28 Feb 16:30
Chem. Commun., 2022, 58,3847-3864
DOI: 10.1039/D2CC00369D, Highlight
Yanan Wang, Yanyang Bao, Meifang Tang, Zhegao Ye, Zheliang Yuan, Gangguo Zhu
This review summarises recent applications of pyridinium salts in radical-mediated difunctionalization of alkenes. We hope this review will provide a comprehensive overview of this topic and promote the wider development and application of pyridinium salts.
The content of this RSS Feed (c) The Royal Society of Chemistry
16 Feb 13:58
by Mina Yamane, Yamato Kanzaki, Harunobu Mitsunuma, and Motomu Kanai
Organic Letters
DOI: 10.1021/acs.orglett.2c00138
27 Jan 08:47
by Kengo Hyodo, Kensho Miki, and Tomoya Yauchi
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.1c02809
27 Jan 08:45
by Wenxuan Zhang, Ran Song, Daoshan Yang, and Jian Lv
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.1c02750
18 Jan 17:03
by Xu Cheng, Aiwen Lei, Tian-Sheng Mei, Hai-Chao Xu, Kun Xu & Chengchu Zeng1School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 2100232College of Chemistry and Molecular Sciences, Institute for Advanced Studies (IAS), Wuhan University, Wuhan 4300723State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 2000324State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 3610055Faculty of Environment and Life, Beijing University of Technology, Beijing 100124
CCS Chemistry, <a href="https://www.chinesechemsoc.org/toc/ccschem/4/4">Volume 4, Issue 4</a>, Page 1120-1152, April 2022.
04 Jan 10:07
Chem. Sci., 2022, 13,1088-1094
DOI: 10.1039/D1SC06613G, Edge Article
Open Access
Hui Liang, Dong-Sheng Ji, Guo-Qiang Xu, Yong-Chun Luo, Haixue Zheng, Peng-Fei Xu
We have developed a metal-free, visible-light driven chiral phosphoric acid catalyzed asymmetric intermolecular, three-component radical-initiated dicarbofunctionalization and oxytrifluoromethylation of enamines.
The content of this RSS Feed (c) The Royal Society of Chemistry
MRV and -1 others like this
02 Jan 22:02
by Alexander L. Guzman and Thomas R. Hoye
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.1c02590
30 Dec 17:07
by Nicholas P. Taylor, Jorge A. Gonzalez, Gary S. Nichol, Andrés García-Domínguez, Andrew G. Leach, and Guy C. Lloyd-Jones
The Journal of Organic Chemistry
DOI: 10.1021/acs.joc.1c02729
30 Dec 16:41
Chem. Commun., 2022, 58,730-746
DOI: 10.1039/D1CC05730H, Highlight
Pin Gao, Yue-Jie Niu, Fan Yang, Li-Na Guo, Xin-Hua Duan
This article provides a comprehensive perspective on three-component 1,2-dicarbofunctionalization of alkenes involving alkyl radicals, which generated from structurally diverse electrophilic and nucleophilic precursors under mild conditions.
The content of this RSS Feed (c) The Royal Society of Chemistry
30 Dec 14:54
by Aurélie Claraz and Géraldine Masson
ACS Organic & Inorganic Au
DOI: 10.1021/acsorginorgau.1c00037
20 Dec 11:05
by Salim Javed, Arghya Ganguly, Gihan C. Dissanayake, and Paul R. Hanson
Organic Letters
DOI: 10.1021/acs.orglett.1c03350
11 Dec 20:42
by Yueyue Ma, Jufei Hong, Xiantong Yao, Chengyu Liu, Ling Zhang, Youtian Fu, Maolin Sun, Ruihua Cheng, Zhong Li, and Jinxing Ye
Organic Letters
DOI: 10.1021/acs.orglett.1c03500
11 Dec 20:06
Org. Biomol. Chem., 2022, 20,362-365
DOI: 10.1039/D1OB02291A, Communication
Aline Makhloutah, Danylo Hatych, Thomas Chartier, Lou Rocard, Antoine Goujon, François-Xavier Felpin, Piétrick Hudhomme
The first Stille-type coupling is described using nitro-perylenediimide as the electrophile and various aryl and heteroaryl organostannes.
The content of this RSS Feed (c) The Royal Society of Chemistry
05 Dec 22:15
by Mrinmay Baidya,
Debabrata Maiti,
Lisa Roy,
Suman De Sarkar
A chemoselective electrooxidative heterocoupling of two different enamines is reported for the synthesis of unsymmetrically substituted NH-pyrroles. A “magic effect” of the additive trifluoroethanol is utilized to achieve the desired chemoselectivity by tuning the oxidation potentials and controlling the activation energy of the rate-determining step.
