Pierrot

Shared posts

27 Mar 10:12

Total synthesis of alkaloids using both chemical and biochemical methods

Nat. Prod. Rep., 2020, 37,1098-1121
DOI: 10.1039/C9NP00073A, Review Article
Ryo Tanifuji, Atsushi Minami, Hiroki Oguri, Hideaki Oikawa
A chemoenzymatic approach to synthesize structurally complex natural alkaloids (tetrahydroisoquinoline antibiotics, indole diterpenes, and monoterpene indole alkaloids) has been reviewed.
The content of this RSS Feed (c) The Royal Society of Chemistry
02 Dec 16:07

An Iron/Amine-Catalyzed Cascade Process for the Enantioselective Functionalization of Allylic Alcohols

by Adrien Quintard, Thierry Constantieux, Jean Rodriguez
Thumbnail image of graphical abstract

Three is a lucky number: An enantioselective transformation of allylic alcohols into β-chiral saturated alcohols has been developed by combining two distinct metal- and organocatalyzed catalytic cycles. This waste-free triple cascade process merges an iron-catalyzed borrowing-hydrogen step with an aminocatalyzed nucleophilic addition reaction.