21 Apr 16:00

Childless

21 Apr 11:22

Trying to Have a Sex Life With Kids Summarized in One gif

Submitted by: (via Giphy)

Tagged: FAIL , gifs
21 Apr 05:03

Comic for April 21, 2017

Dilbert readers - Please visit Dilbert.com to read this feature. Due to changes with our feeds, we are now making this RSS feed a link to Dilbert.com.
21 Apr 07:28

Survivorship Bias

They say you can't argue with results, but what kind of defeatist attitude is that? If you stick with it, you can argue with ANYTHING.
21 Apr 15:34

N-Heterocyclic Carbene Catalyzed [4+2] Annulation of Enals via a Double Vinylogous Michael Addition: Asymmetric Synthesis of 3,5-Diaryl Cyclohexenones

by Xiang-Yu Chen, Qiang Liu, Pankaj Chauhan, Sun Li, Anssi Peuronen, Kari Rissanen, Ehsan Jafari, Dieter Enders

Abstract

A strategy for the N-heterocyclic carbene (NHC) catalyzed asymmetric synthesis of 3,5-diaryl substituted cyclohexenones has been developed via oxidative [4+2] annulation of enals and alkenylisoxazoles. It is the first example of using NHC organocatalysis in a double vinylogous Michael type reaction, a challenging but highly desirable topic. This unprecedented protocol affords good yields as well as high to excellent diastereo- and enantioselectivities.

Thumbnail image of graphical abstract

N-heterocyclic carbene organocatalysis allows the [4+2] annulation of enals with electron-deficient 2,4-dienes via a double vinylogous Michael addition sequence. The corresponding 3,5-diaryl cyclohexenones are obtained in good to excellent yields with high to excellent diastereo- and enantioselectivities.

21 Apr 02:07

Lethbridge police patrols targeting increased outdoor sex incidents

by Bryan Passifiume

With spring in the air and one’s thoughts naturally turning to those of romantic rendezvous, police in Lethbridge kindly ask they not take place in city greenspaces.

Complaints of couples engaging in sexual acts along the Old Man river valley have reached what police are calling chronic levels, prompting officials to increase patrols in the greenspaces surrounding the Elks Compound near Fort Whoop-Up.

City crews are also engaged in removing trees and cutting brush in an attempt to deter the activity, which often takes place in full view of both park visitors and the police. 

Couples caught in coitus have so far been issued warnings by officers, but police warn criminal charges may be laid if the outdoor dalliances continue.

Anybody who observes lewd conduct in any public place is asked to call Lethbridge police at 403-328-4444.

bpassifiume@postmedia.com

Twitter/bryanpassifiume

21 Apr 07:37

The Campaign: Against The Clock

by Tim

Since Four will have a limited role to play in this story (on account of being comatose due to poison), I thought I’d at least let her be a pain in the ass at the table.

21 Apr 05:29

Girl Genius for Friday, April 21, 2017

The Girl Genius comic for Friday, April 21, 2017 has been posted.
22 Apr 01:21

Identifying the Active Surfaces of Electrochemically Tuned LiCoO2 for Oxygen Evolution Reaction

by Zhiyi Lu, Guangxu Chen, Yanbin Li, Haotian Wang, Jin Xie, Lei Liao, Chong Liu, Yayuan Liu, Tong Wu, Yuzhang Li, Alan C. Luntz, Michal Bajdich and Yi Cui

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.7b02622
21 Apr 00:40

Preoccupancy

21 Apr 14:03

Friday Link Pack

by swissmiss

– Break the binge: How to turn off autoplay for the next episode on Netflix. (via)

How to Make the Most of Your Workday

Climate March is happening on April 29th

Feminist pin.

– Fire Drills: Communications Strategy in a Crisis

– My kind of gun.

– Really cute Kids Travel Blankets.

How To Cook Asparagus

May you feel awesome like this.

World’s “Mattest and Flattest” Black Paint

– “Both the military and professional kitchens are environments where there’s zero tolerance for slackers and indecision” – Why Chefs and Soldiers Make the Best Product Managers

– This is a smart coat for airplane travel.

