Patrick Zanon

Scientific Reports, Published online: 23 April 2026; doi:10.1038/s41598-026-48534-y

Fixed-point topology meets fractal memory: a Kutumba-stabilized framework for nonlocal fractal–fractional dynamics

Traffic-related diesel exhaust particles (DEP) disrupt the airway epithelial barrier and drive allergic asthma via thymic stromal lymphopoietin (TSLP) release. A series of adamantane-1-carboxamide N-acylthiourea derivatives are designed and synthesized. Lead compound AD4 dose-dependently upregulates PP4, restores epithelial integrity, and strongly suppresses DEP-induced TSLP in BEAS-2B cells, emerging as a promising novel therapeutic candidate for allergic airway inflammation.

Airway epithelial cells (AECs) serve as the first line of defense against environmental pollutants, with exposure to traffic-related particles known to exacerbate allergic asthma. In this study, a series of adamantane-containing N-acylthiourea compounds are designed, synthesized, and structurally characterized by ¹H NMR, ¹³C NMR, HR-ESI-MS, FT-IR, and UV–vis spectroscopy. Among them, compound AD3, is crystallized in the triclinic P-1 space group. Here, it is found that AD4 upregulated the expression of protein phosphatase 4 (PP4) in BEAS-2B airway epithelial cells in a concentration-dependent manner. AD4 treatment also significantly restored epithelial barrier integrity and suppressed the production of thymic stromal lymphopoietin (TSLP) production challenged by diesel exhaust particles (DEP). To the author's knowledge, this represents the first report identifying AD4 as a potential therapeutic agent for allergic asthma, highlighting a novel strategy for antiallergic drugs.

Publication date: 16 October 2025

Source: Cell Chemical Biology, Volume 32, Issue 10

Author(s): Mohamed A. Anany, Daniela Siegmund, Olena Zaitseva, Isabell Lang, Bayan Mouhandes, Mervat Salah, Daniela Weisenberger, Svetlana Stepanzow, Juan Gamboa Vargas, Julia Dahlhoff, Theresa Schneider, Giel Tanghe, Frederik Stevenaert, Tugsan Tezil, Tom Van Belle, Bipasa Kar, Thomas Dandekar, Heike Margarete Hermanns, Luc van Rompaey, Andreas Beilhack