Publication date: 1 June 2022
Source: Nano Energy, Volume 96
Author(s): Wook Kim, Joon Hui Park, Hee Jae Hwang, You Seung Rim, Dukhyun Choi
Publication date: 1 June 2022
Source: Nano Energy, Volume 96
Author(s): Wook Kim, Joon Hui Park, Hee Jae Hwang, You Seung Rim, Dukhyun Choi
The ongoing unprecedented severe acute respiratory syndrome caused by the SARS-CoV-2 outbreak worldwide has highlighted the need for understanding viral-host interactions involved in mechanisms of virulence. Here, we show that the virulence factor Nsp1 protein of SARS-CoV-2 interacts with the host messenger RNA (mRNA) export receptor heterodimer NXF1-NXT1, which is responsible for nuclear export of cellular mRNAs. Nsp1 prevents proper binding of NXF1 to mRNA export adaptors and NXF1 docking at the nuclear pore complex. As a result, a significant number of cellular mRNAs are retained in the nucleus during infection. Increased levels of NXF1 rescues the Nsp1-mediated mRNA export block and inhibits SARS-CoV-2 infection. Thus, antagonizing the Nsp1 inhibitory function on mRNA export may represent a strategy to restoring proper antiviral host gene expression in infected cells.
Nature Physics, Published online: 12 August 2019; doi:10.1038/s41567-019-0618-1
An observation that cells at the edge of a healing wound readily undergo intercalation leads to the finding that tissue fluidity is crucial for effective wound closure.A highly flexible Fe1− x S@PCNWs/rGO hybrid paper electrode with robust mechanical properties is successfully fabricated and shown to exhibit superior sodium storage properties with high volumetric and gravimetric capacities. Using this paper anode, a flexible sodium ion battery is also fabricated and shown to exhibit promising performance.
Smart construction of ultraflexible electrodes with superior gravimetric and volumetric capacities is still challenging yet significant for sodium ion batteries (SIBs) toward wearable electronic devices. Herein, a hybrid film made of hierarchical Fe1− x S‐filled porous carbon nanowires/reduced graphene oxide (Fe1− x S@PCNWs/rGO) is synthesized through a facile assembly and sulfuration strategy. The resultant hybrid paper exhibits high flexibility and structural stability. The multidimensional paper architecture possesses several advantages, including rendering an efficient electron/ion transport network, buffering the volume expansion of Fe1− x S nanoparticles, mitigating the dissolution of polysulfides, and enabling superior kinetics toward efficient sodium storage. When evaluated as a self‐supporting anode for SIBs, the Fe1− x S@PCNWs/rGO paper electrode exhibits remarkable reversible capacities of 573–89 mAh g−1 over 100 consecutive cycles at 0.1 A g−1 with areal mass loadings of 0.9–11.2 mg cm−2 and high volumetric capacities of 424–180 mAh cm−3 in the current density range of 0.2–5 A g−1. More competitively, a SIB based on this flexible Fe1− x S@PCNWs/rGO anode demonstrates outstanding electrochemical properties, thus highlighting its enormous potential in versatile flexible and wearable applications.
The integration of a high‐temperature degradable poly‐α‐methylstyrene interlayer enables a distinct and irreversible degradation process for flexible single crystal silicon nanomembrane devices at 300 °C. Systematic experiments and simulations reveal the failure mechanism. This work provides a foundation for understanding the transient mode of future on‐chip components in high‐temperature electronics.
An advanced transient approach enables the sudden degradation and subsequent disappearance of device‐grade electronic systems on a temporary platform with limited remains over a desired period for long‐term stable operation. To satisfy the requirements for flexible devices in transient electronics capable of working at high temperature, transient Si‐nanomembrane (Si‐NM) electronics integrated with high‐temperature degradable poly‐α‐methylstyrene (PAMS) are presented. Systematic experimental studies suggest that a 4 µm thick PAMS interlayer in the Si‐NM device ensures stable operation below the decomposition temperature of PAMS (≈300 °C), while the device undergoes transient process when triggered at higher temperature. Experimental characterization and theoretical modeling reveal the essential properties of the flexible device and its failure mechanism. Demonstrations of such a transient component in high‐temperature electronics highlight the potential advantages in the demands for circuit safeguards, information security, and sensing/control systems.
