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09 Dec 06:56

Immunoglobulin knockout chickens [Genetics]

by Schusser, B., Collarini, E. J., Yi, H., Izquierdo, S. M., Fesler, J., Pedersen, D., Klasing, K. C., Kaspers, B., Harriman, W. D., van de Lavoir, M.-C., Etches, R. J., Leighton, P. A.
Gene targeting by homologous recombination or by sequence-specific nucleases allows the precise modification of genomes and genes to elucidate their functions. Although gene targeting has been used extensively to modify the genomes of mammals, fish, and amphibians, a targeting technology has not been available for the avian genome. Many of...