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09 Dec 18:41

The search for a blockbuster insomnia drug

by Jason Kottke

Merck is working on a new insomnia drug that they claim has few of the sometimes nasty side effects of other drugs like Ambien. Ian Parker reports for the New Yorker.

If the Merck scientists succeeded at the F.D.A., they would be the first to bring an orexin-related drug to market. "It's an amazing achievement," Richard Hargreaves, the fourth colleague at the Hilton, said. "Everyone should be really proud." But, he added, "my worry is that a new mechanism is being evaluated on the science of an old mechanism."

"With Ambien, you've got a drug that's got basically only onset," Renger said, dismissively. That is, it sends you to sleep but might not keep you asleep. "Suvorexant has the onset, but it has the great maintenance, especially in the last third of the night, where other drugs fail." And even though suvorexant keeps working longer than Ambien, suvorexant patients don't feel groggier afterward, as you might expect. Impassioned, Renger imagined himself addressing the F.D.A.: "Why aren't you giving this a chance?"

"Drugs usually have some side effects," Schoepp said. "It's all benefit-risk." He added, "There is some dose where suvorexant will be ultimately safe-because nothing will happen. If you go low enough, it becomes homeopathic."

They stood to go to their rooms. Schoepp murmured, "I'd love to take it right now."

Tags: drugs   Ian Parker   medicine   Merck
04 Dec 04:50

St. Mark's Place 7-Eleven Has CLOSED

by Rebecca Fishbein
St. Mark's Place 7-Eleven Has CLOSED AHA. Though 7-Eleven has made every attempt to stick its Slurpee-ed fingers into Manhattan's beloved bodega scene, at least one outpost has lost its fight for homogeneity. The St. Mark's Place outpost is no more. 1 down, 10,199 to go! [ more › ]
    






03 Dec 21:49

Bundler to be integrated into Rubygems

03 Dec 21:17

Chicago Sun-Times could rehire photographers after replacing them with iPhones

by Jacob Kastrenakes

Four of the Chicago Sun-Times photographers who were fired earlier this year could be hired back as part of a newspaper union's agreement with the paper's owner, Sun-Times Media. The Sun-Times faced considerable criticism over the summer after laying off all 28 of its staff photographers — including one Pulitzer Prize winner — and implying that they could be replaced by freelancers and reporters trained to shoot photos and videos with iPhones. Though only four photographers would be returning as part of the agreement between Sun-Times Media and the Chicago Newspaper Guild, the deal would also give all guild members added job security and more pay. So far two of the Guild's five units have ratified the new agreement, and the...

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03 Dec 17:00

New Malware Can Jump Air Gaps Using Inaudible Sound

by Jamie Condliffe

New Malware Can Jump Air Gaps Using Inaudible Sound

A team of computer scientists has developed a new breed of malware, which can leap between devices using inaudible audio signals—then covertly transmit passwords and other sensitive data without a network connection.

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03 Dec 16:54

Painting Morgan Freeman

by Jason Kottke

Morgan Freeman Painting

Using an iPad app called Procreate, artist Kyle Lambert made this painting of Morgan Freeman. It took him 200 hours. The video of him doing it is mesmerizing:

(via gizmodo)

Tags: art   iPad apps   Kyle Lambert   Morgan Freeman   video
03 Dec 15:35

Oracle and Oregon’s Online Health Care Exchange

by John Gruber

Steve Henn, reporting for NPR:

Oregon has spent more than $40 million to build its own online health care exchange. It gave that money to a Silicon Valley titan, Oracle, but the result has been a disaster of missed deadlines, a nonworking website and a state forced to process thousands of insurance applications on paper. […]

Initially, Oracle promised it could get the job done. But by mid-May, the head of Cover Oregon, Rocky King, had written the company, pleading for “a simple calendar schedule … to ascertain whether or not we will be able to deliver” a working exchange by Oct. 1.

Five months later, when Oregon’s exchange was supposed to go live, the site still didn’t work. And as recently as two weeks ago, the state had not yet managed to sign up a single person for private health insurance under the federal Affordable Care Act.