– This tray!

– The short doc The Culture of Proximity digs into the notion that millennials see themselves as creators as much as consumers. (via)

– Want to convince someone to help you with a project? Try the bingo method.

Dragons love tacos is one of my son’s favorite picture books. I just noticed there’s a sequel!

The new Google Earth

Ways to Use Leftover Eggshells

– Ms. Management: The Hard Work of Hiring Well (via)

Setting intentions versus goals.

– Some of these signs made me laugh out loud.

The Faces behind Craigslist’s “Strictly Platonic” Personal Ads

– I heard this book helps you teach your kids about money. I’ll order it and will see for myself.

What it means to be a seeker

How Often You Should Do 12 Household Chores

– Here’s something to try at home: 6 fun activities to introduce your kids to physics!

How to keep your iMessages from popping up on other devices

– Made me laugh: IKEA “Relationship Saving Station

– Stina Persson’s watercolor Tattly collection now includes a Panda!

22 Apr 05:03

Competitive

by David M Willis

Just three-ish days left in the Dumbing of Age Book 6 Kickstarter, and here’s Sal, the final, thirteenth magnet for the Kickstarter!

Remember, there are PICK THREE MAGNETS and now PICK FIVE MAGNETS pledge tiers, where you can choose which three or five magnets you want, PLUS the bonus Becky magnet everyone (with a real paper book) gets.  So if you want a Sal, there’s a good chance there’s a way to add her.

21 Apr 09:08

In Situ Construction of Stable Tissue-Directed/Reinforced Bifunctional Separator/Protection Film on Lithium Anode for Lithium–Oxygen Batteries

by Ji-Jing Xu, Qing-Chao Liu, Yue Yu, Jin Wang, Jun-Min Yan, Xin-Bo Zhang

To achieve a high reversibility and long cycle life for Li–O2 battery system, the stable tissue-directed/reinforced bifunctional separator/protection film (TBF) is in situ fabricated on the surface of metallic lithium anode. It is shown that a Li–O2 cell composed of the TBF-modified lithium anodes exhibits an excellent anodic reversibility (300 cycles) and effectively improved cathodic long lifetime (106 cycles). The improvement is attributed to the ability of the TBF, which has chemical, electrochemical, and mechanical stability, to effectively prevent direct contact between the surface of the lithium anode and the highly reactive reduced oxygen species (Li2O2 or its intermediate LiO2) in cell. It is believed that the protection strategy describes here can be easily extended to other next-generation high energy density batteries using metal as anode including Li–S and Na–O2 batteries.

Thumbnail image of graphical abstract

The stable tissue-directed/reinforced bifunctional separator/protection film (TBF) is in situ fabricated on the surface of metallic lithium anode. The Li–O2 battery cell with the TBF-modified lithium anodes exhibits an excellent anodic reversibility and effectively improved cathodic long lifetime.

21 Apr 17:03

The Moldy Foods You Can and Can't Eat

by Thorin Klosowski

When you find a bit of mold on food, it might seem like it’s okay to salvage some of it because the mold doesn’t cover the whole thing. That seems like the logical step, right? It turns out that’s not true for a lot of foods, like bread, because the mold can hide deep in the surface where you can’t see it.

Read more...

21 Apr 16:50

Saturday Morning Breakfast Cereal - The Interpretation of Hats

by tech@thehiveworks.com


Click here to go see the bonus panel!

Hovertext:
Now to spray sweet white flowers out of this big long wand.

New comic!
Today's News:

Hey geeks! I'll be signing this Sunday at the MIT Press Bookstore from 3-430, and then again after BAHFest. Come say hi!

