16 Mar 03:24

Pi From Scratch

16 Mar 12:21


by Tracy
16 Mar 09:51

Comic: The Hierarchy

by Tycho@penny-arcade.com (Tycho)
New Comic: The Hierarchy
14 Mar 17:34

Saturday Morning Breakfast Cereal - God

by tech@thehiveworks.com

Click here to go see the bonus panel!

Please read today's blog.

New comic!
Today's News:

Hey geeks, my nephew has gone missing as of last Saturday. He's 15, 6'2", probably in Massachusetts, probably in the Framinham or Dorchester area. We are very worried and upset - if you could please share this link, we would very much appreciate it.

No photo available

14 Mar 18:31

Ring expansion and re-contraction for the synthesis of 1-aryl tetrahydroisoquinolines and tetrahydrobenzazepines from readily available heterocyclic precursors

by Jessica Hill, Johnathan Matlock, Quentin Lefebvre, Katie Cooper, Jonathan Clayden

Tetrahydroisoquinolines and tetrahydrobenzazepines are prepared by acid-promoted ring contraction of cyclic ureas, themselves formed by ring expansion of indolines and tetrahydroquinolines. The consequent overall one-carbon insertion reaction gives these 6- and 7-membered heterocyclic scaffolds in three steps from readily available precursors. Other ring sizes may be formed by an alternative elimination reaction of bicyclic structures. Scalability of the method was demonstrated by operating it in a flow system.

14 Mar 07:04

UFO Disclosure Group Releases Newest Navy F/A-18 Super Hornet UFO Encounter Video

by BeauHD
alaskana98 writes: CNN and other media outlets are reporting that the "To The Stars Academy of Arts and Science" group has released the third in a series of videos purportedly showing an encounter between Navy F/A-18 Super Hornet pilots and an object moving at seemingly impossible speeds off the East Coast of the United States. The video was captured by the Raytheon: Advanced Targeting Forward-Looking Infrared (ATFLIR) pod and includes audio of the pilots excitedly observing this object from far above as it zooms over the ocean surface. The ATFLIR system has trouble getting a lock on the object at first but then gets a lock on it eventually demonstrating that whatever this this was it wasn't a figment of the pilots imaginations. If the video is authentic there are indeed some strange things flying in our skies. The video can be viewed here.

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14 Mar 07:19

Comic: 2018-03-14

New Comic: 2018-03-14
14 Mar 18:10

If Nothing Else, “Fantastic Beasts: The Crimes of Grindelwald” Will Give Us Costume Porn

by Tom and Lorenzo

We’d hardly call ourselves hardcore Potterverse fans, but it seems to us there’s more than a bit of fan unrest regarding this picture. From the apparent light de-gaying of the Dumbledore character to the rather poor attempts at explaining why the film cast Johnny Depp in the title role, it feels more and more like this one’s coming out of the gate with a strong headwind against it.

We can’t say we have strong feelings about it either way, since the first Fantastic Beasts film was little more than a charming bit of forgettable fantasy, from where we were sitting. But no matter how ambivalent we may have been about the sequel or how irritating we tend to find Eddie Redmayne or how questionable we find the appeal of Johnny Depp…






…it sure is pretty to look at.

What can we say? That lovely clash of early 20th Century clothing styles with fantasy design tropes is our costume design sweet spot. It gets us all a-tingle, darlings – but only when it’s done well. Fortunately, they handed the reins over to highly lauded and awarded costume designer Colleen Atwood, who knows a thing or two about how to spin a believable fantasy out of costume design.


Also, Jude Law is looking FOINE, which is a bit of a double-edged sword, because he’s basically Hot, But Sexless Dumbledore in this one, if the rumors are to be believed. Oh, well. We’ll just look at the clothes.


Warner Bros. Pictures’ “Fantastic Beasts: The Crimes of Grindelwald” is the second of five all new adventures in J.K. Rowling’s Wizarding World™.

At the end of the first film, the powerful Dark wizard Gellert Grindelwald (Johnny Depp) was captured by MACUSA (Magical Congress of the United States of America), with the help of Newt Scamander (Eddie Redmayne). But, making good on his threat, Grindelwald escaped custody and has set about gathering followers, most unsuspecting of his true agenda: to raise pure-blood wizards up to rule over all non-magical beings.

In an effort to thwart Grindelwald’s plans, Albus Dumbledore (Jude Law) enlists his former student Newt Scamander, who agrees to help, unaware of the dangers that lie ahead. Lines are drawn as love and loyalty are tested, even among the truest friends and family, in an increasingly divided wizarding world.

