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17 Apr 06:33

Antibiotics, Vol. 12, Pages 768: Provision of Microbiology, Infection Services and Antimicrobial Stewardship in Intensive Care: A Survey across the Critical Care Networks in England and Wales

by Tim Catton

Antibiotics, Vol. 12, Pages 768: Provision of Microbiology, Infection Services and Antimicrobial Stewardship in Intensive Care: A Survey across the Critical Care Networks in England and Wales

Antibiotics doi: 10.3390/antibiotics12040768

Authors: Tim Catton Helen Umpleby Ahilanandan Dushianthan Kordo Saeed

Infection rounds in Intensive Care Units (ICU) can impact antimicrobial stewardship (AMS). The aim of this survey was to assess the availability of microbiology, infection, AMS services, and antimicrobial prescribing practices in the UK ICUs. An online questionnaire was sent to clinical leads for ICUs in each region listed in the Critical Care Network for the UK. Out of 217 ICUs, 87 deduplicated responses from England and Wales were analyzed. Three-quarters of those who responded had a dedicated microbiologist, and 50% had a dedicated infection control prevention nurse. Infection rounds varied in their frequency, with 10% providing phone advice only. Antibiotic guidance was available in 99% of the units; only 8% of those were ICU-specific. There were variations in the availability of biomarkers & the duration of antibiotics prescribed for pneumonia (community, hospital, or ventilator), urinary, intra-abdominal, and line infections/sepsis. Antibiotic consumption data were not routinely discussed in a multi-disciplinary meeting. The electronic prescription was available in ~60% and local antibiotic surveillance data in only 47% of ICUs. The survey highlights variations in practice and AMS services and may offer the opportunity to further collaborations and share learnings to support the safe use of antimicrobials in the ICU.

12 Feb 13:05

Catalytic asymmetric synthesis of 5-membered alicyclic α-quaternary β-amino acids via [3 + 2]-photocycloaddition of α-substituted acrylates

Org. Biomol. Chem., 2021, 19,1744-1747
DOI: 10.1039/D1OB00126D, Communication
Yuto Kimura, Daisuke Uraguchi, Takashi Ooi
A highly stereoselective, photocatalytic [3 + 2]-cycloaddition was developed for providing a variety of stereochemically defined 5-membered alicyclic α-quaternary β-amino acids.
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