Enantioselective dearomative prenylation of indole derivatives
Enantioselective dearomative prenylation of indole derivatives, Published online: 06 August 2018; doi:10.1038/s41929-018-0111-8
Prenylation is a common step in the synthesis of many natural products, and enantioselective variants require the use of enzymatic catalysts. Now, You and co-workers report a palladium phosphoramidite catalyst capable of enantioselective, dearomative prenylations across a broad range of starting materials, and demonstrate its power in a number of natural product syntheses.