Abstract
An electrochemical method for the synthesis of unsymmetrically substituted NH-pyrroles is described. The synthetic strategy comprises a challenging heterocoupling between two structurally diverse enamines via sequential chemoselective oxidation, addition, and cyclization processes. A series of aryl- and alkyl-substituted enamines were effectively cross-coupled from an equimolar mixture to synthesize various unsymmetrical pyrrole derivatives up to 84 % yield. The desired cross-coupling was achieved by tuning the oxidation potential of the enamines by utilizing a “magic effect” of the additive trifluoroethanol (TFE). Additionally, extensive computational studies reveal the unique role of TFE in promoting the heterocoupling process by regulating the activation energies of the reaction steps through H-bonding and C−H⋅⋅⋅π interactions. Importantly, the developed electrochemical protocol was found to be equally efficient for the homocoupling of enamines to form symmetric pyrroles up to 92 % yield.
05 Dec 22:13
by Yan Huang, Jing Hou, Le-Wu Zhan, Qian Zhang, Wan-Ying Tang, and Bin-Dong Li
ACS Catalysis
DOI: 10.1021/acscatal.1c04684
05 Dec 22:12
by Philippe-Alexandre Poisson, Gaël Tran, Céline Besnard, and Clément Mazet
ACS Catalysis
DOI: 10.1021/acscatal.1c04800
05 Dec 22:06
Green Chem., 2021, Accepted Manuscript
DOI: 10.1039/D1GC03662A, Critical Review
Volker Hessel, Nam Nghiep Tran, Mahdieh Razi Asrami, Quy Don Tran, Van Duc Long Nguyen, Marc Escribà Gelonch, Jose Luis Osorio-Tejada, Steffen Linke, Kai Sundmacher
Solvents define pivotal properties for chemical processing and chemical reactions, and can be as much game-changing as catalysts are. A solvent can be the key to a good chemical process,...
The content of this RSS Feed (c) The Royal Society of Chemistry
MRV and -1 others like this
05 Dec 22:03
by Yichang Liu, Biyin Shi, Zhao Liu, Renfei Gao, Cunlong Huang, Hesham Alhumade, Shengchun Wang, Xiaotian Qi, and Aiwen Lei
Journal of the American Chemical Society
DOI: 10.1021/jacs.1c09341
02 Dec 15:11
by Ephrath Solel, Marcel Ruth, and Peter R. Schreiner
Journal of the American Chemical Society
DOI: 10.1021/jacs.1c09222
30 Nov 13:25
by Matthew C. Leech, Alessia Petti, Nour Tanbouza, Andrea Mastrodonato, Iain C. A. Goodall, Thierry Ollevier, Adrian P. Dobbs, and Kevin Lam
Organic Letters
DOI: 10.1021/acs.orglett.1c03475
21 Nov 08:55
by Christian A. Malapit, Matthew B. Prater, Jaime R. Cabrera-Pardo, Min Li, Tammy D. Pham, Timothy Patrick McFadden, Skylar Blank, and Shelley D. Minteer
Chemical Reviews
DOI: 10.1021/acs.chemrev.1c00614
15 Nov 10:51
by Rolando Cannalire, Federica Santoro, Camilla Russo, Giulia Graziani, Gian Cesare Tron, Alfonso Carotenuto, Diego Brancaccio, and Mariateresa Giustiniano
ACS Organic & Inorganic Au
DOI: 10.1021/acsorginorgau.1c00028
15 Nov 08:48
by Stull, Savannah M.
Synlett
DOI: 10.1055/a-1665-9220
A red-light-mediated [3+2] annulation of cyclopropylamines with akenes or alkynes in the presence of N,N′-dipropyl-1,13-dimethoxyquinacridinium is reported. An array of cyclopentane or cyclopentene derivatives with diverse functional groups have been obtained in moderate to excellent yields under mild conditions.
[...]
Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, Germany
Article in Thieme eJournals:
Table of contents | Abstract | Full text
10 Nov 08:59
by Nicholas E. S. Tay, Dan Lehnherr, and Tomislav Rovis
Chemical Reviews
DOI: 10.1021/acs.chemrev.1c00384
06 Nov 18:08
by Wang Yao,
Emmanuel A. Bazan-Bergamino,
Ming-Yu Ngai
Asymmetric photocatalysis: This review provides a current overview of visible-light-induced asymmetric photocatalysis enabled by chiral organocatalysts. Innovative approaches including mono- and dual-catalysis are discussed. Chiral organocatalysis such as enamine catalysis, iminium-ion catalysis, Brønsted acid/base catalysis, and N-heterocyclic carbene catalysis have been exploited to induce chirality transfer of photocatalytic reactions. We hope that this review will spark new ideas for designing novel strategies in the field of asymmetric photocatalysis.
