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18 Aug 08:47

Filling of a water-free void explains the allosteric regulation of the β1-adrenergic receptor by cholesterol

by Layara Akemi Abiko

Nature Chemistry, Published online: 11 August 2022; doi:10.1038/s41557-022-01009-9

The β1-adrenergic receptor (β1AR) contains empty cavities in its preactive conformation, which disappear in the active one. Now, using X-ray crystallography of xenon-derivatized β1AR crystals, a cavity has been shown to be in contact with the cholesterol-binding pocket. Monitoring the binding of a cholesterol analogue in solution has explained the function of cholesterol as a negative allosteric modulator of β1AR.
20 Aug 19:01

[ASAP] Photochemical Solid-Phase Synthesis of Platinum Single Atoms on Nitrogen-Doped Carbon with High Loading as Bifunctional Catalysts for Hydrogen Evolution and Oxygen Reduction Reactions

by Tuanfeng Li, Jingjun Liu, Ye Song, Feng Wang

TOC Graphic

ACS Catalysis
DOI: 10.1021/acscatal.8b02288
06 Sep 11:13

Crystalline nickel manganese antimonate as a stable water-oxidation catalyst in aqueous 1.0 M H2SO4

Energy Environ. Sci., 2017, 10,2103-2108
DOI: 10.1039/C7EE01486D, Communication
Ivan A. Moreno-Hernandez, Clara A. MacFarland, Carlos G. Read, Kimberly M. Papadantonakis, Bruce S. Brunschwig, Nathan S. Lewis
NixMn1-xSb1.6-1.8Oy acts as a stable OER electrocatalyst for >168 h of operation in 1.0 M sulfuric acid.
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