Jack Sutro

Nature Communications, Published online: 04 December 2025; doi:10.1038/s41467-025-66895-2

DNA G-quadruplexes help regulate genes, but their strand-specific roles are unclear. Here, the authors develop ssG4-seq to map G4s genome-wide, showing abundant enhancer- and promoter-localised structures that activate transcription via SP1 and are disrupted by cancer-linked mutations.

Nature, Published online: 01 December 2025; doi:10.1038/d41586-025-03805-y

Two studies suggest that T cells with stem-cell-like properties could work with antibody therapies to control HIV after a person stops taking antiviral pills.