Shared posts

01 Apr 22:08

The April Fools joke that might have got me fired

by goldenskye
01 Apr 20:57

This Tree Wants to Be Struck by Lightning

by Rebecca Dzombak
Before a discovery in a Panamanian rainforest, “it seemed impossible that lightning could be a good thing for the trees,” a scientist said.
31 Mar 17:43

Traveling to Finland for Lessons on Happiness

by Britta Lokting
Can forest walks, cold plunges and talking to trees make you happier? An anxious American went to Helsinki to see if what she learned there could lift her spirits back home.
31 Mar 05:43

The average college student today

by Jyaif
26 Mar 21:41

Living Car-Free in Arizona, on Purpose and Happily

by Cara Buckley and Rebecca Noble
One community near Phoenix is taking a “completely different” approach to development.
26 Mar 19:14

Goblin.tools: simple, single-task tools to help neurodivergent people with tasks

by ValentineC

Article URL: https://goblin.tools/

Comments URL: https://news.ycombinator.com/item?id=43461375

Points: 338

# Comments: 226

25 Mar 23:26

Hiking the Cactus to Clouds Route in Palm Springs, Calif.

by Dina Mishev and Max Whittaker
The Cactus to Clouds ascent just outside Palm Springs, Calif., is grueling, but natural treasures, and a speedy trip down, await anyone who is up to the challenge.
25 Mar 22:45

“Just ignore him. That’s our rebellious young c...

by tedder

“Just ignore him. That’s our rebellious young calf Matthew—he’s into wearing leather clothes just for the shock value.”
22 Mar 10:10

Everyone in the City Needs Soundproofing, Even Spiders

by Joshua Rapp Learn
Researchers have found evidence that a common North American spider species alters its webs to deal with urban noise pollution.
21 Mar 22:30

Why Lego Is the Hottest Off-Court Obsession in Basketball

by Rose Maura Lorre
An illustration/collage of basketball players and basketball themed legos.

“You play with Lego” is the kind of dig that Myles Turner, the starting center for the NBA’s Indiana Pacers—and, for years, maybe the only guy in the league known for being an AFOL, or Adult Fan of Lego—has heard a lot.

Like in January of this year, after his team traveled to Detroit to take down their Midwestern rivals, the Pistons. As captured by an NBA fan account on YouTube, the buzzer had just sounded on the Pacers’ 111–100 victory when Pistons bench player Isaiah Stewart appeared out of nowhere, wearing a smirk on his face, to mouth those exact words at Turner, with a finger in Turner’s grill.

That was nothing new. Turner’s been hearing some version of that “you play with Lego” remark since around 2018, when he first Instagrammed a video of one of his Lego builds, a 2,000-piece Star Wars Imperial Star Destroyer.

By his own recollection, fans of opposing teams have called the 6-foot-11 Turner a “child.” They’ve joked that he, an elite shot blocker, would rather be “playing with blocks.” Should one of his field goal attempts clank off the rim, the taunting put-downs about “bricks” write themselves.

“I’ve had to take a lot of heat for it,” Turner said in a phone interview. “It’s never really bothered me because it’s something I’m very secure in, you know?”

Nowadays, hoopers—maybe not Stewart, but plenty of others—do know.

The sport of basketball runs increasingly amok with AFOLs like Turner. Over the past year and change, in college and the pros, athletes looking to spend their downtime a little more productively than, say, pitching coins against a wall are routinely, eagerly turning to Lego as their go-to off-court pursuit.

Victor Wembanyama, the San Antonio Spurs phenom and reigning NBA Rookie of the Year, reportedly treated himself to a Star Wars Millennium Falcon set after signing his first league contract. Milwaukee Bucks captain Giannis Antetokounmpo built Captain America’s shield while recovering from an injury in 2024; his wife documented the occasion on her Instagram Story, writing, “If basketball doesn’t work out, I think you have a bright future building Legos!”