21 Apr 15:34

Palladium-Catalyzed Carbonylation of sec- and tert-Alcohols

by Kaiwu Dong, Rui Sang, Jie Liu, Rauf Razzaq, Robert Franke, Ralf Jackstell, Matthias Beller

Abstract

A general palladium-catalyzed synthesis of linear esters directly from sec- and tert-alcohols is described. Compared to the classic Koch–Haaf reaction, which leads to branched products, this new transformation gives the corresponding linear esters in high yields and selectivity. Key for this protocol is the use of an advanced palladium catalyst system with L2 (pytbpx) as the ligand. A variety of aliphatic and benzylic alcohols can be directly used and the catalyst efficiency for the benchmark reaction is outstanding (turnover number up to 89 000).

Thumbnail image of graphical abstract

Ligands with built-in function make possible the first general carbonylation of tert- and sec-alcohols to give the linear esters. The reactions complement the classic Koch–Haaf carbonylation. A variety of aliphatic and benzylic alcohols can be directly used.

21 Apr 14:29

Comic: Evolution

by Tycho@penny-arcade.com (Tycho)
New Comic: Evolution
23 Apr 06:31

Ravine

by David M Willis
21 Apr 10:15

Tuning Energy Levels without Negatively Affecting Morphology: A Promising Approach to Achieving Optimal Energetic Match and Efficient Nonfullerene Polymer Solar Cells

by Jianquan Zhang, Kui Jiang, Guofang Yang, Tingxuan Ma, Jing Liu, Zhengke Li, Joshua Yuk Lin Lai, Wei Ma, He Yan

One advantage of nonfullerene polymer solar cells (PSCs) is that they can yield high open-circuit voltage (VOC) despite their relatively low optical bandgaps. To maximize the VOC of PSCs, it is important to fine-tune the energy level offset between the donor and acceptor materials, but in a way not negatively affecting the morphology of the donor:acceptor (D:A) blends. Here, an effective material design rationale based on a family of D–A1–D–A2 terthiophene (T3) donor polymers is reported, which allows for the effective tuning of energy levels but without any negative impacts on the morphology of the blend. Based on a T3 donor unit combined with difluorobenzothiadiazole (ffBT) and difluorobenzoxadiazole (ffBX) acceptor units, three donor polymers are developed with highly similar morphological properties. This is particularly surprising considering that the corresponding quaterthiophene polymers based on ffBT and ffBX exhibit dramatic differences in their solubility and morphological properties. With the fine-tuning of energy levels, the T3 polymers yield nonfullerene PSCs with a high efficiency of 9.0% for one case and with a remarkably low energy loss (0.53 V) for another polymer. This work will facilitate the development of efficient nonfullerene PSCs with optimal energy levels and favorable morphology properties.

Thumbnail image of graphical abstract

A terthiophene-based donor polymer PffBTBX-T3 with the D–A1–D–A2 structure is demonstrated and compared with the other two D–A-type polymers PffBT-T3 and PffBX-T3. While the energy levels of three polymers are fine-tuned, their optical and morphological pro­perties are not dramatically changed. The optimal energetic match and well-controlled morphology enable 9.0% effi­cient nonfullerene devices based on PffBTBX-T3 and ITIC-Th.

21 Apr 18:34

Saturday Morning Breakfast Cereal - The Interpretation of Hats

by tech@thehiveworks.com


Click here to go see the bonus panel!

Hovertext:
Now to spray sweet white flowers out of this big long wand.

New comic!
Today's News:

Hey geeks! I'll be signing this Sunday at the MIT Press Bookstore from 3-430, and then again after BAHFest. Come say hi!

21 Apr 15:34

Layered Double Hydroxide Nanosheets with Multiple Vacancies Obtained by Dry Exfoliation as Highly Efficient Oxygen Evolution Electrocatalysts

by Yanyong Wang, Yiqiong Zhang, Zhijuan Liu, Chao Xie, Shi Feng, Dongdong Liu, Mingfei Shao, Shuangyin Wang

