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13 Mar 07:28

New approaches and techniques for bacterial cell wall analysis

by Sara B Hernández

Curr Opin Microbiol. 2021 Feb 22;60:88-95. doi: 10.1016/j.mib.2021.01.010. Online ahead of print.

ABSTRACT

Peptidoglycan (PG) has remained for decades in the spotlight of the never-ending battle against pathogenic bacteria as this essential bacterial structure is one of the most successful targets for antibiotics. Most of our current understanding about the composition, architecture, and dynamics of the PG relies on techniques which have experienced great technological and methodological improvements in the past years. Here we summarize recent advances in these methods with the intention to furnish a valuable resource for both PG experts and newcomers.

PMID:33631455 | DOI:10.1016/j.mib.2021.01.010

20 May 13:38

[ASAP] Endogenous Enzymes Enable Antimicrobial Activity

by Kenton J. Hetrick, Miguel A. Aguilar Ramos, and Ronald T. Raines

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ACS Chemical Biology
DOI: 10.1021/acschembio.0c00894
20 May 13:37

[ASAP] Genomic-Led Discovery of a Novel Glycopeptide Antibiotic by Nonomuraea coxensis DSM 45129

by Oleksandr Yushchuk, Natalia M. Vior, Andres Andreo-Vidal, Francesca Berini, Christian Rückert, Tobias Busche, Elisa Binda, Jörn Kalinowski, Andrew W. Truman, and Flavia Marinelli

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ACS Chemical Biology
DOI: 10.1021/acschembio.1c00170
20 May 13:36

[ASAP] Non-Native Peptides Capable of Pan-Activating the agr Quorum Sensing System across Multiple Specificity Groups of Staphylococcus epidermidis

by Korbin H. J. West, Wenqi Shen, Emma L. Eisenbraun, Tian Yang, Joseph K. Vasquez, Alexander R. Horswill, and Helen E. Blackwell

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ACS Chemical Biology
DOI: 10.1021/acschembio.1c00240
20 May 13:36

[ASAP] Glycosylation Regulates N-Terminal Proteolysis and Activity of the Chemokine CCL14

by Siyao Wang, Simon R. Foster■, Julie Sanchez, Leo Corcilius, Mark Larance, Meritxell Canals, Martin J. Stone, and Richard J. Payne

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ACS Chemical Biology
DOI: 10.1021/acschembio.1c00006
20 May 13:35

[ASAP] Mycobacterium tuberculosis PanD Structure–Function Analysis and Identification of a Potent Pyrazinoic Acid-Derived Enzyme Inhibitor

by Priya Ragunathan, Malcolm Cole, Chitra Latka, Wassihun Wedajo Aragaw, Pooja Hegde, Joon Shin, Malathy Sony Subramanian Manimekalai, Sankaranarayanan Rishikesan, Courtney C. Aldrich, Thomas Dick, and Gerhard Grüber

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ACS Chemical Biology
DOI: 10.1021/acschembio.1c00131
20 May 13:35

[ASAP] Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane

by Kristina Klobucar, Jean-Philippe Côté, Shawn French, Louis Borrillo, Amelia Bing Ya Guo, Michael H. Serrano-Wu, Katie K. Lee, Brian Hubbard, Jarrod W. Johnson, Jeffrey L. Gaulin, Jakob Magolan, Deborah T. Hung, and Eric D. Brown

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ACS Chemical Biology
DOI: 10.1021/acschembio.1c00179