This past off-season, in a 22-second TikTok clip, All-American UConn guard Paige Bueckers and teammate Jana El Alfy showed off nearly 20 Lego sets they’d put together, including a Vespa scooter, the house from Up, and a replica of the Great Pyramid of Giza (which we recommend in our guide to the best Lego sets for adults).

Two photos of basketball players holding different objects they've built out of legos.
Completing a Lego build is just the first part of the process. For hoopers like UConn’s Bueckers and El Alfy, you’ve got to flex your finished builds on TikTok, too. TikTok/paigebueckers

The Dallas Mavericks roster is brimming with Lego enthusiasts. You can find bigs Dereck Lively II, Daniel Gafford, and Anthony Davis all showcasing their builds across social media.

“It’s cool now!” Lively told me in a Zoom interview. (Just two days after we spoke, he auctioned off a “Legos With Lively" shopping spree at a Mavs charity gala for $100,000.) “It’s, like, ‘You’ve gotta try it.’”

Lego has taken notice. After similar collabs with Adidas and Formula 1, the company is planning a partnership with Nike—the sneaker brand synonymous with basketballteasing “a series of co-branded products, content and experiences” that “[reflect our] shared commitment to put creativity, fun, sport and imagination back into play.”

Turner is all for Lego’s expanding popularity in hoops culture: “I wish more people would do it,” he told me. He might, however, bristle at the word choice in that Lego x Nike statement. As he informed the press after a 2023 In-Season Tournament game, “I build Legos. I don’t play with Legos.”

21 Mar 22:18

Career Development: What It Means to Be a Manager, Director, or VP (2015)

by AnhTho_FR
20 Mar 10:29

What Is Cognitive Shuffling?

by Christina Caron
“Cognitive shuffling” can calm a busy brain.
19 Mar 09:44

5 Stunning German Train Trips at a Bargain Price

by Sally McGrane
For less than $65, the Deutschland-Ticket lets you take a month’s worth of unlimited journeys on the country’s regional trains and local transport systems. It’s a low-cost ticket to explore.
06 Mar 22:43

My 16-month theanine self-experiment

by dynomight

The internet loves theanine. This is an amino acid analog that’s naturally found in tea, but now sold as a nutritional supplement for anxiety or mood or memory.

Many people try theanine and report wow or great for ADHD or cured my (social) anxiety or changing my life. And it’s not just the placebo enthusiast community. This hacker news thread is full of positive reports, and gwern uses it regularly.

But does it really work?

Biologically speaking, it’s plausible. Theanine is structurally related to the neurotransmitter glutamate (theanine = C₇H₁₄N₂O₃, glutamate = C₅H₈NO₄-). For some reason, everyone is obsessed with stupid flashy dopamine and serotonin, and no one cares about glutamate. But it’s the most common neurotransmitter and theanine is both metabolized into glutamate and seems to itself have various complicated effects on glutamate receptors.

Of course, there are lots of supplements that could act on the brain, but are useless when taken orally. That’s because your brain is isolated from your circulatory system by a thin layer of cells that are extremely picky about what they let through. But it appears that theanine can get through these cells and into the brain.

So that sounds good. But do these low-level effects actually lead to changes in mood in real humans? When I looked into the academic research, I was surprised by how weak it was. Personally, on these kinds of issues, I find the European Food Safety Authority to be the single most trustworthy scientific body. They did an assessment in 2011 and found:

Claim Result
Improvement of cognitive function cause and effect relationship has not been established
Alleviation of psychological stress cause and effect relationship has not been established
Maintenance of normal sleep cause and effect relationship has not been established
Reduction of menstrual discomfort cause and effect relationship has not been established

Examine is an independent website that’s respected for summarizing the scientific literature on health and supplements. They looked into if theanine helped with various things, like alertness, anxiety, and attention. In all cases found low quality evidence for near zero effect.

