Accounts of Chemical Research
DOI: 10.1021/acs.accounts.8b00408
The brain is required for normal muscle and nerve patterning during early Xenopus development
Nature Communications, Published online: 25 September 2017; doi:10.1038/s41467-017-00597-2
Functions of the embryonic brain prior to regulating behavior are unclear. Here, the authors use an amputation assay in Xenopus laevis to demonstrate that removal of the brain early in development alters muscle and peripheral nerve patterning, which can be rescued by modulating bioelectric signals.