03 Dec 15:17

"I'm proud to announce that more than 2.1 million PS4s have been sold."

by András Neltz

"I'm proud to announce that more than 2.1 million PS4s have been sold." Sony Computer Entertainment head honcho Andrew House, in a blog post thanking fans for their commitment and promising that "Playstation [will remain] the best place to play."

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03 Dec 01:20

Simplifiers and Optimizers, by Dilbert creator Scott Adams

by Scott Adams

Some people are what I call simplifiers and some are optimizers. A simplifier will prefer the easy way to accomplish a task, while knowing that some amount of extra effort might have produced a better outcome. An optimizer looks for the very best solution even if the extra complexity increases the odds of unexpected problems. I have a bias for simplification, but surely there are situations in which optimizing is the better play. So how do you know which approach works best in a given situation?

If the situation involves communication with others, simplification is almost always the right answer. If the task is something you can do all by yourself, or with a partner who is on your wavelength, optimizing might be a better path if you can control most variables in the situation. And realistically, sometimes you simply have to get three hours of tasks completed in two hours, so we don’t always have the luxury of being able to choose simple paths.

I prefer simplicity whenever I’m choosing a system to use. People can follow simple systems better than complicated ones. I’ll give you some examples of that in later chapters about fitness and diet. The most optimized diet plan or fitness plan will also be the most complicated. But few people have enough willpower in reserve to follow complicated plans.

If you can’t tell whether a simple plan or a complicated one will be the best, choose the simple one. If it’s a coin toss, you might as well do whatever is easiest.

If the cost of failure is high, simple tasks are the best because they are easier to manage and control. Missing a dinner reservation isn’t the end of the world, so doing some optimizing in that case is defensible. But if you are driving to an important business meeting, you don’t want to pile on some errands that are “on the way,” because that introduces unwanted stress and uncertainty.

In my career I’ve always felt that my knack for simplicity was a sort of superpower. For example, when I draw Dilbert I include little or no background art in most panels, and when I do, it’s usually simple. That’s a gigantic time-saver.

I assume that other cartoonists retire early at least in part because they are optimizers, and that level of energy can be hard to sustain in the long run. No one reads Dilbert comics for the artwork. I have the luxury of being able to do simple drawings directly on the computer using a Wacom Cintiq device (a computer screen on which you can draw). I type the dialogue using a special font I created of my handwriting. Over the years I have streamlined the system to the point where I can bang out a comic in about an hour if I need to, although I usually take longer. Dilbert was designed from the start to be simple to create, and I continue to streamline the process. That simplicity has paid off big-time because it frees me to blog, write books, do interesting side projects, and still enjoy life.

Optimizing is often the strategy of people who have specific goals and feel the need to do everything in their power to achieve them. Simplifying is generally the strategy of people who view the world in terms of systems. The best systems are simple, and for good reason. Complicated systems have more opportunities for failure. Human nature is such that we’re good at following simple systems and not so good at following complicated systems.

Excerpt adapted from How to Fail at Almost Everything and Still Win Big: Kind of the Story of My Life by Scott Adams, in agreement with Portfolio, an imprint of Penguin Random House. Copyright (c) Scott Adams, 2013.

Simple systems are probably the best way to achieve success. Once you have success, optimizing begins to have more value. Successful people and successful businesses have the luxury of being able to op- timize toward perfection over time. Start-ups often do better by slapping together something that is 80 percent good and seeing how the public responds. There’s time to improve things later if the market cares about the product.

Another big advantage of simplification is that it frees up time, and time is one of your most valuable resources in the world. If you give an ant infinite time, he can move a mountain all by himself. In my case, I can run the equivalent of three separate careers (cartoonist, author, entrepreneur) in the same forty-hour week that would normally accommodate one job.