A 2020 review of eight randomized double-blind placebo controlled trials found that theanine might help with stress and anxiety. While this review seems generally good, I found it to be insufficiently paranoid. One study they review found that theanine worked better than alprazolam (xanax) for acute anxiety. The correct response would be, “That’s impossible, and the fact that normal scientific practices could lead to such a conclusion casts doubt on everything.” But the review sort of takes it at value and moves on.

After 2020, the only major trial I could find was this 2021 study that took 52 healthy older Japanese people and gave them theanine (or placebo) for 12 weeks. They tested for improvements in a million different measures of cognitive functioning and mostly found nothing.

Why I did this

I’ve long found that tea makes me much less nervous than coffee, even with equal caffeine. Many people have suggested theanine as the explanation, but I’m skeptical. Most tea only has ~5 mg of theanine per cup, while when people supplement, they take 100-400 mg. Apparently grassy shade-grown Japanese teas are particularly high in theanine. And I do find those teas particularly calming. But they still only manage ~25 mg per cup. (Maybe it’s because tea is better than coffee?)

Still, I’ve supplemented theanine on and off for more than 10 years, and it seems helpful. So after seeing the weak scientific evidence, I thought: Why not do a self-experiment?

Theanine seems ideal because it’s a supplement with short term effects. So you can test it against placebo. (Try that with meditation.) And you can build up a large sample using a single human body without waiting weeks for it to build up in the body before each measurement.

Everyone agrees theanine is safe. It’s biologically plausible. While academic studies haven’t proven a benefit, they haven’t disproven one either. Given the vast anecdotal evidence, I saw a chance to stick it to the stodgy scientific establishment, to show the power of internet people and give the first rigorous evidence that theanine really works. Stockholm, prepare thyself.

What I did

First, I needed placebos. This was super annoying. The obvious way to create them would be to buy some empty capsules and fill some with theanine and others with some inert substance. But that doesn’t sound fun. Isn’t the whole idea of modernity that we’re supposed to replace labor with capital?

So I went searching for a pair of capsules I could buy off the shelf, subject to the following constraints:

  1. Capsule A contains 200 mg of theanine.
  2. Capsule B contains something with minimal acute effects on anxiety, stress, memory, concentration, etc.
  3. Capsule B contains something I don’t mind putting into my body.
  4. Both capsules are exactly the same size and weight.
  5. Both capsules are almost but not quite the same color.
  6. Both capsules are made by some company with a history of making at least a modest effort to sell supplements that contain what they say they contain, and that don’t have terrifying levels of heavy metals.
  7. The capsules themselves aren’t made from the skin and bones and connective tissues of dead animals (personal preference).

After a ludicrous amount of searching, I found that NOW® sells these veggie capsules:

Capsule A: 200 mg L-Theanine

Capsule B: 25 mcg (1,000 IU) Vitamin D

These are exactly the same size, exactly the same weight, exactly the same texture, and very close in color. They’re so close in color that under warm lighting, they’re indistinguishable. But under cold/blue lighting, the vitamin D capsules are slightly more yellow. Vitamin D might have some effects on mood, but no one seems to claim that they’re acute, that you’d feel them within an hour.

For dosing, I decided to take a capsule whenever I was feeling stressed or anxious. Some people worry this invalidates the results. Not so! I’m still choosing randomly, and this better reflects how people use theanine in practice.

Theanine is often recommended for reducing anxiety from caffeine. While I didn’t explicitly take caffeine as part of this experiment, I had almost always taken some anyway.

Statistically, it would have been best to randomize so I had a 50% chance of taking theanine and a 50% chance of taking vitamin D. But I decided that would be annoying, since I was taking these capsules when stressed. So I decided to randomize so I got theanine ⅔ of the time and vitamin D ⅓ of the time.

Randomization was very easy: I took two theanine capsules and one vitamin D capsule and put them into a little cup. I then closed my eyes, shook the cup around a bit and took one. I then covered the cup with a card.

capsules

This picture shows one vitamin D capsule (top) and two theanine capsules.