The film features an ensemble cast led by Eddie Redmayne, Katherine Waterston, Dan Fogler, Alison Sudol, Ezra Miller, with Jude Law and Johnny Depp. The cast also includes, Zoë Kravitz, Callum Turner, Claudia Kim, William Nadylam, Kevin Guthrie, Carmen Ejogo, and Poppy Corby-Tuech.

“Fantastic Beasts: The Crimes of Grindelwald” is directed by David Yates, from a screenplay by J.K. Rowling. The film is produced by David Heyman, J.K. Rowling, Steve Kloves and Lionel Wigram.

Slated for release on November 16, 2018, the film will be distributed worldwide in 2D and 3D in select theatres and IMAX by Warner Bros. Pictures, a Warner Bros. Entertainment.

[Photo Credit: Jaap Buitendijk/Warner Bros. – Video Credit: via YouTube.com]

The post If Nothing Else, “Fantastic Beasts: The Crimes of Grindelwald” Will Give Us Costume Porn appeared first on Tom + Lorenzo.

14 Mar 23:18

SSSS page 873

Page 873 is up!
14 Mar 19:01

Incorporation of Imidazolium-Based Poly(ionic liquid)s into a Metal–Organic Framework for CO2 Capture and Conversion

by Meili Ding and Hai-Long Jiang

TOC Graphic

ACS Catalysis
DOI: 10.1021/acscatal.7b03404
15 Mar 01:19

Synthesis and Characterization of a Bidirectional Photoswitchable Antagonist Toolbox for Real-Time GPCR Photopharmacology

by Niels J. Hauwert, Tamara A. M. Mocking, Daniel Da Costa Pereira, Albert J. Kooistra, Lisa M. Wijnen, Gerda C. M. Vreeker, Eléonore W. E. Verweij, Albertus H. De Boer, Martine J. Smit, Chris De Graaf, Henry F. Vischer, Iwan J. P. de Esch, Maikel Wijtmans and Rob Leurs

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.7b11422
15 Mar 18:56

The Best Easter Candy and Easter Chocolate, According to Chefs

by Maxine Builder

Though Halloween, with its trick-or-treaters and grab bags of bulk candy, and Valentine’s Day, with its heart-shaped boxes of chocolate, get most of the sugary glory, the truly candy-obsessed know that the best holiday for candy consumption is Easter. (If you don’t believe me, know that in 2016, more Americans bought candy for Easter than for Halloween.) It’s the time for Easter baskets full of chocolate bunnies, chocolate Easter eggs, and, of course, marshmallow Peeps. And to help you find the best Easter chocolate and Easter candy to put in your family’s baskets this year (or your own, we don’t judge), we asked 11 chefs, from New York and Miami, to share their favorite Easter chocolates, candies, and treats.

The Strategist is designed to surface the most useful, expert recommendations for things to buy across the vast e-commerce landscape. Some of our latest conquests include the best dining room decor items, coffee makers, knife sets, Japanese coffee brewer, charcoal water filter, and drinking glasses for water and more. We update links when possible, but note that deals can expire and all prices are subject to change.

Every editorial product is independently selected. If you buy something through our links, New York may earn an affiliate commission.

15 Mar 16:43

The One Thing I Always Do When Guests Come Over

by Caroline Donofrio

The One Thing I Do Before Guests Come Over

Whenever friends stop by, I always do the same thing…

Scent is so important. When it comes to my home, I try my best to make it smell nice.… Read more

The post The One Thing I Always Do When Guests Come Over appeared first on A Cup of Jo.

16 Mar 04:41


by David M Willis
14 Mar 11:39

Toward Superior Capacitive Energy Storage: Recent Advances in Pore Engineering for Dense Electrodes

by Congcong Liu, Xiaojun Yan, Fei Hu, Guohua Gao, Guangming Wu, Xiaowei Yang


With the rapid development of mobile electronics and electric vehicles, future electrochemical capacitors (ECs) need to store as much energy as possible in a rather limited space. As the core component of ECs, dense electrodes that have a high volumetric energy density and superior rate capability are the key to achieving improved energy storage. Here, the significance of and recent progress in the high volumetric performance of dense electrodes are presented. Furthermore, dense yet porous electrodes, as the critical precondition for realizing superior electrochemical capacitive energy, have become a scientific challenge and an attractive research focus. From a pore-engineering perspective, insight into the guidelines of engineering the pore size, connectivity, and wettability is provided to design dense electrodes with different porous architectures toward high-performance capacitive energy storage. The current challenges and future opportunities toward dense electrodes are discussed and include the construction of an orderly porous structure with an appropriate gradient, the coupling of pore sizes with the solvated cations and anions, and the design of coupled pores with diverse electrolyte ions.

