PTSD." They say MDMA "may facilitate the processing and release of particularly intractable, potentially developmental, fear-related memories," perhaps "by reopening an oxytocin-dependent critical period of neuroplasticity that typically closes after adolescence."

The researchers hypothesize that "the pharmacological properties of MDMA, when combined with therapy, may produce a 'window of tolerance,' in which participants are able to revisit and process traumatic content without becoming overwhelmed or encumbered by hyperarousal and dissociative symptoms." The aim is to "facilitate recall of negative or threatening memories with greater self-compassion and less PTSD-related shame and anger." That process seems to be enhanced by "the acute prosocial and interpersonal effects of MDMA," which "may support the quality of the therapeutic alliance, a potentially important factor relating to PTSD treatment adherence and outcome."

Last year Reason's Nick Gillespie interviewed MAPS founder Rick Doblin, a co-author of the new study. "Although MAPS is doing everything by the book in seeking approval of MDMA as a prescription drug, Doblin's vision goes beyond such doctor-approved uses," Gillespie noted. "He aspires to a world in which people can use psychedelics responsibly without permission from physicians or priests."

Doblin does not accept the idea that psychoactive substances are inherently good or bad. "Psychedelics are tools," he said. "They're not good or bad in and of themselves. It's how they are used. It's the relationship you have with them." He argued that "people should have the fundamental human right to change their consciousness."

11 May 05:03

How to build *actually* inclusive companies

by Tyler Cowen

How to do build *actually* inclusive companies.

– Dump credentialism.

– Seek talents online wherever they are.

– Build remote, async, international.

That is from Tim Soret, via Balaji.

The post How to build *actually* inclusive companies appeared first on Marginal REVOLUTION.

11 May 03:43

Four “dark horse” stories for 2021

by Tyler Cowen

From my Bloomberg column, here is one of them:

possible Chinese move against Taiwan has received a lot of attention, but a Russian union with Belarus could be a greater danger. Belarus might even agree to such a proposition, so it would be hard for NATO or the U.S. to decry it as a coercive invasion. Yet such a Russian expansion could upend political stability in Europe.

If Russia and Belarus became a single political unit, there would be only a thin band of land, called the Suwalki Gap, connecting the Baltics to the rest of the European Union. Unfortunately, that same piece of territory would stand in the way of the new, larger Russia connecting with the now-cut off Russian region of Kaliningrad. Over the long term, could the Baltics maintain their independence? If not, the European Union would show it is entirely a toothless entity, unable to guarantee the sovereignty of its members.

Even if there were no formal political union between Russia and Belarus, the territorial continuity and integrity of the EU could soon be up for grabs. The EU has more at stake in an independent Belarus than it likes to admit.

You will find three more undervalued possible news stories at the link.

The post Four “dark horse” stories for 2021 appeared first on Marginal REVOLUTION.

06 May 04:35

India: A Wounded Civilization

by ssumner
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India has made a lot of progress in the years since V.S Naipaul wrote India: A Wounded Civilization in 1977. But three recent articles in The Economist demonstrate that, at least in a political sense, India is moving in the same direction as China.

Recall how Xi Jinping responded to Hong Kong election outcomes that he did not like by abolishing the (very limited) democracy in that city-state. Now India’s central government has done the same with New Delhi:

When Narendra Modi, India’s prime minister, stripped Kashmir of its statehood in 2019, most Indians cheered. . . .

Pratap Bhanu Mehta, an academic and columnist for the Indian Express, a national newspaper, was one of the few to raise misgivings. A government that gleefully twisted the law and suspended local democracy in one place could surely do the same in another. Mr Modi proposed to “Indianise” Kashmir, noted Mr Mehta. “Instead, what we will see is potentially the Kashmirisation of India.”

Sooner and closer to home than anyone expected, Mr Mehta’s prediction has come to pass. On March 22nd Mr Modi’s Bharatiya Janata Party (BJP) rushed a bill through the lower house of parliament to strip the elected government of Delhi, the capital, of much of its power and hand this instead to the lieutenant-governor, an official who represents the central government. 

Freedom of speech is also taking a beating:

Despite running what is often hailed as the world’s biggest democracy, [India] has gained a taste for curtailing freedom before speech.

Just ask Siddique Kappan, a journalist who has been detained since October under the Unlawful Activities Prevention Act. His sin was to have been caught driving towards Hathras, a district in the state of Uttar Pradesh. Other reporters had gathered there to cover the alleged gang rape and murder of a Dalit woman by upper-caste men. Mr Kappan never reached the village of the 19-year-old victim, whose family assert that state police sided with her alleged killers, to the point of seizing and cremating her brutalised corpse to conceal the evidence. On the defensive, police have claimed a wider conspiracy to cause caste conflict. They accuse Mr Kappan, arrested at a highway toll booth, of “intent” to stir up trouble of this sort.

Human rights in India’s villages (where most of its people live) are appallingly bad. But things are also getting worse in the universities:

In another move to pre-empt open discussion of touchy issues, the foreign ministry has imposed new rules on academic conferences. In addition to the existing, stringent scrutiny of foreigners invited to conventional events, it will now require state-run institutes and universities to seek prior permission from the ministry for any online conference or seminar “clearly related to India’s internal matters”. Professors may soon find it harder to travel abroad, too. Police in the state of Uttarakhand have announced that henceforth, anyone they deem to have posted “anti-national” content on the internet will not get a passport. Not to be outdone, police in Bihar say that anyone who joins a protest can forget ever having a government job or contract—a jarring rule in a country that won independence through peaceful protest.

The article also details how the internet is being selectively shutdown to prevent protesters from organizing, again a technique pioneered in Kashmir. Kashmir is to India what Xinjiang is to China. The parallels are increasingly frightening.

A third article points out that India’s police are active participants in Modi’s anti-Muslim policies. It also explained that Modi’s virulent Hindu nationalism has deep roots:

It is a shame that India, as a republic, increasingly seems to set aside its own original and excellent toolkit, namely its constitution of 1950. The divergence has been a long and slow process, but there is little doubt it is speeding up. One hint as to why may have been revealed by the culture ministry, which on February 19th, for the first time ever, issued an official tribute to “The Profound Thinker” M.S. Golwalkar, an early leader of the Rashtriya Swayamsevak Sangh or rss, the mothership of the Hindu nationalist movement and progenitor of the BJP. Among other controversial views, Mr Golwalkar believed that Nazi Germany’s management of its Jewish problem “represented a good lesson for us in Hindustan to learn and profit by”. He was not happy with India’s constitution either, judging its makers “not firmly rooted in the conviction of our single homogeneous nationhood”. His call for a change of toolkit has found a powerful audience.

As soon as next year India may surpass China in population. After a few more decades, the gap will grow to hundreds of millions of people. Let’s hope the world’s largest democracy doesn’t become the world’s largest dictatorship.

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