For each trial, I recorded my subjective starting stress level on a scale of 1-5, then set an alarm for an hour, which is enough to reach near-peak concentrations in the blood. After the alarm sounded (or occasionally later, if I missed it) I recorded the end time, my end stress level, and my percentage prediction that what I’d taken was actually theanine. Then, and only then, I looked into the cup. If the two remaining pills were different colors, I’d taken theanine. If not, it was vitamin D.

After ~14 months, I got frustrated by how slowly data was coming in. This was the first time in my life I’ve had too much chill. At that point, I decided to start taking the capsules once or twice a day, even if I wasn’t stressed. I’ll show the transition point in the graphs below.

Ultimately, I collected 94 data points, which look like this:

Date Start time Start stres End time End stress Prediction Result
Nov 18, 2023 9:38 AM 3.5 10:45 AM 2.2 80% T
Nov 19, 2023 9:40 AM 2.8 10:41 AM 2.9 75% T
Feb 28, 2025 4:58 PM 2.1 5:58 PM 1.8 75% D
Mar 3, 2025 6:12 PM 2.1 7:12 PM 2.0 61% T

What are the results?

Bad.

Here are the raw stress levels. Each line line shows one trial, with the start marked with a tiny horizontal bar. Note the clear change when I started dosing daily:

Alternatively, here’s the difference in stress (end - start) as a function of time. If “Δ Stress” is negative, that means stress went down.

Here are the start and end stress levels for each trial, ignoring time. The dotted line shows equal stress levels, so anything below that line means stress went down:

Finally, here are the probabilities I gave that each capsule was in fact theanine.

Thoughts

Ooof.

My stress level did usually go down, at least provided I was stressed at the start. But it went down regardless of if I took theanine or not. And I was terrible at guessing what I’d taken.

Why did my stress decrease when I took vitamin D? Maybe it’s the placebo effect. But I suspect it’s mostly reversion to the mean: If you mark down the times in your life when you’re most stressed, on average you’ll be less stressed an hour later. You can see some evidence for this in that stress tended to decrease more when it started at a higher level.

So, eyeballing the above figures, theanine doesn’t appear to do anything. (We can argue about statistics below.) Why? I think these are the possibilities:

  1. Theanine works, but I got fake theanine.
  2. Theanine works, but vitamin D works equally well.
  3. Theanine works, but I was unlucky.
  4. Theanine works, but I’m disembodied and unable to report my internal states.
  5. Theanine works on some people, but not me.
  6. Theanine doesn’t work.

It’s hard to disprove the idea that theanine works. But I tell you this: I expected it to work. And I really tried. For almost 100 trials over 16 months, I paid attention to what I was feeling and tried to detect any sign that I’d taken theanine, even if it wasn’t a change in stress. I could detect nothing. Even after months of failure, I’d often feel confident that this time I could tell, only to be proven wrong.

So, cards on the table, here are my made-up probabilities for each of the possible explanations:

Explanation belief
Fake theanine 3%
D equally good 1%
Unlucky 6%
Disembodied 15%
Not on me 20%
Doesn’t work 55%

Should I have been surprised by these results? Well, the scientific literature on theanine hasn’t found much of an effect. And the only other good self-experiment on theanine I’ve found is by Niplav, who found it did slightly worse than chance and declared it a “hard pass”.

What about other blinded self-experiments with other substances? They’re surprisingly scarce, but here’s what I could find:

author substance result
Niplav caffeine positive
Gwern amphetamines positive
Gwern lithium no effect
Gwern LSD microdose no effect
Gwern ZMA inconclusive
Slatestarcodex sleep support no effect

Stimulants work! But for everything else…

I particularly encourage you to read the sleep support post. He was confident it worked, he’d recommended it to lots of friends, but it totally failed when put to the test.

I’ve seen many other self-experiments (including for theanine), but they’re non-blinded and I’d be doing you a disservice if I linked to them. People often mention that hypothetically this means the results aren’t scientific, but treat it like a small niggling technicality. It’s not.

So I propose a new rule: Blind trial or GTFO.