Thumbnail image of graphical abstract

Dense yet porous electrodes with high volumetric performance are the key to achieving superior electrochemical capacitive energy storage. Significant research breakthroughs in the volumetric performance of dense electrodes are presented. In particular, an insight into the guidelines of pore engineering is provided, to allow the design of dense electrodes toward high-performance energy storage.

16 Mar 15:51

Saturday Morning Breakfast Cereal - Hey baby

by tech@thehiveworks.com

Click here to go see the bonus panel!

Technically, every time a dog poops it's because of nanomachines.

New comic!
Today's News:

Thanks for sharing, everyone. Jacob has been found safe.

16 Mar 18:34

Robot Future

I mean, we already live in a world of flying robots killing people. I don't worry about how powerful the machines are, I worry about who the machines give power to.
15 Mar 10:05

Strain-promoted cycloaddition of cyclopropenes with o-quinones: a rapid click reaction.

by Han Zuilhof, Digvijay Gahtory, rickdeb Sen, Andriy R Kuzmyn, Jorge Escorihuela

Novel click reactions are of continued interest in fields as diverse as bio-conjugation, polymer science and surface chemistry. Qualification as a proper 'click' reaction requires stringent criteria, including fast kinetics and high conversion, to be met. Herein, we report a novel strain-promoted cycloaddition between cyclopropenes and o-quinones in solution and on a surface. We demonstrate the 'click character' of the reaction in solution and on surfaces for both monolayer and polymer brush functionalization.

15 Mar 07:03

How Amazon Became Corporate America's Nightmare

by BeauHD
Zorro shares a report from Bloomberg that details Amazon's rapid growth in the last three years: Amazon makes no sense. It's the most befuddling, illogically sprawling, and -- to a growing sea of competitors -- flat-out terrifying company in the world. It sells soap and produces televised soap operas. It sells complex computing horsepower to the U.S. government and will dispatch a courier to deliver cold medicine on Christmas Eve. It's the third-most-valuable company on Earth, with smaller annual profits than Southwest Airlines Co., which as of this writing ranks 426th. Chief Executive Officer Jeff Bezos is the world's richest person, his fortune built on labor conditions that critics say resemble a Dickens novel with robots, yet he has enough mainstream appeal to play himself in a Super Bowl commercial. Amazon was born in cyberspace, but it occupies warehouses, grocery stores, and other physical real estate equivalent to 90 Empire State Buildings, with a little left over. The company has grown so large and difficult to comprehend that it's worth taking stock of why and how it's left corporate America so thoroughly freaked out. Executives at the biggest U.S. companies mentioned Amazon thousands of times during investor calls last year, according to transcripts -- more than President Trump and almost as often as taxes. Other companies become verbs because of their products: to Google or to Xerox. Amazon became a verb because of the damage it can inflict on other companies. To be Amazoned means to have your business crushed because the company got into your industry. And fear of being Amazoned has become such a defining feature of commerce, it's easy to forget the phenomenon has arisen mostly in about three years.

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15 Mar 15:26

Addressing Drug Resistance in Cancer with Macromolecular Chemotherapeutic Agents

by Nathaniel H. Park, Wei Cheng, Fritz Lai, Chuan Yang, Paola Florez de Sessions, Balamurugan Periaswamy, Collins Wenhan Chu, Simone Bianco, Shaoqiong Liu, Shrinivas Venkataraman, Qingfeng Chen, Yi Yan Yang and James L. Hedrick

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.7b11468
15 Mar 19:42

“How Stage IV Cancer Taught Me to Live”

by Joanna Goddard

What My Stage IV Cancer Taught Me, by Kate Bowler

When she was 35, Kate Bowler had all she ever wanted: she was a college professor, married to a high-school sweetheart and raising her baby boy.… Read more

The post “How Stage IV Cancer Taught Me to Live” appeared first on A Cup of Jo.