Abstract

Layered double hydroxides (LDHs) with two-dimensional lamellar structures show excellent electrocatalytic properties. However, the catalytic activity of LDHs needs to be further improved as the large lateral size and thickness of the bulk material limit the number of exposed active sites. However, the development of efficient strategies to exfoliate bulk LDHs into stable monolayer LDH nanosheets with more exposed active sites is very challenging. On the other hand, the intrinsic activity of monolayer LDH nanosheets can be tuned by surface engineering. Herein, we have exfoliated bulk CoFe LDHs into ultrathin LDH nanosheets through Ar plasma etching, which also resulted in the formation of multiple vacancies (including O, Co, and Fe vacancies) in the ultrathin 2D nanosheets. Owing to their ultrathin 2D structure, the LDH nanosheets expose a greater number of active sites, and the multiple vacancies significantly improve the intrinsic activity in the oxygen evolution reaction (OER).

Thumbnail image of graphical abstract

Thinner and thinner: The dry exfoliation of bulk CoFe layered double hydroxides into ultrathin nanosheets with multiple vacancies was achieved by argon plasma etching to disrupt the intrinsic interlayer electrostatic interactions. These nanosheets are superior electrocatalysts for the oxygen evolution reaction.

21 Apr 21:08

Why Does Every Car Infotainment System Look So Crappy?

by Thorin Klosowski

User interface design is hard, but we’ve been getting better at it over the years to the point where even a thermostat is easy to use. Automakers, however, seem to have their heads in the sand, taking their design inspiration for their infotainment consoles from old Winamp skins instead of any type of modern interface.

Read more...

21 Apr 15:34

Enantioselective Silver and Amine Co-catalyzed Desymmetrizing Cycloisomerization of Alkyne-linked Cyclohexanones

by Rubén Manzano, Swarup Datta, Robert S. Paton, Darren J. Dixon

Abstract

A silver(I) and amine co-catalyzed desymmetrization of 4-propargylamino cyclohexanones for the direct enantioselective synthesis of 2-azabicyclo[3.3.1]nonanes is described. Exploiting reactivity arising from dual activation of the pendant terminal alkyne by silver(I) and the ketone moiety through transient enamine formation, this synthetically relevant transformation is easy to perform, efficient and broad in scope. High enantioselectivity (up to 96 % ee) was achieved by exploiting a significant matching effect between the chirality of a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylpyrrolidine catalyst which was rationalized by DFT calculations. This allowed for the preparation of both enantiomers of the bicyclic product with near-identical stereocontrol.

Thumbnail image of graphical abstract

A matching effect between a chiral aminocatalyst and a chiral ligand for silver is exploited in the title reaction of 4-propargylamino cyclohexanones for the direct enantioselective synthesis of 2-azabicyclo[3.3.1]nonanes. The reaction is efficient, broad in scope and proceeds with high enantioselectivity.

23 Apr 05:01

Comic for April 23, 2017

Dilbert readers - Please visit Dilbert.com to read this feature. Due to changes with our feeds, we are now making this RSS feed a link to Dilbert.com.
21 Apr 15:34

Base-Controlled Completely Selective Linear or Branched Rhodium(I)-Catalyzed C−H ortho-Alkylation of Azines without Preactivation

by Gaël Tran, Kevin D. Hesp, Vincent Mascitti, Jonathan A. Ellman

Abstract

A [RhI]/bisphosphine/base catalytic system for the ortho-selective C−H alkylation of azines by acrylates and acrylamides is reported. This catalytic system features an unprecedented complete linear or branched selectivity that is solely dependent on the catalytic base that is used. Complete branched selectivity is even achieved for ethyl methacrylate, which enables the introduction of a quaternary carbon center. Excellent functional group compatibility is demonstrated for both linear and branched alkylations. The operational simplicity and broad scope of this transformation allow for rapid access to functionalized azines of direct pharmaceutical and agrochemical relevance.

Thumbnail image of graphical abstract

A basic choice: The linear/branched selectivity of an ortho-selective C−H alkylation of azines without preactivation is completely controlled by a simple switch between base catalysts. Under the “branched” conditions even quaternary carbon centers can be introduced. Excellent functional group compatibility is demonstrated for both linear and branched alkylations with acrylate derivatives.