The triazole makes the difference. Replacement of amide bonds in the backbone of peptides by 1,4-disubstituted 1,2,3-triazole isosteres affords peptidomimetics with retained receptor affinity and cell-internalization properties, enhanced proteolytic stability, and improved tumor-targeting capabilities.
Angus Logan
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08 Jul 08:31
1,2,3-Triazoles as Amide Bond Mimics: Triazole Scan Yields Protease-Resistant Peptidomimetics for Tumor Targeting
by Ibai E. Valverde, Andreas Bauman, Christiane A. Kluba, Sandra Vomstein, Martin A. Walter, Thomas L. Mindt
Leuchtkaefer, Marcos Pires and -1 others like this
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