Simplification frees up energy, making everything else you do just a little bit easier. That’s a huge deal. You don’t want your job interview to go poorly because on the way to the interview you completed four complicated errands that turned you into a ball of stress. When you are trying to decide between optimizing and simplifying, think of your entire day, not the handful of tasks in question. In other words, maximize your personal energy, not the number of tasks. As I mentioned earlier, we don’t always have the option of choosing simplicity, especially if we have a thousand things to complete in a day. But it’s a good idea to have an overarching plan to move toward simple systems as opportunities allow. You can chip away at the complexity of your life over time. Simplicity is a worthy long-term goal. That’s how you will free your personal energy so you can concentrate it where you need it.

[Listen to Mark's interview with Scott Adams about his book, How to Fail at Almost Everything and Still Win Big: Kind of the Story of My Life.]

    






02 Dec 23:03

Canon EOS 6D 20.2MP Full Frame DSLR Camera + 24-105mm f/4L Lens + 2% Rewards + Goodies $2084 + Free Shipping

02 Dec 22:35

Apple buys Topsy, a Twitter search and analytics firm

by Jacob Kastrenakes

Apple has purchased Topsy, a search engine and analytics firm for tweets that's been one of Twitter's biggest partners, reports The Wall Street Journal. Though there's no clear implication for what Apple might do with Topsy, the Journal suggests that it could begin using Topsy's data to better target ads, to inform users of its products about popular subjects, or to generally tap into of-the-moment interests. Apple confirmed the acquisition to the Journal, which reports that the purchase price was over $200 million.

Continue reading…

02 Dec 22:06

Cronut Mania: Dominique Ansel has introduced a "Winter...

by Marguerite Preston

cronutlineblackfriday.jpgDominique Ansel has introduced a "Winter Pass" system to the Cronut line to try to cut down the amount of time that the patient masses have to spend waiting in the cold. At 7 a.m. and 8 a.m. every day he'll hand out a limited number of tickets that will allow the recipients to come back and collect their Cronuts between 9 and 10 a.m. or 10 and 11 a.m. respectively. [Facebook]

02 Dec 22:04

Meals on Wheels: Washington Square Park Is Banishing its Hot Dog Carts

by Marguerite Preston

washsquarepark.jpgA newly-formed Washington Square Park Conservancy group has successfully lobbied the Parks Department to kick out all of the hot dog vendors. The Post reports that the Conservancy first convinced officials to nudge the hot dog carts to the outer edges of the park back in March, on the grounds that they were "unsightly." Now the park has allowed these vendors' contracts to expire, and all of the resident hot dog carts will be gone by the end of the month.

Otto's gelato cart and the well-loved NY Dosas cart, on the other hand, have been allowed to stick around, and the park has also signed a deal with Melt for an ice cream sandwich cart. All this, a spokesperson tells the Post, is in order to "ensure clear views of the fountain and arch and...to bring in a more diverse selection of food options." But for the hot dog vendors, it just means making "hundreds less [a week]" in profits.
· Washington Square Park Banning Hot Dog Vendors [NYP]
· All Coverage of Food Trucks [~ENY~]

02 Dec 17:24

Coming Attractions: The Seaport is Getting a Giant, Eataly-Style Food Market

by Marguerite Preston

seaport%20development.jpgThe Howard Hughes Corporation, which now owns much of the property at the South Street Seaport, reportedly has plans to build a new 40,000 square-foot Eataly-esque food market in the neighborhood. According to the Post, the corporation has approached a handful of yet-unnamed celebrity chefs to curate the market, so that unlike Eataly's singular Italian focus, this would be a "globally diverse marketplace."

No word yet on where the new market will be, but this is likely part of the deal the corporation reached with the City Council earlier this year, which requires that it include two regionally-sourced food markets in its development plans. As of now those plans also include replacing Pier 17 mall with a bigger, fancier one, and a proposed 50-story tower in place of the historic New Market Building, once a part of the old Fulton Fish Market.
· New Food Market Coming to South Street Seaport [NYP]
· All Coverage of South Street Seaport [~ENY~]

02 Dec 05:26

Amazon's Cyber Monday Gaming Deals Are Live At 3:01am ET [Corrected]

by Shane Roberts, Commerce Team

Amazon's Cyber Monday Gaming Deals Are Live At 3:01am ET [Corrected]

Update: Multiple publications, myself among them, were confused about the format of these gaming deals. These are not lightning deals, and should run all day on Dec. 2, unless of course stock runs out.

