Nature, Published online: 09 December 2019; doi:10.1038/d41586-019-03730-x
A double membrane protects certain bacteria from antibiotics, but compounds have now been generated that can overcome this obstacle, seemingly by targeting a crucial protein in the outer membrane.Qinheng Zheng
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30 Apr 21:25
[ASAP] Cu(I)-Catalyzed Aminative Aza-Annulation of Enynyl Azide using N-Fluorobenzenesulfonimide: Synthesis of 5-Aminonicotinates
by Chada Raji Reddy, Santosh Kumar Prajapti, Ravi Ranjan
Organic Letters
DOI: 10.1021/acs.orglett.8b01228
wangruijia likes this
13 Jun 18:55
Dibenzothiophene Sulfoximine as an NH3 Surrogate in the Synthesis of Primary Amines by Copper-Catalyzed C−X and C−H Bond Amination
by Li Zhen, Hao Yu, Carsten Bolm
Abstract
Readily accessible dibenzothiophene sulfoximine is an NH3 surrogate allowing the preparation of free anilines by copper-catalyzed cross-coupling reactions with aryl iodides or amides followed by radical S−N bond cleavage. The one-pot/two-step reactions sequence leads to the aminated products in good yields.
A useful substitute: Dibenzothiophene sulfoximine is an NH3 surrogate allowing halo arenes and amides to be converted into aminated analogues by copper-catalyzed Buchwald–Hartwig-type or dehydrogenative C−H/N−H cross-coupling reactions followed by radical sulfoxide cleavage.
longzhi zhu, Mickael.henrion and 2 others like this
18 Aug 15:52
Structure and Reactivity of Indolylmethylium Ions: Scope and Limitations in Synthetic Applications
by Elsa Follet, Guillaume Berionni, Peter Mayer and Herbert Mayr
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.5b01298
zhangjishu and -1 others like this
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