This little monkey is trying her hardest to train a limp-limbed human how to crack open a nut with a rock. When she realizes the human isn't making much of an effort, she looks up with an expression that says, "Wtf‽ Help me out here, hairless ape covered in fibers!"
Similarly: Monkey teaches human how to crush leaves
N-Heterocyclic carbene (NHC) catalysis has emerged as a powerful stratagem in organic synthesis to construct complex molecules primarily by polarity reversal (umpolung) approaches. These unique Lewis bases have been used to generate acyl anions, enolates, and homoenolates in catalytic fashion. Recently, a new strategy has emerged that dramatically expands the synthetic utility of carbene catalysis by leveraging additional activation modes: cooperative catalysis. The careful selection and balance of cocatalysts have led to enhanced reactivity, increased yields, and improved stereoselectivity. In certain cases, these catalytic additives have changed the regioselectivity or diastereoselectivity. This Minireview highlights new advances in NHC cooperative catalysis and surveys the evolution of this field.
N-Heterocyclic carbene (NHC) catalysis is a versatile and powerful strategy to construct complex molecules. To extend and enhance the reactivity of these nucleophiles, cooperative catalysis and related activation approaches have been developed by integrating complementary modes (Lewis/Brønsted acidity, transition-metal processes, photoredox). Recent contributions are summarized in this Minireview.
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Japanese hand planes or kannas are remarkable tools that can shave off layers of wood so ridiculously thin that they look like tissue paper. The wood shaving in the GIF above is only 8 microns thick which almost sounds like an impossible measurement because even human hair has a diameter of about 50 microns.
Donald Trump refused to say he would honor election results and was unsuccessful in changing the narrative that is enveloping his campaign. Hillary Clinton fired as many taunts as Trump landed blows.
A system consisting of catalytic amounts of [(p-cym)RuCl2]2/PEt3⋅HBF4, K2CO3 as the base, and NMP as the solvent efficiently mediates the ortho-C−H arylation of benzoic acids with aryl bromides at 100 °C. Replacing the phosphine ligand with the amino acid dl-pipecolinic acid enables the analogous transformation with aryl chlorides. The key advantage of this broadly applicable transformation is the use of an inexpensive ruthenium catalyst in combination with simple carboxylates as directing groups, which can either be tracelessly removed or used as anchor points for decarboxylative ipso substitutions.
Bromides and chlorides: A system consisting of [(p-cym)RuCl2]2/PEt3⋅HBF4 as the catalyst, K2CO3 as the base, and NMP as the solvent efficiently mediates the ortho-C−H arylation of benzoic acids with aryl bromides at 100 °C. Replacing the phosphine ligand with the amino acid dl-pipecolinic acid enables the analogous transformation with aryl chlorides.
Read more of this story at Slashdot.
Magic is mostly just how good you are with your hands. Here are three really easy magic tricks that you can pull with just a pen: making it disappear, making it appear out of nowhere, and making it look super small. Oscar Owen breaks down the techniques for each and they only involve super quick finger movements. The alternate angle reveals how easy it is.
You don’t need a comprehensive understanding of how a car works to enjoy one. (Though I think it does help.) Anybody can make their car a lot safer and likely longer-lasting by paying attention to just a few key things, as this video runs through.
Twitter, Spotify and Reddit, and a huge swath of other websites were down or screwed up this morning. This was happening as hackers unleashed a large distributed denial of service (DDoS) attack on the servers of Dyn, a major DNS host. It’s probably safe to assume that the two situations are related.