Nature Chemistry, Published online: 08 April 2025; doi:10.1038/s41557-025-01796-x
A photoswitchable, DNA structure-specific small-molecule probe, named G4switch, has been developed for the reversible targeting of DNA G-quadruplexes (G4s) in vitro and within cells. This versatile chemical tool enables precise, light-controlled modulation of G4-mediated gene expression and cell proliferation.