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23 Apr 05:55

[ASAP] Conflicting Role of Inversion of the LiMn2O4 Spinel on Lithium-Ion Battery Capacity from First-Principles Calculations

by Zijing Wan, Yaxin Xu, Guoqing Sun, Dongwei Xu, and Xiaobing Luo

TOC Graphic

The Journal of Physical Chemistry C
DOI: 10.1021/acs.jpcc.2c00274
16 Dec 03:19

Cancer Therapy: Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy (Adv. Mater. 50/2020)

by Dan Shao, Fan Zhang, Fangman Chen, Xiao Zheng, Hanze Hu, Chao Yang, Zhaoxu Tu, Zheng Wang, Zhimin Chang, Junna Lu, Tianyu Li, Yuan Zhang, Li Chen, Kam W. Leong, Wen‐fei Dong
Cancer Therapy: Biomimetic Diselenide‐Bridged Mesoporous Organosilica Nanoparticles as an X‐ray‐Responsive Biodegradable Carrier for Chemo‐Immunotherapy (Adv. Mater. 50/2020)

In article number 2004385, Dan Shao, Kam W. Leong, Wen‐fei Dong, and co‐workers present cancer‐cell‐membrane‐coated mesoporous organosilica nanoparticles for radiation‐responsive drug delivery and cancer chemo‐immunotherapy. Under low‐dose X‐ray radiation, such biomimetic nanotherapeutics exhibit degradation‐controlled drug release and induced stronger antitumor immune responses, leading to enhanced tumor regression and metastasis inhibition with low systematic toxicity when combined with anti‐PD‐L1.


23 Dec 01:48

[ASAP] Crystal–Amorphous Core–Shell Structure Synergistically Enabling TiO2 Nanoparticles’ Remarkable SERS Sensitivity for Cancer Cell Imaging

by Jie Lin†§, Wenzhi Ren†§, Anran Li‡§, Chenyang Yao†, Tianxiang Chen†, Xuehua Ma†, Xiaotian Wang*‡, and Aiguo Wu*†

TOC Graphic

ACS Applied Materials & Interfaces
DOI: 10.1021/acsami.9b17150
12 Nov 04:32

Searching for Small Molecules with an Atomic Sort

by Brendan M Duggan, Reiko Cullum, William Fenical, Luis A Amador, Abimael D. Rodríguez, James J. La Clair
Angewandte Chemie International Edition Searching for Small Molecules with an Atomic Sort

The discovery of biologically active small molecules requires sifting through large amounts of data to identify unique or unusual arrangements of atoms. Here, an atom‐based sort is developed, tested and evaluated to identify novel features of secondary metabolites, outlining an important step towards the translation of autonomous systems to identify atomic novelty within a complex mixture of small molecules.


Abstract

The discovery of biologically active small molecules requires sifting through large amounts of data to identify unique or unusual arrangements of atoms. Here, we develop, test and evaluate an atom‐based sort to identify novel features of secondary metabolites and demonstrate its use to evaluate novelty in marine microbial and sponge extracts. This study outlines an important ongoing advance towards the translation of autonomous systems to identify, and ultimately elucidate, atomic novelty within a complex mixture of small molecules.

03 Jan 05:34

Use of silylmethoxy groups as inducers of efficient room temperature phosphorescence from precious-metal-free organic luminophores

Mater. Chem. Front., 2018, 2,347-354
DOI: 10.1039/C7QM00524E, Research Article
Masaki Shimizu, Takumi Kinoshita, Ryosuke Shigitani, Yusuke Miyake, Kunihiko Tajima
Crystals of and PMMA films doped with 2,5-bis(silylmethoxy)-1,4-diaroylbenzenes exhibit efficient green phosphorescence at room temperature.
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17 May 06:03

Flexible and Stretchable 3ω Sensors for Thermal Characterization of Human Skin

by Limei Tian, Yuhang Li, Richard Chad Webb, Siddharth Krishnan, Zuguang Bian, Jizhou Song, Xin Ning, Kaitlyn Crawford, Jonas Kurniawan, Andrew Bonifas, Jun Ma, Yuhao Liu, Xu Xie, Jin Chen, Yuting Liu, Zhan Shi, Tianqi Wu, Rui Ning, Daizhen Li, Sanjiv Sinha, David G. Cahill, Yonggang Huang, John A. Rogers

Characterization of the thermal properties of the surface and subsurface structures of the skin can reveal the degree of hydration, the rate of blood flow in near-surface micro- and macrovasculature, and other important physiological information of relevance to dermatological and overall health status. Here, a soft, stretchable thermal sensor, based on the so-called three omega (i.e., 3ω) method, is introduced for accurate characterization of the thermal conductivity and diffusivity of materials systems, such as the skin, which can be challenging to measure using established techniques. Experiments on skin at different body locations and under different physical states demonstrate the possibilities. Systematic studies establish the underlying principles of operation in these unusual systems, thereby allowing rational design and use, through combined investigations based on analytical modeling, experimental measurements, and finite element analysis. The findings create broad opportunities for 3ω methods in biology, with utility ranging from the integration with surgical tools or implantable devices to noninvasive uses in clinical diagnostics and therapeutics.

Thumbnail image of graphical abstract

A soft, stretchable thermal sensor based on the three omega (i.e., 3ω) method enables accurate characterization of the thermal properties of diverse materials systems such as the human skin. Rational design of these sensors creates broad opportunities for 3ω methods in biology, with utility ranging from integration with surgical tools or implantable devices to noninvasive uses in clinical diagnostics and therapeutics.