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Discovery of (R)-1-(3-(4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-(dimethylamino)ethanone (CHMFL-FLT3-122) as a Potent and Orally Available FLT3 Kinase Inhibitor for FLT3-ITD Positive Acute Myeloid Leukemia
Cover Picture: An Experimental and Theoretical Investigation on Pentacoordinated Cobalt(III) Complexes with an Intermediate S=1 Spin State: How Halide Ligands Affect their Magnetic Anisotropy (Chem. Eur. J. 3/2016)
A series of mononuclear penta-coordinated halide CoIII complexes with intermediate S=1 spin state has been investigated. Their magnetic anisotropy is sensitive to the nature of the halide in an unexpected way: the largest value was found for the chloride compound and the smallest for the iodide one. This study evidences that contemporary computational methods are powerful tools to predict and rationalize the magnetic anisotropy in such systems. However, for each metal ion, at each oxidation and spin state, benchmark studies are required to define magneto-structural correlations. The authors gratefully thank Dr. Sylvain Bertaina for his assistance in the design of the cover illustration. More information can be found in the Full Paper by M. Orio, C. Duboc et al. on page 925 ff.