Journal of the American Chemical Society
DOI: 10.1021/jacs.7b02869
Shared posts
03 Jun 02:11
Ultrafast Spectroscopy Reveals Electron-Transfer Cascade That Improves Hydrogen Evolution with Carbon Nitride Photocatalysts
by Kathryn L. Corp and Cody W. Schlenker
qinyuchen, ylm0809185 and 6 others like this
10 Apr 00:44
Exploring the Chemistry of Genetic Information Storage and Propagation through Polymerase Engineering
by Gillian Houlihan, Sebastian Arangundy-Franklin and Philipp Holliger
Accounts of Chemical Research
DOI: 10.1021/acs.accounts.7b00056
yunerjiejie, Soumen Ghosh likes this
15 Feb 11:57
Inside Cover: In Vivo Dearomatization of the Potent Antituberculosis Agent BTZ043 via Meisenheimer Complex Formation (Angew. Chem. Int. Ed. 8/2017)
Nitrobenzothiazinones are highly potent antibiotics against Mycobacterium tuberculosis. While their killing mechanism involves the reduction of the nitro to a reactive nitroso group, F. Kloss and co-workers describe in their Communication on page 2187 ff. a previously overlooked in vivo bioreduction pathway. The metabolites are transient hydride Meisenheimer complexes that are readily reoxidized under atmospheric conditions and completely unprecedented among drug metabolites.
[Cover Picture]
Florian Kloss, Viktor Krchnak, Anna Krchnakova, Sebastian Schieferdecker, Julia Dreisbach, Volker Krone, Ute Möllmann, Michael Hoelscher, Marvin J. Miller
Angew. Chem. Int. Ed., January 26, 2017, DOI: 10.1002/anie.201700069. Read article
No more posts. Check out what's trending.