18 Aug 14:24
by ChangYou
,
ChaoPi
,
YangjieWu
,
XiulingCui
Abstract
A highly efficient Rh‐catalyzed regioselective C8−H acylmethylation of quinoline N‐oxides with sulfoxonium ylides using N‐oxide as the directing group under air atmosphere has been developed. This transformation has the generality of a broad scope of substrates, avoids external oxidants, and provides an efficient protocol to C8−H acylmethylated quinolines.
23 Jan 12:24
by Rui Zhang, Haifei Yu, Zejiang Li, Qinqin Yan, Pan Li, Jilai Wu, Jing Qi, Menglu Jiang, Lixian Sun
Abstract
A radical azidomethylation of various alkenes with azidotrimethylsilane and dimethyl sulfoxide has been achieved under mild reaction conditions, and the method efficiently introduces common and valuable azide and methyl groups into organic compounds. It offers a convenient method for preparing organic azides, which can be easily transformed into related amine derivatives and N-heterocycles. Control experiments such as capturing of the intermediate and gram-scale reactions of the developed system as well as further transformations of the products of the reaction are presented. And a free radical is involved in the reaction process.
06 Dec 14:42
by Junliang Zhang, Peng Chen, Junyou Zhang
Abstract
A highly efficient phosphine-catalyzed [4+2] annulation of electron-deficient diene and alkyl vinyl ketone was developed for the first time, which provides an easy access to functionalized cyclohexenes. This method has the advantages of mild reaction conditions, widely functional group tolerance, high yields and transition metal free.
04 Oct 07:49
by Yunhe Jin, Lunyu Ou, Haijun Yang and Hua Fu
Journal of the American Chemical Society
DOI: 10.1021/jacs.7b07883
16 Sep 13:20
by Gang Li, Biao Zhu, Xingxing Ma, Chunqi Jia, Xulu Lv, Junjie Wang, Feng Zhao, Yunhe Lv and Suling Yang
Organic Letters
DOI: 10.1021/acs.orglett.7b02439
28 Jul 12:45
by Li-Jie Cheng and Neal P. Mankad
Journal of the American Chemical Society
DOI: 10.1021/jacs.7b05205
07 May 02:44
by Alexey V. Galenko, Firuza M. Shakirova, Ekaterina E. Galenko, Mikhail S. Novikov and Alexander F. Khlebnikov
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.7b00736
24 Jan 02:34
by Zhen Wu, Dongping Wang, Yuan Liu, Leitao Huan and Chen Zhu
Journal of the American Chemical Society
DOI: 10.1021/jacs.6b11234