Read more...

02 Dec 02:37

Paul Walker, 40, ‘Fast & Furious’ Star, Dies in Car Crash

by By THE ASSOCIATED PRESS
Mr. Walker, the star of the “Fast & Furious” movie series, died Saturday in a car crash that killed two people north of Los Angeles, his publicist said.
    






30 Nov 08:58

Google Fonts: more than a trillion served

29 Nov 22:33

Even the Crappiest of Computers Can Handle ASCII Fluid Simulations

by Andrew Liszewski

Even the Crappiest of Computers Can Handle ASCII Fluid Simulations

The incredibly lifelike computer simulations of snow and water seen in effects-heavy Hollywood blockbusters—and even video games—require a significant amount of computing power. It's not uncommon for a single frame of a movie to require days to render, and these days visual effect studios have more computing power than Nasa. But Yusuke Endoh has created a slightly cruder text-based fluid simulation that requires far less hardware.

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29 Nov 22:27

For 20 Years the Nuclear Launch Code at US Minuteman Silos Was 00000000

by Karl Smallwood - TodayIFoundOut.com

For 20 Years the Nuclear Launch Code at US Minuteman Silos Was 00000000Today I found out that during the height of the Cold War, the US military put such an emphasis on a rapid response to an attack on American soil, that to minimize any foreseeable delay in launching a nuclear missile, for nearly two decades they intentionally set the launch codes at every silo in the US to 8 zeroes.

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29 Nov 22:26

This Rolls-Royce Tanker Is a School Bus for Salmon

by Andrew Tarantola

This Rolls-Royce Tanker Is a School Bus for Salmon

Fish tends to spoil fast, even when kept on ice. So to ensure that farm-raised salmon remain at peak of their freshness (read: still swimming) for whole trip to back to shore for processing, Rolls-Royce is building the world's largest mobile aquarium/meat wagon.

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29 Nov 07:42

China, and the Soaring Price of Bitcoin

by John Gruber

Tyler Cowen, writing at Marginal Revolution:

Right now, you can think of the value of Bitcoin being set in the same way that the value of an export license might be set through bids. If/when China fully liberalizes capital flows, the value of Bitcoin likely will fall. A lot. To the extent the shadow market value of the yuan rises, and approaches the level of the current quasi-peg, the value of Bitcoin will fall, by how much is not clear. Or maybe getting money out through Hong Kong (or Shanghai) will become easier and again the value of Bitcoin would fall. If Beijing shuts down BTC China, the main broker, which by the way accounts for about 1/3 of all Bitcoin transactions in the world, the value of Bitcoin very likely will fall. A lot. You will recall that the Chinese government shut down the virtual currency QQ in 2009; admittedly stopping Bitcoin could prove harder but still they could thwart or limit it.

(Via Scott Simpson.)

28 Nov 17:57

The Worst Thing About Being A VC Is Other VCs

by Ryan Lawler

So you think you want to be a VC. It sounds like a pretty cool job, after all. You have good pay and benefits, get to meet with lots of interesting entrepreneurs, play with cool technology, can hang out in khakis all day…

But what about the dark side of venture capital? What's the worst part about having an office on Sand Hill Road and investing other people's money? (Hint: It's not eating breakfast at Madera, getting coffee at The Creamery, or having drinks at the Four Seasons Battery every day.)

A thread on Quora seeks to find an answer to just this topic, and it's one of the more interesting reads you might run across on the QA site. While there are lots of great answers from folks like Mark Suster, Ethan Kurzweil, and Andrew Parker,* the runaway favorite is a response from an anonymous VC who claims 10 years of experience as a general partner at one of the bigger venture funds out there.

While noting that being a VC “is really the greatest job on earth” and that “saying no” wasn't a hard part of the job, just part of the job, Anonymous goes on to describe the things that really do suck about being a VC… Which can pretty much be boiled down to “dealing with other VCs.”

