The Front Cover illustrates the confluence of theory and experiment in determining the state of the equilibrium between tautomers of pyridone nucleobase analogs. The Research Article by C. Richert and co-workers (DOI: 10.1002/ejoc.202401384) reports on substituent effects on this equilibrium and delves into both quantum-chemical and spectroscopic methods for prediction of this property. The background picture was taken by Dragoş Merişcaore.