MRV

The importance of fluorinated organic molecules in drugs and pharmaceuticals led to the development of several synthetic methods for introducing fluorine into bioactive molecules and trifluoromethylation is one of the key approaches for the same. Electrochemical organic synthesis has emerged as one of the most sustainable, green synthetic strategies in recent years and new developments in electroorganic synthesis also focus on electrochemical trifluoromethylation of organic compounds. A considerable number of reports have appeared in recent literature and this review surveys all the recent developments in electrochemical trifluoromethylation reactions. This highly sustainable protocol for trifluoromethylation will emerge further soon and pave the way for more energy‐efficient and green protocols.

Photo- and electrochemical transformations represent excellent opportunities for the development of methodologies environmentally friendly and combination of both techniques would result in improved methodologies. Recently, photochemical transformations involving the excitation of open-shell species has become a reality. Photostimulated electron transfer (PET) from radical anions of organic dyes have been used in consecutive photoredox catalysis and electro-photocatalysis transformation, allowing the transformation of aryl halides in valuable compounds under mild conditions. The similarities of both techniques raises the question of the convenience of using one or other related and a close evaluation is necessary to drive further development and have been shyly done in previous works. However, an objective comparison of both approaches will require using the same chemical system. We present here a direct comparison of a “pure” photochemical and an electrophotochemical transformartion studying a model transformation, namely, a C-H substitution in (hetero)aromatic systems with a C-C bond formation through reaction of halogenated substrates. Through a detailed investigation of both mechanisms, we identify a system that could be applied in both approaches with minor (necessaries) changes in the reaction conditions and clearly identify the excitation of radical anion of naphthalene diimides as the key intermediates. Both approaches are comparable in yields and kinetics with slightly better yields for the consecutive PET reaction and better selectivity for the electro-PET process. Our work offers a system that could be used for a more profound comparison of the experimental setups which could include, for instance, the important factor of energy consumption.

We herein disclose the use of an iron catalyst system for an intramolecular C–H amidation toward γ‐lactam synthesis from dioxazolone precursors. (Phthalocyanine)Fe(III)Cl was found to catalyze this cyclization with extremely high turnover numbers up to 47,000 under mild and aerobic conditions. On the basis of experimental and computational mechanistic studies, the reaction was suggested to proceed via a stepwise radical pathway involving fast hydrogen atom abstraction followed by radical rebound. Plausible origin of extremely high turnover numbers along with air‐compatibility was also rationalized.

Synlett
DOI: 10.1055/s-0040-1705955

In this Account, the development of Select Crowd Reviewing from the initial idea through a pilot phase to the present moment, when it is now used as the default method for the evaluation of manuscripts at Synlett and SynOpen is detailed. We describe the workflow through which a manuscript is evaluated when Select Crowd Reviewing is applied. A series of questions and answers is used to address typical concerns and the advantages Select Crowd Reviewing offers when compared to traditional peer review.1 Introduction: The History of Select Crowd Reviewing2 The Select Crowd Reviewing Workflow3 Questions We Have Received Regarding Select Crowd Reviewing4 Conclusion
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