Shoukun Zhang

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05 Jun 22:54

Electrocatalytic ORR–coupled ammoximation for efficient oxime synthesis

by Yujia Yuan, Lisong Chen, Zhipeng Wan, Kai Shi, Xue Teng, Hao Xu, Peng Wu, Jianlin Shi
Science Advances, Volume 10, Issue 21, May 2024.
13 Jan 02:49

Ancient DNA elucidates the lost world of western Indian Ocean giant tortoises and reveals a new extinct species from Madagascar

by Christian Kehlmaier, Eva Graciá, Jason R. Ali, Patrick D. Campbell, Sandra D. Chapman, V. Deepak, Flora Ihlow, Nour-Eddine Jalil, Laure Pierre-Huyet, Karen E. Samonds, Miguel Vences, Uwe Fritz
Science Advances, Volume 9, Issue 2, January 2023.
29 Mar 13:49

A Highly Sensitive CRISPR‐Empowered Surface Plasmon Resonance Sensor for Diagnosis of Inherited Diseases with Femtomolar‐Level Real‐Time Quantification

by Fei Zheng, Zhi Chen, Jingfeng Li, Rui Wu, Bin Zhang, Guohui Nie, Zhongjian Xie, Han Zhang
A Highly Sensitive CRISPR-Empowered Surface Plasmon Resonance Sensor for Diagnosis of Inherited Diseases with Femtomolar-Level Real-Time Quantification

This paper presents a surface plasmon resonance (SPR) based, femtomolar-level, pre-amplification-free, real-time genomic DNAs quantification platform "CRISPR-eSPR". This unprecedented specificity and efficiency are achieved by the innovative marriage of the unique sequence-specific recognizing ability of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas system and the superior sensitivity of the 2D-material enforced Surface Plasmon Resonance sensor. The feasibility of clinical diagnosis has been strongly proved.


Abstract

The clustered regularly interspaced short palindromic repeats (CRISPR) molecular system has emerged as a promising technology for the detection of nucleic acids. Herein, the development of a surface plasmon resonance (SPR) sensor that is functionalized with a layer of locally grown graphdiyne film, achieving excellent sensing performance when coupled with catalytically deactivated CRISPR-associated protein 9 (dCas9), is reported. dCas9 protein is immobilized on the sensor surface and complexed with a specific single-guide RNA, enabling the amplification-free detection of target sequences within genomic DNA. The sensor, termed CRISPR-SPR-Chip, is used to successfully analyze recombinant plasmids with only three-base mutations with a limit of detection as low as 1.3 fM. Real-time monitoring CRISPR-SPR-Chip is used to analyze clinical samples of patients with Duchenne muscular dystrophy with two exon deletions, which are detected without any pre-amplification step, yielding significantly positive results within 5 min. The ability of this novel CRISPR-empowered SPR (CRISPR-eSPR) sensing platform to rapidly, precisely, sensitively, and specifically detect a target gene sequence provides a new on-chip optic approach for clinical gene analysis.

03 Nov 17:30

[ASAP] Enhanced CO2 Electrochemical Reduction Performance over Cu@AuCu Catalysts at High Noble Metal Utilization Efficiency

by Sheng Dai, Tzu-Hsi Huang, Wei-I Liu, Chia-Wei Hsu, Sheng-Wei Lee, Tsan-Yao Chen, Ya-Chen Wang, Jeng-Han Wang, and Kuan-Wen Wang

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Nano Letters
DOI: 10.1021/acs.nanolett.1c03483
30 Sep 13:03

[ASAP] Ni(II)-Catalyzed Intramolecular C–H/C–H Oxidative Coupling: An Efficient Route to Functionalized Cycloindolones and Indenoindolones

by Shidheshwar B. Ankade, Pragnya Paramita Samal, Vineeta Soni, Rajesh G. Gonnade, Sailaja Krishnamurty, and Benudhar Punji

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ACS Catalysis
DOI: 10.1021/acscatal.1c03314
31 Jul 05:41

Make it stereoscopic: interfacial design for full-temperature adaptive flexible zinc–air batteries

Energy Environ. Sci., 2021, 14,4926-4935
DOI: 10.1039/D1EE01244D, Paper
Zengxia Pei, Luyao Ding, Cheng Wang, Qiangqiang Meng, Ziwen Yuan, Zheng Zhou, Shenlong Zhao, Yuan Chen
A flexible zinc–air battery fabricated from a stereoscopic air-cathode and a rationalized polyelectrolyte affords excellent electrochemical performances with flexibility in a broad temperature range of −30 to 80 °C.
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24 May 19:32

[ASAP] Metal-, Photocatalyst-, and Light-Free Minisci C–H Acetylation of N-Heteroarenes with Vinyl Ethers

by Jianyang Dong, Jianhua Liu, Hongjian Song, Yuxiu Liu, and Qingmin Wang

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Organic Letters
DOI: 10.1021/acs.orglett.1c01310
11 May 23:11

Defect‐Rich Porous Palladium Metallene for Enhanced Alkaline Oxygen Reduction Electrocatalysis

by Hongjie Yu, Tongqing Zhou, Ziqiang Wang, You Xu, Xiaonian Li, Liang Wang, Hongjing Wang
Defect‐Rich Porous Palladium Metallene for Enhanced Alkaline Oxygen Reduction Electrocatalysis

Ultrathin porous Pd metallene with rich nanocrystal defects were prepared by a one‐pot wet‐chemical method for superior oxygen reduction reaction performance in alkaline electrolytes.


Abstract

Metallene with fantastic physicochemical properties is considered as a potential candidate for oxygen reduction reaction (ORR). Controlling the morphology and structure of metallene can provide a great opportunity to improve its catalytic performance. Herein, defect‐rich ultrathin porous Pd metallene (a sub‐nanometer and curved metal nanosheet) is developed by facile wet‐chemistry strategy for efficient and stable ORR electrocatalysis in alkaline electrolyte. The defect‐rich porous Pd metallene provides abundant highly active sites and vacancy defects, showing superior ORR activity of 0.892 A mgPd −1 at 0.9 V vs. the reversible hydrogen electrode. The mass activity is 5.1 and 16.8 times higher than those of commercial Pt/C and Pd/C, respectively, and maintains well after 5000 cycles. The strain effect and tunable electronic structure derived from highly curved sub‐nanometer nanosheet morphology contribute to the excellent ORR performance by the optimization of oxygen binding ability on Pd. The superior catalytic performance of Pd metallene may open an avenue to design other metallene materials for various fields.