Miao Qi

Publication date: 1 January 2025

Source: Bioorganic & Medicinal Chemistry, Volume 117

Author(s): Liying Zhang, Zhiheng Deng, Yunxiang Du, Ziyu Xu, Tianyi Zhang, Zebin Tong, Huasong Ai, Lu-Jun Liang, Lei Liu

Nature Structural & Molecular Biology, Published online: 08 October 2024; doi:10.1038/s41594-024-01399-z

The authors present structures of endosomal sorting complexes required for transport III family member vesicle-inducing protein in plastids 1, ranging from helical assemblies and stacked rings to flat carpets, providing insights into transitions dependent on membrane tubulation and curvature needed for forming different architectures involved in membrane remodeling.

Duan et al. developed a panel of isogenic murine pancreatic organoids containing common PDAC driver mutations to screen for KRAS mutation inhibitors and identified that perhexiline maleate can target KRAS mutation by downregulating the cholesterol biosynthesis pathway, which is specifically induced by KRAS mutation.

An N-substituted asymmetric nonfullerene acceptor SN with an over 40 nm bathochromically shifted absorption compared to Y6 is designed and synthesized. The PM6 : SN-based binary cell exhibits the lowest nonradiative voltage loss of 0.15 eV ever achieved by organic solar cells (OSCs). Benefiting from extended NIR absorption and lowered voltage loss, PM6 : Y6 : SN-based semitransparent (ST)-OSCs, for the first time, achieve a power conversion efficiency of 14 % with an average visible transmittance over 20 %.

Abstract

Semitransparent organic solar cells (ST-OSCs) are considered as one of the most valuable applications of OSCs and a strong contender in the market. However, the optical band gap of current high-performance ST-OSCs is still not low enough to achieve the optimal balance between power conversion efficiency (PCE) and average visible transmittance (AVT). An N-substituted asymmetric nonfullerene acceptor SN with over 40 nm bathochromically shifted absorption compared to Y6 was designed and synthesized, based on which the device with PM6 as donor obtained a PCE of 14.3 %, accompanied with a nonradiative voltage loss as low as 0.15 eV. Meanwhile, ternary devices with the addition of SN into PM6 : Y6 can achieve a PCE of 17.5 % with an unchanged open-circuit voltage and improved short-circuit current. Benefiting from extended NIR absorption and lowered voltage loss, ST-OSCs based on PM6 : SN : Y6 were fabricated and the optimized device demonstrated a PCE of 14.0 % at an AVT of 20.2 %, which is the highest PCE at an AVT over 20 %.

Three's a crowd: A highly enantioselective Rh^II‐catalyzed cyclopropenation reaction of difluorodiazoethane (PhSO₂CF₂CHN₂) with challenging internal alkynes is reported (up to 99 % yield, 97 % ee). Versatile stereoselective transformations of these unique strained cyclopropenes are also demonstrated.

Abstract

Herein we described an efficient Rh^II‐catalyzed enantioselective cyclopropenation reaction of internal alkynes with a masked difluorodiazoethane reagent (PhSO₂CF₂CHN₂, Ps‐DFA). This asymmetric transformation offers efficient access to a broad range of enantioenriched difluoromethylated cyclopropenes (40 examples, up to 99 % yield, 97 % ee). The synthetic utility of obtained strained carbocycles is demonstrated by subsequent stereodefined processes, including cross‐couplings, hydrogenation, Diels–Alder reaction, and Pauson–Khand reaction.

Publication date: 15 October 2019

Source: Bioorganic & Medicinal Chemistry Letters, Volume 29, Issue 20

Author(s): Jerald J. Nair, Johannes van Staden

Publication date: 15 June 2019

Source: Bioorganic & Medicinal Chemistry Letters, Volume 29, Issue 12

Author(s): Kuojun Zhang, Yong Ni, Jiaxuan Chen, Zhengchao Tu, Xiaoxing Wu, Dong Chen, Hequan Yao, Sheng Jiang

Publication date: 15 February 2017
Source:Bioorganic & Medicinal Chemistry Letters, Volume 27, Issue 4
Author(s): Francisco G. Avalos-Alanís, Eugenio Hernández-Fernández, Pilar Carranza-Rosales, Susana López-Cortina, Jorge Hernández-Fernández, Mario Ordóñez, Nancy E. Guzmán-Delgado, Alejandro Morales-Vargas, Víctor M. Velázquez-Moreno, María G. Santiago-Mauricio
The synthesis of six α,β,-unsaturated amides and six 2,4-disubstituted oxazolines derivatives and their evaluation against two Mycobacterium tuberculosis strains (sensitive H37Rv and a resistant clinical isolate) is reported. 2,4-Disubstituted oxazolines (S)-3b,d,e were the most active in the sensitive strain with a MIC of 14.2, 13.6 and 10.8μM, respectively, and the compounds (S)-3d,f were the most active against resistant strain with a MIC of 6.8 and 7.4μM. The ex-vivo evaluation of hepatotoxicity on precision-cut rat liver slices was also tested for the α,β-unsaturated amides (S)-2b and (S)-2d,f and for the oxazolines (S)-3b and (S)-3d,f at different concentrations (5, 15 and 30μg/mL). The results indicate that these compounds possess promising antimycobacterial activity and at the same time are not hepatotoxic. These findings open the possibility for development of new drugs against tuberculosis.

Graphical abstract

A novel family of well-defined molecular lithium boracarbonate ion pairs containing a unique boron-implanted cyclic carbonate framework are efficiently synthesized by the highly selective coupling reaction of CO₂, bis(pinacolato)diboron, LiOtBu, and a wide range of aldehydes in the presence of an N-heterocyclic carbene copper catalyst.

[Communication]
Béatrice Carry, Liang Zhang, Masayoshi Nishiura, Zhaomin Hou
Angew. Chem. Int. Ed., April 09, 2016, DOI: 10.1002/anie.201602278. Read article