That includes both VCs within your own firm, as well as those you co-invest with. Let's start with those you work with directly:

At a large fund, there are lots of partners. And what it takes to become a partner at a big fund and stay there for years is often a high asshole factor, ability and desire to deal with firm politics and internal jockeying for power.

Don't get me wrong. There are some great great partners. But I think 2/3rds of the people in the GP ranks at big firms have massive egos (as one LP put it “VCs have more ego per dollar of return than any asset class we know of”)

Not surprisingly, Anonymous goes on to break out the “crazy back room politics” general partners deal with, as well as senior partners who don't add a lot of value and JUST. WON'T. RETIRE.

So maybe you're able to navigate the assholes you choose to work with. What about those you end up on boards with? Anonymous paints an even bleaker picture there: When it comes to companies that have multiple VCs as board members, each has “their own agendas and egos”… And, big surprise, those agendas aren't always focused on what's best for the company, but external stuff like “fund reserves, fund life, etc.” which impact their decisions and advice.

If you can get through all of that, then you're faced with dealing with the clueless limited partners who invest in your fund. As Anonymous describes, “LPs are the lagging-most indicators in the entire economy.” And, well, don't really understand (or care to) what they're actually investing in.

Anonymous also describes all the loneliness associated with being a VC, as well as the emotional ups and downs that they go through when portfolio companies aren't really working out the way they'd hoped. But let's face it, it's tough to feel sorry for anyone making “$500k to $2M per year” whose job it is to pick winners and losers in the game of tech.

Anyway, now here's the fun part: We know enough about Anonymous to make a reasonable guess as to who he or she is, or at least which firm he or she works for. Being a general partner for 10 years at a “big fund” with “multiple tiers of partners,” “crazy back room politics” and “senior partners who are well past medicare age” kind of narrows things down a little. (Or, well, maybe not.) Anyone care to take a guess which firm we're talking about?

==
* My favorite response actually comes from Kristine Lauria, who is married to a VC and says the worst part of being one is “High risk of divorce because you never see your wife.” OOOOH BURN.


28 Nov 03:09

This animated Donkey Kong wedding cake just won best nerd cake forever

by Jesus Diaz on Sploid, shared by Jesus Diaz to Gizmodo

This animated Donkey Kong wedding cake just won best nerd cake forever

It's going to be impossible to beat the glorious nerdness level in this wedding cake, which uses projectors to animate Mario on his quest to beat Donkey Kong and rescue Pauline. Unless they find a way to modify the sugar molecules to act as color displays.

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28 Nov 00:23

Redesigned Google Maps can now be embedded in websites

by Jacob Kastrenakes

The new Google Maps is about to start popping up around the web: Google has finally added in the option for users to embed maps featuring the overhauled design that it debuted back in May. While the new Google Maps worked just fine for searching and browsing when it was first launched in beta, it was missing a number of features and easy shortcuts that have since been added in. Embedded maps wouldn't have made much sense at first — the redesign was released in a closed beta after all — but it's since been opened up to anyone interested in using it, and allowing embedded maps now could be a move by Google to get even more people used to the changes.

Continue reading…

27 Nov 22:48

Louis Vuitton Comes to Red Square, and Moscow Is Not Pleased

by By ANDREW ROTH
The designer has built a temporary, two-story replica of a traveling trunk, but to some officials, it is not temporary enough.
    






27 Nov 21:11

Report: Angry Birds Go! has $100 microtransaction in soft launch

by Jessica Conditt
Rovio's kart racing game, Angry Birds Go!, is heavy on microtransactions - including one in-game car that sells for $100, Pocket Gamer reports. The game is out in a soft launch in New Zealand, though it doesn't hit worldwide until December 11.

Angry Birds Go! is free-to-play with a classic mix of in-game currency: gems and coins. Players grab coins in races and use them to upgrade a kart's specs. Upgrading a kart increases your CC ratings, and the higher CC rating, the more tracks you can play. Gems are the premium currency, used to get more coins. Players can also buy gems with real money.

