Biocatalysis@TUDelft

Nature Chemical Biology, Published online: 27 January 2025; doi:10.1038/s41589-024-01818-8

Iron–sulfur clusters are essential protein cofactors synthesized through a complex sequential process. Here the authors show that the assembly of [2Fe–2S] clusters by the iron–sulfur cluster assembly machinery proceeds by the formation and fusion of [1Fe–1S] intermediates in the IscU scaffold protein.

Nature Chemistry, Published online: 06 March 2025; doi:10.1038/s41557-025-01759-2

There are many steps to preparing a research article for publication, from generating the figures and writing the draft, to responding to reviewers. Shira Joudan explains how their group approaches this task, specifically during the preparation of the research group’s first paper.

Nature Catalysis, Published online: 29 January 2025; doi:10.1038/s41929-025-01290-0

Enzymatic catalysis meets radical coupling

Nature Catalysis, Published online: 28 January 2025; doi:10.1038/s41929-024-01281-7

H2O2-dependent haem-peroxygenase-catalysed C–H bond oxyfunctionalization reactions have attracted much attention, but elevated concentrations of H2O2 are detrimental to the enzyme. Now, it is reported that this biocatalyst can operate via an alternative pathway using O2 and small-molecule reductants.

Nature Catalysis, Published online: 06 February 2025; doi:10.1038/s41929-025-01294-w

Iminium-catalysed cycloaddition is a prominent example of organocatalytic reactivity, yet a biological counterpart has not been identified. Now, the authors report biochemical, structural and computational evidence for iminium catalysis by the natural Diels–Alderase SdnG.