14 Mar 17:25

Monolayer Nanosheets with an Extremely High Drug Loading toward Controlled Delivery and Cancer Theranostics

by Liuqi Peng, Xuan Mei, Jun He, Jiekun Xu, Weiku Zhang, Ruizheng Liang, Min Wei, David G. Evans, Xue Duan


2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd3+-doped monolayered-double-hydroxide (MLDH) nanosheets are prepared via a facile bottom-up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99.67%. This is, as far as it is known, the highest LC level at nearly 100% of EE among previously reported 2D drug delivery systems so far. Interestingly, the as-prepared DOX&ICG/MLDH composite material shows both pH-controlled and near-infrared-irradiation-induced DOX release, which holds a promise in stimulated drug release. An in vivo dual-mode imaging, including near-infrared fluorescence and magnetic resonance imaging, enables a noninvasive visualization of distribution profiles at the tumor site. In addition, in vitro and in vivo therapeutic evaluations demonstrate an excellent trimode synergetic anticancer activity and superior biocompatibility of DOX&ICG/MLDH. Therefore, MLDH nanosheets provide new perspectives in the design of multifunctional nanomedicine, which shows promising applications in controlled drug delivery and cancer theranostics.

Thumbnail image of graphical abstract

Gd3+-doped monolayered-double-hydroxide (MLDH) nanosheets are prepared via a new bottom-up synthesis method followed by the coloading of doxorubicin and indocyanine green, with an ultrahigh drug loading content of 797.36% and encapsulation efficiency of 99.67%. In addition, both in vitro and in vivo studies demonstrate an excellent dual-mode imaging and trimode synergetic therapy toward cancer theranostics.

16 Mar 11:49

How a Norwegian comment section turned chaos into order—with a simple quiz

by Sam Machkovech

AUSTIN, Texas—The five-person team behind a simple WordPress plugin, which took three hours to code, never expected to receive worldwide attention as a result. But NRKbeta, the tech-testing group at Norway's largest national media organization, tapped into a meaty vein with the unveiling of last February's Know2Comment, an open source plugin that can attach to any WordPress site's comment section.

"It was a basic idea," NRKbeta developer Ståle Grut told a South By Southwest crowd on Tuesday. "Readers had to prove they read a story before they were able to comment on it."

The story has since been told a few times, but Grut's recent refresh on the topic is just as compelling for its comment-section impact as it is for NRK's thought process on how to make Internet media a better place: invite readers to have an active stake in improving it.

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15 Mar 21:43

Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs

by Jinxu Gao, Adelphe Mfuh, Yuka Amako and Christina M. Woo

TOC Graphic

Journal of the American Chemical Society
DOI: 10.1021/jacs.7b11639
15 Mar 18:17

Theoretical and Experimental Insight into the Effect of Nitrogen Doping on Hydrogen Evolution Activity of Ni3S2 in Alkaline Medium

by Tianyi Kou, Tyler Smart, Bin Yao, Irwin Chen, David Thota, Yuan Ping, Yat Li


Nickel sulfide (Ni3S2) is a promising hydrogen evolution reaction (HER) catalyst by virtue of its metallic electrical conductivity and excellent stability in alkaline medium. However, the reported catalytic activities for Ni3S2 are still relatively low. Herein, an effective strategy to boost the H adsorption capability and HER performance of Ni3S2 through nitrogen (N) doping is demonstrated. N-doped Ni3S2 nanosheets achieve a fairly low overpotential of 155 mV at 10 mA cm−2 and an excellent exchange current density of 0.42 mA cm−2 in 1.0 m KOH electrolyte. The mass activity of 16.9 mA mg−1 and turnover frequency of 2.4 s−1 obtained at 155 mV are significantly higher than the values reported for other Ni3S2-based HER catalysts, and comparable to the performance of best HER catalysts in alkaline medium. These experimental data together with theoretical analysis suggest that the outstanding catalytic activity of N-doped Ni3S2 is due to the enriched active sites with favorable H adsorption free energy. The activity in the Ni3S2 is highly correlated with the coordination number of the surface S atoms and the charge depletion of neighbor Ni atoms. These new findings provide important guidance for future experimental design and synthesis of optimal HER catalysts.

Thumbnail image of graphical abstract

Nitrogen-doped Ni3S2 nanosheets achieve excellent hydrogen evolution reaction (HER) performance in alkaline media. Both experimental and theoretical investigations suggest that the improved activity of nitrogen-doped Ni3S2 originates from enriched new active sites with favorable H adsorption. These new findings make inexpensive Ni3S2 more attractive and provide important guidance for future experimental design and synthesis of Ni3S2-based HER catalysts.