Abstract
Visible-light photocatalysis has advanced as a versatile tool in organic synthesis. However, attaining precise stereocontrol in photocatalytic reactions has been a longstanding challenge due to undesired photochemical background reactions and the involvement of highly reactive radicals or radical ion intermediates generated under photocatalytic conditions. To address this problem and expand the synthetic utility of photocatalytic reactions, a number of innovative strategies, including mono- and dual-catalytic approaches, have recently emerged. Of these, exploiting chiral organocatalysis, such as enamine catalysis, iminium-ion catalysis, Brønsted acid/base catalysis, and N-heterocyclic carbene catalysis, to induce chirality transfer of photocatalytic reactions has been widely explored. This Review aims to provide a current, comprehensive overview of asymmetric photocatalytic reactions enabled by chiral organocatalysts published through June 2021. The substrate scope, advantages, limitations, and proposed reaction mechanisms of each reaction are discussed. This review should serve as a reference for the development of visible-light-induced asymmetric photocatalysis and promote the improvement of the chemical reactivity and stereoselectivity of these reactions.
06 Nov 18:07
by Phan T. Truong,
Sophia G. Miller,
Emily J. McLaughlin Sta. Maria,
Miriam A. Bowring
Hydrogen atoms sometimes react far faster than deuterium atoms. Reactions can proceed over 100 times faster with hydrogen, or the deuterium reaction may not be observed at all. Examples of large kinetic isotope effects throughout organotransition metal chemistry are reviewed. Possible causes for these observed effects are discussed, including vibrational differences, multistep reactions, and proton tunneling. Artwork depicting a hydrogen cheetah and a deuterium sloth by Caitlyn Y. Tong. Read more in the Minireview by M. A. Bowring et al. on page 14800 ff.
06 Nov 17:30
by Bholanath Maity, Chen Zhu, Magnus Rueping, and Luigi Cavallo
ACS Catalysis
DOI: 10.1021/acscatal.1c04142
06 Nov 17:24
by Marin Kemmochi,
Yusuke Miyamoto,
Yuto Sumida,
Hirohisa Ohmiya
The photoexcitable borate enabling Minisci alkylation of heteroarene has been described. This protocol using alkylborate only needed O2 and visible light, which provides a considerably clean system. The direct photoexcitation of alkylborate allowed the generation of tertiary, secondary, and primary-alkyl radical including methyl radical.
Abstract
The photoexcitable borate enabling Minisci C−H alkylation of heteroarene has been described. This protocol using alkylborate only needed O2 and visible light, which provides a considerably clean system. The direct photoexcitation of alkylborate allowed the generation of tertiary, secondary, and primary-alkyl radical including methyl radical. This light-driven Minisci reaction gave a choice for the functionalization of heteroarenes.
06 Nov 17:17
by Florian S. Tschernuth,
Thaddäus Thorwart,
Lutz Greb,
Franziska Hanusch,
Shigeyoshi Inoue
A novel Si-based Lewis superacid was synthesized by using highly electron-withdrawing perfluoropinacolato substituents. The formed silane was obtained as the acetonitrile mono-adduct and comprehensively characterized. The reaction with Et3SiF led to fluoride abstraction yielding the anionic fluorosilicate and the acetonitrile stabilized silylium ion. Catalysis screenings demonstrated high activity in Lewis acid catalyzed reactions.
Abstract
Despite the earth abundance and easy availability of silicon, only few examples of isolable neutral silicon centered Lewis superacids are precedent in the literature. To approach the general drawbacks of limited solubility and unselective deactivation pathways, we introduce a Lewis superacid, based on perfluorinated pinacol substituents. The compound is easily synthesized on a gram-scale as the corresponding acetonitrile mono-adduct 1⋅(MeCN) and was fully characterized, including single crystal X-ray diffraction analysis (SC-XRD) and state-of-the-art computations. Lewis acidity investigations by the Gutmann-Beckett method and fluoride abstraction experiments indicate a Lewis superacidic nature. The challenging Si−F bond activation of Et3SiF is realized and promising catalytic properties are demonstrated, consolidating the potential applicability of silicon centered Lewis acids in synthetic catalysis.