I know many people reading this probably use and like theanine. Maybe it works for you! But given the weak academic results, and given the fact that I actually did a blinded experiment, I think you now have the burden of proof. Doing this kind of test isn’t hard. If you’re sure theanine (or anything else) works, prove it.

Appendix: OK fine let’s argue about statistics

Do you demand p-values? Are you outraged I just plotted the data and then started talking about it qualitatively?

I think faith in statistics follows a U-shaped curve. By default, people don’t trust them. If you learn a little statistics, they seem great. (Particularly if you’re part of a community that’s formed a little cult around one set of statistical practices and convinced each other that they’re more reliable than they are.) But if you learn a lot of statistics, then you realize all the assumptions that are needed and all the ways things can go wrong and you become very paranoid.

If you want p-values, I’ll give you p-values. But first let me point out a problem.

While I was blinded during each trial, I saw the theanine/D result when I wrote it down. Over time I couldn’t help but notice that my stress dropped even when I took vitamin D, and that I was terrible at predicting what I’d taken. So while this experiment is randomized and blinded, the data isn’t independent or identically distributed. If I did this again, I’d make sure I couldn’t see any outcomes until the end, perhaps by making 100 numbered envelopes, putting three capsules in each, and only looking at what was left at the end.

But if you want to compute p-values anyway, OK! Here are the basic numbers for the trials when I took theanine:

Variable Substance Mean 95% C.I. p
start stress theanine 2.480 (2.361, 2.599)  
end stress theanine 2.181 (2.104, 2.258)  
Δ stress theanine -0.299 (-0.392, -0.205) 2.00×10⁻⁸
Predicted T theanine 68.4% (66.2%, 70.5%)  

Stress went down, p < .0000001. But here are the the numbers for vitamin D:

Variable Substance Mean 95% C.I. p
start stress vitamin D 2.350 (2.173, 2.526)  
end stress vitamin D 2.025 (1.936, 2.114)  
Δ stress vitamin D -0.325 (-0.453, -0.197) 2.44×10⁻⁵
Predicted T vitamin D 72.9% (69.7%, 76.1%)  

Stress also went down.

Finally, here’s the difference between theanine and vitamin D, computed with a two-sided t-test with unequal variance:

Variable Substance Mean 95% C.I. p
start stress theanine - D 0.130 (-0.095, 0.354) 0.254
end stress theanine - D 0.156 (0.0165, 0.296) 0.029
Δ stress theanine - D -0.026 (-0.201, 0.148) 0.764
Predicted T theanine - D -4.5% (-8.5%, -0.5%) 0.029

Technically, I did find two significant results. But the second row says that end stress was slightly higher with theanine than with vitamin D, and the last row says that I gave slightly higher probabilities that I’d taken theanine when I’d actually taken vitamin D.

Of course, I don’t think this means I’ve proven theanine is harmful. I just think this confirms my general paranoia. To a first approximation, if it ain’t visible in the raw data, I ain’t going.

just look at the data

Speaking of raw data, you can download mine here.

20 Feb 21:23

Scented products cause indoor air pollution on par with car exhaust

by clumsysmurf
11 Feb 19:48

I tasted Honda’s spicy rodent-repelling tape and I will do it again (2021)

by voxadam
10 Feb 23:09

I built an open source AI tool to find my autoimmune disease

by makehistory
09 Feb 06:32

Ethiopia’s Utopian Experiment in Gender Equality

by Peter Yeung

It doesn’t take long to observe that the community of Awra Amba is unlike any other place in Ethiopia — or even the rest of the world.

Here in the breathtaking highlands of northern Ethiopia, not far from the fresh waters of Lake Tana, the largest in the east African nation, an important societal experiment has been underway for the last half century.

Across the lush terrain, women guide oxen to plough the fields. Men sit in their humble adobe homes, sometimes tending to babies or spinning cotton. Here, the gender equality of labor is both the law as well as, seemingly, the genuine reality.

The post Ethiopia’s Utopian Experiment in Gender Equality appeared first on Reasons to be Cheerful.