The standard cars can only be upgraded so far and the better cars cost real money, the site reports. The Big Bang Special Edition car costs $100 (though a picture on Pocket Gamer shows it costs $125). Buying the game's related real-life Hasbro toys, Telepods, can also unlock cars and game modes.

This is all based on the soft launch of Angry Birds Go!, so prices and processes are subject to change.

JoystiqReport: Angry Birds Go! has $100 microtransaction in soft launch originally appeared on Joystiq on Wed, 27 Nov 2013 15:30:00 EST. Please see our terms for use of feeds.

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27 Nov 19:06

Steam Autumn Sale day 1: Walking Dead, Rogue Legacy, Outlast

by Jessica Conditt
The Steam Autumn Sale is here, just in time for this week's Black Friday - it runs from November 27 to December 3, with Daily Deals and Flash Sales aplenty. Today, Daily Deals include The Walking Dead for $6.25, Outlast for $6.80, Terraria for $2.50, and Antichamber, Rogue Legacy, Left 4 Dead 2 and Sleeping Dogs for $5. Also, Skyrim for $7.50 and Prison Architect for $15.

Flash Sales refresh every eight hours, but the first batch has Crysis 2 Maximum Edition for $7.50, Space Hulk for $10, HammerWatch for $3.40 and Castle Story for $13.40.

Be sure to check out the sales on indie games, too.

JoystiqSteam Autumn Sale day 1: Walking Dead, Rogue Legacy, Outlast originally appeared on Joystiq on Wed, 27 Nov 2013 13:20:00 EST. Please see our terms for use of feeds.

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27 Nov 17:06

World Cup stadium in Sao Paulo, Brazil breaks apart, killing three

by Adi Robertson

Part of the Arena Corinthians, future site of the World Cup opening ceremony in June 2014, has collapsed, reportedly killing three. The stadium, located in Sao Paulo, Brazil, was still under construction with a set completion date of December, and the BBC reports that a crane collapsed onto the structure, breaking off part of the stands as seen in this photograph from the Futebolnopronto Twitter account. More photographs show the crane dangling over the edge of the stands and what may be fire trucks that were called to the scene after the collapse; emergency crews are still checking for more possible victims.

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27 Nov 17:05

American Airlines and US Airways will merge to form world's largest airline on December 9th

by Chris Welch

American Airlines and US Airways will combine early next month and create the world's largest airline. A New York judge today approved the settlement reached earlier this month between the Justice Department and both airlines, allowing American to emerge from bankruptcy to complete the merger. AMR Corporation, parent of American Airlines, says the deal will be finalized on December 9th. The DOJ had initially (and aggressively) tried to prevent the two popular US airlines from becoming one, arguing that the move would hike airfare for all travelers and harm competition within the industry.

But as the antitrust battle waged on, the Justice Department grew less combative, agreeing to allow the merger if American and US Airways would give...

Continue reading…

27 Nov 15:54

Sriracha Factory Ordered to Cease Unneighborly Operations by California Judge

by Hugh Merwin

Endangered hot sauce.

Last night, a Los Angeles Superior Court judge ruled that David Tran's Huy Fong Foods factory must cease any kind of production that causes the strong odors wafting through the neighborhood and ruining people's lives. The Irwindale, California, complex produces the entire world's supply of Tran's beloved brand of Sriracha sauce. In the ruling, Judge Robert H O'Brien wrote that the pesky burning sensation neighbors have been complaining about can be "reasonably inferred to be emanating from the facility." Interestingly enough, Huy Fong isn't now required to stop all operations, just those that are nebulously defined to be causing a public nuisance. The judge is expected to sign the injunction this morning, so don't be surprised if you read about a human-chain barricade consisting of people in red-and-green hot sauce costumes blocking the courthouse a little later today. [LA Times, Earlier, Earlier]

Read more posts by Hugh Merwin

Filed Under: david tran, feel the burn, hot sauce, huy fong, sriracha