Alexandre Hautier

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30 Jun 09:48

Enantioselective Chemo- and Biocatalysis: Partners in Retrosynthesis

Enantioselective Chemo‐ and Biocatalysis: Partners in Retrosynthesis

Partners in synthesis: This Review provides a guide to the use of biocatalytic methods in the area of chemical synthesis with focus on retrosynthetic considerations and analysis. It is expected to lead to better understanding of the characteristics and distinctions of the two complementary approaches by depicting a road map of challenges and opportunities for the evolution in chemical synthesis.

[Review]
Moritz Hönig, Philipp Sondermann, Nicholas J. Turner, Erick M. Carreira
Angew. Chem. Int. Ed., June 26, 2017, https://doi.org/10.1002/anie.201612462 Read article

31 May 08:57

Design of peptide-containing N5-unmodified neutral flavins that catalyze aerobic oxygenations

Chem. Sci., 2017, 8,5468-5475
DOI: 10.1039/C7SC01933E, Edge Article
Open Access Open Access
Creative Commons Licence&nbsp This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Yukihiro Arakawa, Ken Yamanomoto, Hazuki Kita, Keiji Minagawa, Masami Tanaka, Naoki Haraguchi, Shinichi Itsuno, Yasushi Imada
The first flavoenzyme-mimetic aerobic oxygenations catalyzed by N5-unmodified neutral flavin were realized with flavopeptides (Fl-Pep) rationally designed by computational calculations.
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25 Apr 14:07

Unclicking the Click: Metal-Assisted Mechanochemical Cycloreversion of Triazoles is Possible

Unclicking the Click: Metal‐Assisted Mechanochemical Cycloreversion of Triazoles is Possible

Mechanochemical unclicking reactions of 1,2,3-triazoles have been a topic of controversy. Based on isotensional quantum-chemical calculations, it is shown that their 1,5-regioisomers easily undergo cycloreversion reactions under standard sonication conditions if they are RuII catalyzed.

[Communication]
Martin Krupička, Przemyslaw Dopieralski, Dominik Marx
Angew. Chem. Int. Ed., April 24, 2017, https://doi.org/10.1002/anie.201612507 Read article