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09 Jun 03:51

TPP-based mitocans: a potent strategy for anticancer drug design

RSC Med. Chem., 2020, 11,858-875
DOI: 10.1039/C9MD00572B, Review Article
Jiayao Wang, Jiaqi Li, Yumei Xiao, Bin Fu, Zhaohai Qin
Triphenylphosphonium can selectively target various “cargos” to mitochondria based on the high mitochondrial membrane potential of tumor cells.
The content of this RSS Feed (c) The Royal Society of Chemistry
12 Apr 19:39

Deciphering the EU clinical trials regulation

by Mohamed Abou-El-Enein

Nature Biotechnology 34, 231 (2016). doi:10.1038/nbt.3492

Authors: Mohamed Abou-El-Enein & Christian K Schneider

25 Oct 02:17

FDA approves new therapy for certain types of advanced soft tissue sarcoma

The U.S. Food and Drug Administration today approved Yondelis (trabectedin), a chemotherapy, for the treatment of specific soft tissue sarcomas (STS) – liposarcoma and leiomyosarcoma – that cannot be removed by surgery (unresectable) or is advanced (metastatic). This treatment is approved for patients who previously received chemotherapy that contained anthracycline.