21 Jan 22:36

I am (not) a failure: Lessons learned from six failed startup attempts

by lisper
16 Jan 17:20

100x defect tolerance: How we solved the yield problem

by jwan584
09 Jan 19:36

Defining Depersonalization Derealization Disorder

by Christina Caron
The sensation of being detached from your surroundings may point to a hard-to-diagnose condition.
07 Jan 22:40

Drug Company to Share Revenues With Indigenous People Who Donated Their Genes

by Brendan Borrell
Variant Bio, a small biotech company based in Seattle, is using genetic information from Indigenous people to develop drugs for obesity and diabetes.
04 Jan 06:49

She Often Fainted in Hot Weather. What Was Wrong?

by Lisa Sanders, M.D.
The woman, a field geologist, was healthy and active, yet she would pass out at inopportune moments.
24 Dec 17:51

My Colleague Julius

by dabacaba
23 Dec 00:01

A Woman With a Rare Gene Mutation Fights to Avoid Her Mother’s Fate

by Virginia Hughes
A mutant gene is coming to steal Linde Jacobs’s mind. Can she find a way to stop it?
22 Dec 00:53

The 10 Architectural Sites You Should See in São Paulo

by Michael Snyder
These buildings and places capture the city’s playful approach to concrete-and-asphalt Modernism.
12 Dec 17:52

Timemap.org – Interactive Map of History

by agilek
02 Dec 22:51

Exploring the Haciendas of Central Mexico

by Freda Moon and Amir Hamja
Within a few hours’ drive of Mexico City, these centuries-old estates have become restaurants, museums, hotels and even water parks. In all of them, beauty and history linger.
02 Dec 07:05

Physical SIM to eSIM Adapters. Any that I missed?

by /u/Martin_Steven

eSIM Adapters let you use eSIMs in phones that only have physical SIM slots.

jmp: https://jmp.chat/esim-adapter . Can be swapped between devices. No limit on the number of profiles. $31.99 plus $5 shipping to U.S.. They sell a USB adapter in case you need to program the eSIM card outside the phone, but a compatibility check can determine whether or not this is necessary. MEP (Multiple Embedded Profiles) status unknown.

5ber: https://esim.5ber.com/order . Can be swapped between devices. $22.50, including shipping (use promo code "5ber") for unlimited eSIM profile downloads. Supports MEP (Multiple Embedded Profiles) on phones that support eUICC (Android 14 or greater). This is the least expensive adapter. There is no option to use an external eSIM programming device.

esim.me: https://esim.me . Various options. Doesn't support MEP (Multiple Embedded Profiles).

9eSIM https://www.9esim.com $31.10 with coupon code "9ber" including shipping and the optional eSIM programming device in case your phone can't write directly to the eSIM adapter. MEP (Multiple Embedded Profiles) status unknown.

In some cases you can have two active eSIM profiles at the same time, while using a single eSIM adapter: "For devices running Android 13 or higher, Android supports multiple enabled profiles (MEPs) for eUICC. This feature allows devices to have dual SIM support using a single eSIM chip, which can have multiple SIM profiles and can connect to two different carriers at the same time."

There is an upside to this in that you could have a U.S. eSIM active and use "Wi-Fi" calling using data from a data-only travel eSIM. However of course you can't have a U.S. eSIM and purchase a region-specific or country-specific foreign physical SIM, which is what many travelers like to do in order to minimize the cost of foreign data. A data-only travel eSIM is likely to cost at least $2/GB of data.

https://medium.com/@brandfluxgroup/esim-hacks-getting-esims-to-work-on-any-device-euicc-on-a-chip-9e794ef190b5

submitted by /u/Martin_Steven to r/NoContract
[link] [comments]
26 Nov 19:16

Modern Warfare Is Breeding Deadly Superbugs. Why?

by Francesca Mari
Researchers are trying to understand why resistant pathogens are so prevalent in the war-torn nations of the Middle East.