On page 9979, a novel carbon coated porous Al foil as the anode and current collector for the dual-ion battery (DIB) is reported by Yongbing Tang and co-workers, which exhibits longterm cycling stability of over 1000 cycles with 89.4% retention at 2C. The energy density of this DIB is about 204 Wh kg−1 at a high power density of 3084 W kg−1, which is two times as large as most commercial lithium ion batteries.
The first asymmetric [3+1]-cycloaddition was successfully achieved by copper(I) triflate/double-sidearmed bisoxazoline complex catalyzed reactions of β-triisopropylsilyl-substituted enoldiazo compounds with sulfur ylides. This methodology delivered a series of chiral cyclobutenes in good yields with high enantio- and diastereoselectivities (up to 99 % ee, and >20:1 d.r.). Additionally, the [3+1]-cycloaddition of catalytically generated metallo-enolcarbenes was successfully extended to reaction with a stable benzylidene dichlororuthenium complex.
Three plus one: β-Triisopropylsilyl-substituted enoldiazo compounds react with sulfur ylides in a [3+1]-cycloaddition reaction catalyzed by copper(I) triflate/double-sidearmed bisoxazoline complex (see figure) to give cyclobutenes. The asymmetric version proceeds in good yield with high enantio- and diastereoselectivity.
Article
Stationary radiative shocks are expected to form above the surface of highly-magnetized white dwarves in binary systems, but this cannot be resolved by telescopes. Here, the authors report a laboratory experiment showing the evolution of a reverse shock when both ionization and radiative losses are important.
Nature Communications doi: 10.1038/ncomms11899
Authors: J. E. Cross, G. Gregori, J. M. Foster, P. Graham, J. -M. Bonnet-Bidaud, C. Busschaert, N. Charpentier, C. N. Danson, H. W. Doyle, R. P. Drake, J. Fyrth, E. T. Gumbrell, M. Koenig, C. Krauland, C. C. Kuranz, B. Loupias, C. Michaut, M. Mouchet, S. Patankar, J. Skidmore, C. Spindloe, E. R. Tubman, N. Woolsey, R. Yurchak, É. Falize
Article
Glucocorticoids are widely used as coadjuvants in the treatment of solid tumours. Here, Chen et al . show that genes regulated by dexamethasone- but not Compound A-liganded glucocorticoid receptor are associated with therapy resistance and unfavourable clinical outcomes in triple-negative breast cancer.
Nature Communications doi: 10.1038/ncomms9323
Authors: Zhong Chen, Xun Lan, Dayong Wu, Benjamin Sunkel, Zhenqing Ye, Jiaoti Huang, Zhihua Liu, Steven K. Clinton, Victor X. Jin, Qianben Wang
Transition metal sulfides have a great potential for energy storage due to the pronouncedly higher capacity (owing to conversion to metal or even alloy) than traditional insertion electrode materials. However, the poor cycling stability still limits the development and application in lithium and sodium ion batteries. Here, taking SnS as a model material, a novel general strategy is proposed to fabricate a 3D porous interconnected metal sulfide/carbon nanocomposite by the electrostatic spray deposition technique without adding any expensive carbonaceous materials such as graphene or carbon nanotube. In this way, small nanorods of SnS are generated with sizes of ≈10–20 nm embedded in amorphous carbon and self-assembled into a 3D porous interconnected nanocomposite. The SnS:C is directly deposited on the Ti foil as a current collector and neither conductive additives nor binder are needed for battery assembly. Such electrodes exhibit a high reversible capacity, high rate capability, and long cycling stability for both lithium and sodium storage.
A novel general strategy for fabrication of a 3D porous interconnected metal sulfide/carbon nanocomposite is proposed, using the electrostatic spray deposition technique without adding any expensive carbonaceous materials such as graphene or carbon nanotubes. Such SnS/C composite exhibits a high reversible capacity, high rate capability and long cycling stability for both lithium and sodium storage.
The entrapment of free-lithium in a 3D fibrous Li7B6 framework produces a LiB nanostructured anode with a stable interface. This structure is demonstrated by Q. Zhang and co-workers on page 4257. The nanostructured anode not only reduces the areal current density that lowers the growth velocity of lithium deposits, but also limits the final size of the deposited lithium, which leads to a dendrite-free morphology at the macroscale.